Topical application of stem bark ethanol extract of Sonapatha, Oroxylum indicum (L.) Kurz accelerates healing of deep dermal excision wound in Swiss albino mice

Lalrinzuali, Khawlhring; Vabeiryureilai, Mathipi; Jagetia, Ganesh Chandra

doi:10.1016/j.jep.2018.08.018

Cited by 18 publications

(12 citation statements)

References 45 publications

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“…Phase two counted for two to up to six hours and larger edema formation occur characterized by redness and swelling. This inflammatory action was due to various inflammatory chemicals like prostaglandin, prostacyclin, and leukotriene followed by the pathway COX 2 mechanism [22,[70][71][72][73]. Noticeably Figure 1(a) group was distilled water treated paw with no carrageenan injection which demonstrated damaged tissue and was conserved for the identification of dermal collagen and leukocytes.…”

Section: Discussionmentioning

confidence: 99%

“…For bark or stem bark, many biochemical activities have been assessed like antimicrobial, antidiarrheal, analgesic, cytotoxic, hepatoprotective, gastroprotective, antiproliferative, antimetastatic, antiobesity potential, and antioxidant activities [20][21][22][23][24][25][26][27][28][29][30][31] and seed has antidiabetic potentials and showed synergistic potentials with acarbose [32]. Various flavonoids, namely, 5,7-dihydroxyflavone, 5,7-dihydroxy-3methoxyflavone, 3,5,7-trihydroxyflavone, 5,7,4 -trihydroxy-3-methoxyflavone, 3,5,7,4 -tetrahydroxy flavone, and 5,7,4trihydroxyflavone, were identified and separated from the stem bark portion of O. indicum and structure of isolated chemicals was characterized [33][34][35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacological Inspections of Organic Extract ofOroxylum indicumin Rat Models: A Promising Natural Gift

Begum

Islam

Begum

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The stem bark of Oroxylum indicum (O. indicum) was aimed at testing for anti-inflammatory, antiulcerative, antihyperglycemic, and antidyslipidemic activities. Liver enzyme concentration (SGPT, SGOT) had also been assessed. After being extracted in organic solvent, 3 distinct doses, 100, 200, and 400 mg/kg b.w. (p.o.), were used. For edema formation 0.1 ml carrageenan at a dose of 1% w/v was injected into paw of left hind. It showed a fall of edemas 37.50%, 48.34%, and 55.83% while used doses were 100, 200, and 400 mg/kg b.w. (p.o.) individually. The EtOH extract of O. indicum (50%) and its fractions PET, CLF, EtOAc, and nBUT were studied against ethanol-induced gastric mucosal damage. Only PET and n-BuOH exhibited the highest percentage of protection and were 96% and 99%, respectively, persuaded by ethanol. In OGTT glibenclamide revealed reduction of glucose level to 7.55 ± 0.22 mmol/L from 10.57 ± 0.32 mmol/L after 30 minutes. Antihyperglycemic activities were assessed for 8- and 12-week duration in diabetic rats. Glibenclamide reduced glucose level from 33.50±0.31 to 7.90±0.19 mmol/L in 12 weeks. In 12 and 8 weeks, combination therapy lowered blood glucose level to a normal extent by 79% and 61% individually. In antidyslipidemic activities after 12-week treatment, it revealed simvastatin; MEOI (400 mg/kg b.w.) and combination of both reduced TC level by 44%, 28%, and 48% consequently followed by TG and LDL. In 8-week treatment, HDL levels were increased by 34%, 13%, and 36%, and in 12 weeks increased by 36%, 8%, and 38% consequently. Liver enzyme concentration after 12 weeks of treatment with glibenclamide, 400 mg/kg b.w. (p.o.) of MEOI and combination of both, exhibited the fact that concentration of SGPT showed downturn by 43.23%, 8.01%, and 54.86% and SGOT by 42.40%, 5.31%, and 44.85%. This study remarked that O. indicum has anti-inflammatory, antiulcer, antidiabetic, and antidyslipidemic potentials but has no ameliorative effect on liver enzyme.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological Inspections of Organic Extract ofOroxylum indicumin Rat Models: A Promising Natural Gift

Begum

Islam

Begum

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Baicalein (C 15 H 10 O 5 ), also chemically known as 5,6,7-trihydroxyflavone, is a member of flavonoids compound, under flavones sub-groups with a structure based on the backbone 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one) ( Figure 2). demonstrated the abundance of baicalein isolated from various parts of this plant including the stem barks, root barks, leaves, fruits and also seeds [4][5][6][7][8]. Baicalein (C15H10O5), also chemically known as 5,6,7-trihydroxyflavone, is a member of flavonoids compound, under flavones sub-groups with a structure based on the backbone 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one) ( Figure 2).…”

Section: Baicalein-the Major Chemical Compound Found In O Indicummentioning

confidence: 97%

“…The biological activities reported in different parts of the O. indicum plant are mediated by a broad range of secondary metabolites, such as flavonoids, alkaloids, tannin, glycosides, saponin, phenols and quinones found in the O. indicum plant [4][5][6][7][8]. Among them, flavonoids are the major storage components of O. indicum which could be found in almost all parts of the plant using various types of extraction solvents including methanol, ethanol, chloroform, water, and ethyl acetate [4,[8][9][10][11][12][13]. The flavonoids constituents present in O. indicum includes baicalein, baicalein-7-O-glucosice, baicalein-7-O-diglucoside, chrysin, and oroxylin-A [14].…”

Section: Baicalein-the Major Chemical Compound Found In O Indicummentioning

confidence: 99%

“…Among all of these flavonoids, baicalein is the most abundantly found and dominant active compound of the O. indicum plant in general [9,14,15]. Numerous studies conducted on phytochemical investigations of O. indicum clearly demonstrated the abundance of baicalein isolated from various parts of this plant including the stem barks, root barks, leaves, fruits and also seeds [4][5][6][7][8].…”

Section: Baicalein-the Major Chemical Compound Found In O Indicummentioning

confidence: 99%

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The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review

et al. 2020

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In Southeast Asia, traditional medicine has a longestablished history and plays an important role in the health care system. Various traditional medicinal plants have been used to treat diseases since ancient times and much of this traditional knowledge remains preserved today. Oroxylum indicum (beko plant) is one of the medicinal herb plants that is widely distributed throughout Asia. It is a versatile plant and almost every part of the plant is reported to possess a wide range of pharmacological activities. Many of the important bioactivities of this medicinal plant is related to the most abundant bioactive constituent found in this plant—the baicalein. Nonetheless, there is still no systematic review to report and vindicate the biological activities and therapeutic potential of baicalein extracted from O. indicum to treat human diseases. In this review, we aimed to systematically present in vivo and in vitro studies searched from PubMed, ScienceDirect, Scopus and Google Scholar database up to 31 March 2020 based on keywords “Oroxylum indicum” and “baicalein”. After an initial screening of titles and abstracts, followed by a full-text analysis and validation, 20 articles that fulfilled all the inclusion and exclusion criteria were included in this systematic review. The searched data comprehensively reported the biological activities and therapeutic potential of baicalein originating from the O. indicum plant for anti-cancer, antibacterial, anti-hyperglycemia, neurogenesis, cardioprotective, anti-adipogenesis, anti-inflammatory and wound healing effects. Nonetheless, we noticed that there was a scarcity of evidence on the efficacy of this natural active compound in human clinical studies. In conclusion, this systematic review article provides new insight into O. indicum and its active constituent baicalein as a prospective complementary therapy from the perspective of modern and scientific aspect. We indicate the potential of this natural product to be developed into more conscientious and judicious evidencebased medicine in the future. However, we also recommend more clinical research to confirm the efficacy and safety of baicalein as therapeutic medicine for patients.

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Oroxylum indicum (L.) Kurz Bignoniaceae

Devanathan¹

2020

Ethnobotany of Mountain Regions

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Topical application of stem bark ethanol extract of Sonapatha, Oroxylum indicum (L.) Kurz accelerates healing of deep dermal excision wound in Swiss albino mice

Cited by 18 publications

References 45 publications

Ethnopharmacological Inspections of Organic Extract ofOroxylum indicumin Rat Models: A Promising Natural Gift

Ethnopharmacological Inspections of Organic Extract ofOroxylum indicumin Rat Models: A Promising Natural Gift

The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review

Oroxylum indicum (L.) Kurz Bignoniaceae

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