Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization

Li, Changhao; Xiao, Cairong; Zhan, Lizhen; Zhang, Zhekun; Xing, Jun; Zhai, Jinxia; Zhou, Zhengnan; Tan, Guoxin; Piao, Jinhua; Zhou, Yahong; Qi, Suijian; Wang, Zhengao; Yu, Peng; Ning, Chengyun

doi:10.1016/j.bioactmat.2022.03.027

Cited by 25 publications

(33 citation statements)

References 60 publications

(63 reference statements)

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“…The enhanced regeneration of the wounded skin tissue can be attributed to the ability of BiOCl nanosheets with light-induced surface potential regulation, which can rationally switch between antibacterial priority and proliferation priority. When the photoelectric nanosheets adhere to the wound surface, they dynamically reconstruct bacterial and bioactive electro-microenvironments [ 34 , 35 ], which promotes enhanced wound healing. In the past few years, various antibacterial agents, such as ion incorporated nanoparticles, photothermal/photodynamic graphene and antibacterial polymers [ [36] , [37] , [38] ], have been developed for fighting tissue infection.…”

Section: Resultsmentioning

confidence: 99%

Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds

Ren¹,

Lin²,

Fan³

et al. 2022

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds

Ren¹,

Lin²,

Fan³

et al. 2022

Materials Today Bio

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“…Li et al created tetragonal-polarized BaTiO 3 (P-BTO) piezoelectric NPs with improved the electromechanical conversion efficiency for the electrical stimulation-induced normalization of tumor blood vessels under ultrasound (Figure 6a). [88] The results demonstrated that P-BTO NPs promoted normalization of blood vessels at the [83] Copyright 2018, Elsevier. b) Reproduced with permission.…”

Section: Antitumor Therapymentioning

confidence: 95%

Research Trends of Piezoelectric Nanomaterials in Biomedical Engineering

Yang

Shan

et al. 2022

Advanced NanoBiomed Research

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Piezoelectric nanomaterials are functional materials that hold a great promise for the nanoscale conversion of mechanical energy and electrical signals. Owing to their excellent electromechanical dependence, catalytic activity, and response sensitivity, piezoelectric nanomaterials are widely used in energy harvesting, sensors, actuators, resonators, and medical detectors. Nano‐piezoelectric materials exhibit unique electrical and chemical activities in the field of biomedical engineering, such as disease diagnosis and treatment. The working principles, device‐design mechanics, and classification of piezoelectric nanomaterials are systematically reviewed. Then, the recent advances in piezoelectric nanomaterials and their applications in tissue regeneration, antitumor/antibacterial therapy, cell force detection, controlled drug release, and pathological/physiological parameter monitoring are highlighted. Finally, the perspectives on the development of future smart piezoelectric nanomaterials, and how they can serve as a building block to inspire and impact the development of novel diagnosis and treatment applications, are presented.

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“…An analytical model of a single nanoparticle invested by US was developed by Marino and colleagues 20 . For the same purpose, nite element model (FEM) simulations have also been recently proposed 30,32,33 . We developed a new simpli ed analytical model based on Gauss's law (Supplementary information, section S2), nding that the voltage generated (V) can be expressed as:…”

Section: Stimulation Of Nanocomposite Hydrogel Through Dose-controlle...mentioning

confidence: 99%

Ultrasound stimulation of piezoelectric nanocomposite hydrogels boosts cartilage regeneration

Ricotti

Cafarelli

Manferdini

et al. 2022

Preprint

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Osteoarthritis implies a progressive degeneration of the whole joint. Cartilage is particularly affected, with inflammation playing a pivotal role1. In recent years, cartilage regeneration has been pursued through several bioengineering strategies and using different stem cell types2-6. Adipose -derived mesenchymal stromal cells (ASCs) constitute an intriguing and minimally invasive option. However, the use of ASCs for cartilage regeneration is hampered by a relatively inefficient expression of key chondrogenic markers7. Thus, new strategies to boost both in situ targeting and chondrogenesis of ASCs are highly desirable. Here we show that ASCs embedded in a nanocomposite hydrogel including piezoelectric nanomaterials and graphene oxide nanoflakes, and stimulated with ultrasound waves with precisely controlled parameters (1 MHz and 250 mW/cm2, for 5 min once every two days for a period of 10 days) dramatically boost cell chondrogenic commitment. Furthermore, this stimulation regimen also has a considerable anti-inflammatory effect. The proposed nanocomposite hydrogel also shows excellent biocompatibility in vivo. Our results show for the first time the chondrogenic potential of the combined piezoelectric nanoparticle-ultrasound stimulus; the proposed paradigm has the potential to trigger cartilage regeneration in osteoarthritis, focal cartilage defects and other pathological conditions involving cartilage lesions and degeneration. Future efforts should expand preclinical data, and target clinical applications of this therapeutic strategy.

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Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization

Cited by 25 publications

References 60 publications

Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds

Programmable biological state-switching photoelectric nanosheets for the treatment of infected wounds

Research Trends of Piezoelectric Nanomaterials in Biomedical Engineering

Ultrasound stimulation of piezoelectric nanocomposite hydrogels boosts cartilage regeneration

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