Wirksamkeit und Verträglichkeit eines standardisierten Weidenrindenextraktes bei Arthrose-Patienten: Randomisierte, Placebo-kontrollierte Doppelblindstudie

Abstract

Willow bark extract shows a moderate analgesic effect in osteoarthritis.

The Role of Organic Small Molecules in Pain Management

“…Complex ancient preparations used for centuries, such as the Shiyifang Vinum containing 13 herbs, have been employed to treat pain and inflammation [ 16 ]. One of the first anti-inflammatory treatments described by ancient civilizations, such as Egyptians, Greeks, Sumerians and Chinese, was the use of the willow bark [ 17 , 18 , 19 ]. Preparations of Salix species have been used for centuries to alleviate pain and to treat fever and rheumatic conditions [ 17 , 18 , 19 , 20 ].…”

“…One of the first anti-inflammatory treatments described by ancient civilizations, such as Egyptians, Greeks, Sumerians and Chinese, was the use of the willow bark [ 17 , 18 , 19 ]. Preparations of Salix species have been used for centuries to alleviate pain and to treat fever and rheumatic conditions [ 17 , 18 , 19 , 20 ]. Its principal active ingredient is called salicin, which is used as a prodrug of salicylate [ 21 ].…”

“…Salicylic acid was obtained from hydrolysis followed by oxidation of salicin. An acetylated derivative of salicylic acid became one of the most important drugs in the world, aspirin ( Figure 1 ) [ 17 ]. The effectiveness and safety profile of herbal medicines such as willow bark extract is of great interest.…”

“…The effectiveness and safety profile of herbal medicines such as willow bark extract is of great interest. In this sense, the ethanolic extract showed to be effective and safe to treat low back pain [ 21 , 22 ], and it showed a moderate analgesic effect against osteoarthritis [ 17 ]. The action of willow bark extract as an anti-inflammatory agent was compared to celecoxib and acetylsalicylic acid, and it was found to be as effective as these drugs [ 23 ].…”

Salicylatreiche Weiden für die Arzneimittelherstellung

“…Durch aktuelle medizinische Studien, in denen die Wirksamkeit der Weidenrinde gegen rheumatische Beschwerden, Fieber und Kopfschmerzen belegt wurde, gelangte die Weidenrinde wieder zu einer erhöhten Aufmerksamkeit. Besonders in den vergangenen zehn Jahren belegen viele Veröffentlichungen die Wirksamkeit gegen Rheumaerkrankungen und Arthrose (Chrubasik et al 2000Schmid et al 2000;Lardos et al 2004). Die positiven Effekte der Weidenrinde werden auf einen Wirksynergismus der vielfältigen sekundären Pflanzeninhaltsstoffe wie den Phenolglykosiden, den Flavonoiden und den Gerbstoffen zurückgeführt (Chrubasik u. Pollak 2002;Hegnauer 1973).…”