WITHDRAWN: Association between <i>ADIPOQ</i> rs2241766 polymorphism and risk of diabetic nephropathy

Zhu, Hanyu; Zhang, Dong; Wang, Geng; Ying, Zheng; Wu, Jie; Dong, Zheyi; Zhang, Weiguang; Xiao, Fenglin; Liu, Moyan; Li, Zuoxiang; Duan, Shuwei; Cai, Guangyan; Chen, Xiangmei

doi:10.18632/oncotarget.19834

Cited by 1 publication

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References 35 publications

(48 reference statements)

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“…It was also displayed that the +276 G/T (rs1501299) polymorphism of the ADIPOQ gene is associated with the risk of obesity in Caucasians [ 22 ]. The pathogenesis of nephropathy is tightly bound to glucose toxicity, increased blood pressure, and cholesterol levels, which, as mentioned earlier, were associated with the GG genotype of the ADIPOQ gene (+45T > G rs2241766) [ 23 ]. It was also discovered that the GG genotype of the ADIPOQ polymorphism (+45T > G rs2241766) is associated with the phenotypes of hypertension and dyslipidemia in Asian populations [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Polymorphism in Adiponectin and Adiponectin Receptor Genes in Diabetes Mellitus Pathogenesis

et al. 2022

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The role played by hereditary factors in the development of diabetes mellitus type 2 (DM2) has not yet been fully established. Therefore, the purpose of our study was to investigate the prevalence of adiponectin and polymorphism in its gene receptors in connection with the primary symptoms of DM2 pathogenesis. Genomic DNA was isolated from the whole blood of 94 patients with an established diagnosis of DM2 using the phenol–chloroform method. Gene polymorphisms were determined using real-time polymerase chain reaction (PCR). The most common polymorphic variants in patients with DM2 were the genotypes AA (rs11061971) and GG (rs16928751) on the ADIPOR2 gene. A strong correlation was found between the rs16928751 polymorphism on the ADIPOR2 gene and increased body mass index (BMI). TG (rs2275737) ADIPOR1 gene genotype carriers were found to have the highest levels of glycosylated hemoglobin (HbA1), whereas TT (rs2275738) caused stable hyperglycemia. In addition, the rs16928751 ADIPOR2 gene polymorphism showed an association with the development of key mechanisms of DM2 in the Russian population, although a number of genomic searches failed to show any association of this gene with DM2. Unique gene variants associated with the risk of developing DM2 in the Crimean population were established.

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Section: Discussionmentioning

confidence: 99%

Polymorphism in Adiponectin and Adiponectin Receptor Genes in Diabetes Mellitus Pathogenesis

et al. 2022

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WITHDRAWN: Association between ADIPOQ rs2241766 polymorphism and risk of diabetic nephropathy

Abstract: Background: This meta-analysis was performed to derive a more comprehensive

Cited by 1 publication

References 35 publications

Polymorphism in Adiponectin and Adiponectin Receptor Genes in Diabetes Mellitus Pathogenesis

Polymorphism in Adiponectin and Adiponectin Receptor Genes in Diabetes Mellitus Pathogenesis

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