Wound healing activity of methanolic extract of the leaves of Crataeva magna and Euphorbia nerifolia in rats

Abstract

Crataeva magna and Euphorbia nerifolia have been shown to possess hepatoprotective activity and antioxidant property. The present works with these plants were undertaken with the premise that the drug promoting hepatoprotective activity and radical scavenging property could have effect on wound healing also. The wound healing property of the methanolic extract of the leaves of Crataeva magna (CNM) and Euphorbia nerifolia (ENM) were chosen to investigate in excision and incision wound models. The methanolic extracts of the two plants at the dose of 500 mg/kg/day by topically applying method. Healing was assessed by the rate of wound contraction, time until complete epithelialization, incision breaking strength, estimation of hydroxyproline and histopathological parameters. Complete wound contraction was shown by both the plants in the study period. In excision and incision wound models, all the test drugs showed significant (P<0.001) wound healing activities compared to the control. Moreover the CNM was found to possess significant wound healing activities than the ENM and had been observed to have equipotent wound healing activity as of the standard drug Framycetin.

Studies on Wound Healing Activity of Some Euphorbia Species on Experimental Rats

“…The results obtained are similar to the wound healing potential of latex of Euphorbia caducifolia which showed an acceleration of wound closure with higher fibroblasts and collagen content in treated animals (Goyal et al, 2012). Same type of wound healing effect is also observed in Euphorbia nerifolia (Pattanaik et al, 2014).…”

“…Some species of the genus Euphorbia are used in folkloric medicines to cure skin disorders, gonorrhea, intestinal parasites, migraine and wart (Singla and Pathak, 1990). Few Euphorbia species have also been reported for wound healing potential (Goyal et al, 2012;Pattanaik et al, 2014;Bigoniya et al, 2013).…”