Wireless theranostic smart contact lens for monitoring and control of intraocular pressure in glaucoma

Kim, Tae Yeon; Mok, Jeewon; Hong, Sang Hoon; Jeong, Sang Hoon; Choi, Heung‐Jin; Shin, Sangbaie; Joo, Choun‐Ki; Hahn, Sei Kwang

doi:10.1038/s41467-022-34597-8

Cited by 48 publications

(47 citation statements)

References 43 publications

(57 reference statements)

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“…Photolithography is an extensively used fabrication technique in SCLs, and it enables the creation of precise patterns and structures on the surface of a lens. , The process involves transferring a pattern onto a light-sensitive substrate using light, followed by removing the soluble areas with a chemical developer.…”

Section: Technologies Overviewmentioning

confidence: 99%

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Seo,

Chung,

Kwon

et al. 2023

Chem. Rev.

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The eye contains a complex network of physiological information and biomarkers for monitoring disease and managing health, and ocular devices can be used to effectively perform point-of-care diagnosis and disease management. This comprehensive review describes the target biomarkers and various diseases, including ophthalmic diseases, metabolic diseases, and neurological diseases, based on the physiological and anatomical background of the eye. This review also includes the recent technologies utilized in eyewearable medical devices and the latest trends in wearable ophthalmic devices, specifically smart contact lenses for the purpose of disease management. After introducing other ocular devices such as the retinal prosthesis, we further discuss the current challenges and potential possibilities of smart contact lenses.

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Section: Technologies Overviewmentioning

confidence: 99%

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Seo,

Chung,

Kwon

et al. 2023

Chem. Rev.

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show abstract

“…With the help of a smartphone, the glucose levels in tears ranging from 23 μM to 1.0 mM could be effectively monitored using these e-CLs. Although there is no smart lens that can measure the pressure levels of the intraocular lens, Kim in 2022 was able to report an integrated smart lens for this purpose . According to their report, a theranostic smart CL was developed as shown in Figure a, with a highly accurate integrated system that includes a sensitive IOP sensor based on gold hollow nanowires (AuNW), a flexible drug delivery mechanism, wireless power and communication systems, as well as an application-specific integrated circuit chip .…”

Section: Current State Of E-cls Technologymentioning

confidence: 99%

“…(b) A diagram illustrating the typical method for continuously monitoring IOP and the use of IOP monitoring to control drug delivery on an as-needed basis for treating glaucoma. Reprinted with permission from ref . Copyright 2022 Springer Nature.…”

Section: Current State Of E-cls Technologymentioning

confidence: 99%

The Future of Vision: A Review of Electronic Contact Lenses Technology

et al. 2023

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The field of vision correction is constantly evolving to meet the increasing demand for more advanced and personalized solutions. Electronic contact lenses (e-CLs) are a new and emerging technology that has the potential to revolutionize this field and change the way we see and interact with the world. This Review provides a comprehensive overview of e-CL technology, including the current state of the technology, the different types of e-CLs that exist, and their benefits and limitations. It also discusses recent advancements and innovations in e-CL technology, as well as the various applications of e-CLs in healthcare, sports, and entertainment. Safety and ethical considerations surrounding the use of e-CLs are also addressed. Additionally, the Review offers an outlook on the future of e-CL technology and explores how these devices may change the way we interact with technology and the world around us. Overall, this Review aims to provide a comprehensive understanding of e-CL technology and its potential impact on the field of vision correction.

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“…The system can be used to deliver timolol at any time for intraocular pressure control. The developed theranostic smart CL is a good system that can be used as a futuristic personal health platform for glaucoma and other ocular diseases [ 86 ].…”

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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Wireless theranostic smart contact lens for monitoring and control of intraocular pressure in glaucoma

Cited by 48 publications

References 43 publications

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

The Future of Vision: A Review of Electronic Contact Lenses Technology

Application of Convergent Science and Technology toward Ocular Disease Treatment

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