Working memory in siblings of schizophrenia patients

Barrantes‐Vidal, Neus; Aguilera, Mari; Campanera, S.; Fatjó‐Vilas, Mar; Guitart, Marc; Miret, Salvador; Valero, Sergi; Fañanás, Lourdes

doi:10.1016/j.schres.2007.06.020

Cited by 59 publications

(39 citation statements)

References 37 publications

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“…This is in line with the evidences reporting that patients with depression produce fewer words on fluency tasks (Fossati et al 2003). From an intermediate phenotypes framework, it is of mention that these cognitive deficits have also been found in healthy first degree relatives of patients with either MDD or SZ (Christensen et al 2006;Barrantes-Vidal N, 2007). Thus, our findings could support the importance of studying executive functions performance as a vulnerability marker for depression in the general population.…”

Section: Discussionsupporting

confidence: 91%

Role of neurotrophins in depressive symptoms and executive function: Association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample

Prats

Arias

Ortet

et al. 2017

Journal of Affective Disorders

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word count: 248Word count: Tables: 3 Figures: 2 Number of references: ABSTRACT Background: Neuritin-1 (NRN1) is a neurotrophic factor involved in synaptic plasticity that has been associated with schizophrenia, depressive disorders and cognitive performance. Considering that the study of genotype-phenotype relationship in healthy individuals is a useful framework to investigate the etiology of brain dysfunctions that underlie mental disorders, we aimed to study in a general population sample, whether NRN1 gene variability is contributing to: i) the psychopathological profile, ii) the executive function performance. We also aimed to test whether these associations are modulated by BDNF gene.

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Section: Discussionsupporting

confidence: 91%

Role of neurotrophins in depressive symptoms and executive function: Association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample

Prats

Arias

Ortet

et al. 2017

Journal of Affective Disorders

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“…Memory function was found to be impaired in bipolar patients and their relatives [20,83,128] and in schizophrenic patients as well [71,91,131]. Moreover, working memory and executive functions have been claimed to be promising endophenotypes through which early signs of psychotic disease can be detected [12,16]. Finally, the conditioning events related to the activation of the amygdala have been associated with psychiatric disorders in a consistent number of reports (reviewed in Quirk and Gehlert [127]).…”

Section: Implications For Psychiatric Disordersmentioning

confidence: 96%

HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory

Drago

Alboni

Brunello

et al. 2009

Eur J Clin Pharmacol

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Purpose Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. We review the characteristics of the gene coding for HTR1B, its product and the functional role of HTR1B in the neural networks involved in motivation and memory; the central role played by HTR1B in these functions is thoroughly depicted and show HTR1B to be a candidate modulator of the mnemonic and motivationally related symptoms in psychiatric illnesses. Methods In order to challenge this assessment, we analyze how and how much the genetic variations located in the gene that codes for HTR1B impacts on the psychiatric phenotypes by reviewing the literature on this topic. Results We gathered partial evidence arising from genetic association studies, which suggests that HTR1B plays a relevant role in substance-related and obsessive compulsive disorders. On the other hand, no solid evidence for other psychiatric disorders was found. This finding is quite striking because of the heavy impairment of motivation and of mnemonic-related functions (for example, recall bias) that characterize major psychiatric disorders. Conclusions The possible reasons for the contrast between the prime relevance of HTR1B in regulating memory and motivation and the limited evidence brought by genetic association studies in humans are discussed, and some suggestions for possible future directions are provided.

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“…11,12 Şizofreni hastalarında saptanan bilişsel kusurlar (zihin kuramı, yürütücü işlevler, dikkat, sözel akıcılık gibi) hastaların akrabalarında da hafif düzeyde saptanmıştır. [13][14][15][16] Son yıllarda yapılan araştırmalarda yaş, eğitim durumu, yakınlık derecesi, zeka gibi değişkenler kontrol edildiğinde hastalıktan etkilenmemiş birinci derece şizofreni akrabalarının bilişsel bozuklukları değerlendiren testlerde sağlıklı kontroller ile benzer performans gösterdikleri saptanmıştır. 11 Oksitosin (OT), hipotalamusun supraoptik ve paraventrikuler çekirdeklerinden salgılanan bir hormondur.…”

Section: Introductionunclassified

The comparison of executive functions, social cognition and plasma oxytocin level between mothers of schizophrenia patients and healthy control: Searching for a new endophenotype

Aydın¹,

Balıkçı²,

Taş³

et al. 2017

Anadolu Psikiyatri Derg

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Working memory in siblings of schizophrenia patients

Cited by 59 publications

References 37 publications

Role of neurotrophins in depressive symptoms and executive function: Association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample

Role of neurotrophins in depressive symptoms and executive function: Association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample

HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory

The comparison of executive functions, social cognition and plasma oxytocin level between mothers of schizophrenia patients and healthy control: Searching for a new endophenotype

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