HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory

Abstract

Purpose Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. We review the characteristics of the gene coding for HTR1B, its product and the functional role of HTR1B in the neural networks involved in motivation and memory; the central role played by HTR1B in these functions is thoroughly depicted and show HTR1B to be a candidate modulator of the mnemonic and motivationally related symptoms in psychiatric illnesses. Methods In order to challenge this assessment, we analyze how and how much the genetic variations located in the gene that codes for HTR1B impacts on the psychiatric phenotypes by reviewing the literature on this topic. Results We gathered partial evidence arising from genetic association studies, which suggests that HTR1B plays a relevant role in substance-related and obsessive compulsive disorders. On the other hand, no solid evidence for other psychiatric disorders was found. This finding is quite striking because of the heavy impairment of motivation and of mnemonic-related functions (for example, recall bias) that characterize major psychiatric disorders. Conclusions The possible reasons for the contrast between the prime relevance of HTR1B in regulating memory and motivation and the limited evidence brought by genetic association studies in humans are discussed, and some suggestions for possible future directions are provided.

Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features

“…Supervised clustering analysis with Bonferroni correction revealed that only 1 of the 202 tumor-specific CpG sites was differentially methylated between these tumor groups (HTR1B_P222_F, upregulated in BRAF mutant tumors, p = 8.1 × 10 -6 ). HTR1B (5-hydroxytryptamine (serotonin) receptor 1B) is a G protein-coupled multi-pass membrane protein involved in regulation of the serotonin system [37]. The gene is hypermethylated in lung cancer and its chromosome locus (16q14.1) is frequently deleted in a number of cancer types [38].…”

Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development

“…Genetic studies implicate a link between 5-HT 1B Rs and substance abuse (Cao et al, 2013; Drago et al, 2010; Hasegawa et al, 2002; Huang et al, 2003; Proudnikov et al, 2006; Sun et al, 2002); but see (Cigler et al, 2001; Proudnikov et al, 2006), suggesting that the dysregulation of 5-HT 1B Rs may be a critical part of substance abuse pathology. 5-HT 1B Rs are terminal autoreceptors on 5-HT neurons (Boschert et al, 1994; Doucet et al, 1995; Voigt et al, 1991), as well as heteroreceptors on medium spiny GABAergic neurons originating in striatum and projecting to the ventral pallidum, ventral tegmental area (VTA), and substantia nigra (Bruinvels et al, 1994; Ghavami et al, 1999; Riad et al, 2000; Sari et al, 1997; Sari et al, 1999).…”

Proximal Deletion of 6q Overlapping with Toriello-Carey Facial Phenotype: Prenatal Findings, Clinical Course, Differential Diagnosis, and Review

“…The HTR1B gene (6q14.1) encodes a serotoninergic receptor that has been associated with behavior and psychiatric disorders [Drago et al, 2010], but the association with neurodevelopmental delay remains elusive.…”