Research Trends of Piezoelectric Nanomaterials in Biomedical Engineering

Abstract

Piezoelectric nanomaterials are functional materials that hold a great promise for the nanoscale conversion of mechanical energy and electrical signals. Owing to their excellent electromechanical dependence, catalytic activity, and response sensitivity, piezoelectric nanomaterials are widely used in energy harvesting, sensors, actuators, resonators, and medical detectors. Nano‐piezoelectric materials exhibit unique electrical and chemical activities in the field of biomedical engineering, such as disease diagnosis and treatment. The working principles, device‐design mechanics, and classification of piezoelectric nanomaterials are systematically reviewed. Then, the recent advances in piezoelectric nanomaterials and their applications in tissue regeneration, antitumor/antibacterial therapy, cell force detection, controlled drug release, and pathological/physiological parameter monitoring are highlighted. Finally, the perspectives on the development of future smart piezoelectric nanomaterials, and how they can serve as a building block to inspire and impact the development of novel diagnosis and treatment applications, are presented.

Reactive oxygen species for therapeutic application: Role of piezoelectric materials

“…Thirdly, the consequence of the introduction of piezoelectric materials on immune responses and gene expression has not been mentioned in any recent studies todate. 167 Additionally, analogous to most nanomaterials for bio-medicinal application, bio-safety assessments, such as cytotoxicity and metabolism of the nanomaterials in the microenvironment, in addition to piezoelectric performance, are of critical importance. To challenge the tumor diseases, compared to ongoing dynamic therapies, another way to intensify the upcoming research process may be formulated by supportive ROS generation with both piezo-magneto or piezo-photo or piezo-pyro or piezo-tribo or piezoradio unification.…”

Printed Electronic Devices and Systems for Interfacing with Single Cells up to Organoids

“…[ 54 ] Barium titanate (BaTiO 3 ), a well‐known piezoelectric ceramic material, has been a primary focus of investigation. [ 55 ] Although not all printed piezoelectric materials are subsequently intended for applying mechanical stress or electric fields, these techniques demonstrate the feasibility of printing such systems and enable the development of novel devices that combine piezoelectric properties with printing methodologies.…”

Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro, in Both a Normal and Inflammatory Milieu

“…The wireless activation of piezoelectric nanomaterials through ultrasound (US) stimulation, locally generating electrical charges via the direct piezoelectric effect, has recently emerged as a promising paradigm for noninvasively triggering beneficial effects on cells and tissues. − …”