Wound healing activity of Calotropis gigantea root bark in rats

Deshmukh, Pradeep; Fernandes, J.; Atul, Akarte; Toppo, Emmanuel

doi:10.1016/j.jep.2009.06.007

Cited by 98 publications

(53 citation statements)

References 15 publications

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“…A standard wound of uniform 2 cm diameter was formed with the aid of a round seal [21][22][23][24] . The treatment to the excision wounds of the rats was the same as described above.…”

Section: Excision Wound Modelmentioning

confidence: 99%

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Murti

Kumar²

2012

Asian Pacific Journal of Tropical Biomedicine

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“…A standard wound of uniform 2 cm diameter was formed with the aid of a round seal [21][22][23][24] . The treatment to the excision wounds of the rats was the same as described above.…”

Section: Excision Wound Modelmentioning

confidence: 99%

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Murti

Kumar²

2012

Asian Pacific Journal of Tropical Biomedicine

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“…11,12 Traditionally, the root of Calotropis gigantea is used in treatment of leprosy, asthma, bronchitis, and as an expectorant. 13,14 Calotropis gigantea reported to exhibit free radical scavenging 15,16 and pro-coagulation activity, 17 pregnancy interceptive, 18 anticancer, 19 immunomodulatory, 20 wound healing, 21 anti-inflammatory [22][23][24][25] and hepatoprotective 16,26 activity.…”

Section: Introductionmentioning

confidence: 99%

Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

Sanyal¹,

Maity²,

Pradhan³

et al. 2016

Toxicol Forensic Med Open J

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“…23,[32][33][34] Due to the paucity of data in support on the traditional Bhawan Pvt. Ltd., Nagpur) purchased from market were used as positive controls for the wound healing evaluation.…”

Section: Resultsmentioning

confidence: 99%

Wound Healing Efficacy of Mimusops Elengi L. Flowers in Albino Wistar Rats using Excision Wound Model

Shailajan¹,

Gurjar²

2016

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Introduction: Mimusops elengi L. (Sapotaceae), known as Bakul in Ayurveda, is an evergreen tree found throughout India. M. elengi flowers (MEF) are reported to possess immunomodulatory, hepatoprotective, skin whitening, anti-anxiety and wound healing activities which may be attributed to its phytochemical constituents including triterpenoids, alkaloids, phenolics, volatile oils, etc. Although the flowers have been traditionally used as a wound healing agent, there is a paucity of scientific data in support of its efficacy. Methods: An ethanolic extract of MEF was evaluated for its wound healing potential in male Albino Wistar rats using an excision wound model. The ethanolic extract of MEF was standardized in terms of its gallic acid content using a validated HPTLC technique. The antioxidant activity of MEF was also evaluated in vitro. The wound healing potential of the ethanolic extract of MEF was studied on the basis of wound contraction data, epithelialization period, the effect on biochemical parameters from the granulation tissue and histopathological observations. The results were compared with the traditional drug Jatyadi Taila (JT) and the modern drug Betadine (BTD). Results: Topical application of the standardized ethanolic extract of MEF on excision wounds caused a significantly faster reduction in the wound area as compared to JT and BTD. Similarly, it also showed the significant increase in the tissue hydroxyproline, hexosamine and protein biochemical parameters when compared with the untreated control. Conclusion:The findings of the present study provide data on wound healing and antioxidant potential of MEF and supports their traditional therapeutic claim.

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Wound healing activity of Calotropis gigantea root bark in rats

Cited by 98 publications

References 15 publications

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

Wound Healing Efficacy of Mimusops Elengi L. Flowers in Albino Wistar Rats using Excision Wound Model

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