Salicylatreiche Weiden für die Arzneimittelherstellung

Comprehensive analysis of commercial willow bark extracts by new technology platform: Combined use of metabolomics, high-performance liquid chromatography–solid-phase extraction–nuclear magnetic resonance spectroscopy and high-resolution radical scavenging assay

“…Several studies have focused on phytochemical investigation of Salix species used for preparing the final willow bark products, and, e.g., Salix daphnoides, Salix pentadra, Salix purpurea, Salix alba, and Salix fragilis have been investigated for their content of phenolic glycosides [9][10][11]. In addition to salicylates, flavonoids and condensed tannins constitute the major groups of secondary metabolites in Salix species, and these compounds are believed to contribute to the analgesic and anti-inflammatory effect of willow bark [12,13].…”

Targeted Chemoprofiling and Bioactivity Screening of Willow Bark

“…This shows that I may be effective reducing nitric oxide, but not PGE2 levels. In contrast, high content of III in S. pentandra has been already revealed (Förster et al 2021, Förster et al 2009, Ruuhola, Julkunen-Tiitto, and Vainiotalo 2003. Particularly, in methanol extract of micropropagated S. pentandra leaves, 1 (~3 mg/g FW), 3 (~2 mg/g FW), I (~1 mg/g FW), V (~4 mg/g FW), and VII (~0.90 mg/g FW) besides high abundant III compound (~10 mg/g FW) could be quantified performing HPLC-DAD analysis Sorsa 2001, Ruuhola, Julkunen-Tiitto, andVainiotalo 2003).…”

“…UV, IR, FAB-MS, and NMR showed that bark of S. pentandra contains salicylates, like 1, 7, 11, and 5, and flavonoids, such as grandidentatin, triandrin, and ampelopsin (Shao et al 1989). Quantitative analysis has been performed on three different Salix clones, showing high amounts of 7 in S. purpurea and S. daphnoides, and of 5 in S. pentandra among various other available compounds (Förster et al 2009). Investigations using mass spectrometry and NMR analysis, showed that the compound purpurein was available in S. purpurea bark material (Pearl and Darling 1970b).…”

Deacetylation of per-acetatylated glycopyranosides: An overall pattern for acidic catalyzis

“…Recently we showed the use of methoxyphenyl 2-O-acetyl galactopyranoside as glycosyl acceptor in sialylation reaction [20] which gave good yield and selectivity. Such compounds also provide diverse biological activities [21,22] and can be used for drug design.…”