Winter savory: Supercritical carbon dioxide extraction and mathematical modeling of extraction process

Vladić, Jelena; Zeković, Zoran; Jokić, Stela; Svilović, Sandra; Kоvаčеvić, Strаhinjа; Vidović, Senka

doi:10.1016/j.supflu.2016.05.027

Cited by 33 publications

(28 citation statements)

References 39 publications

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“…Combination of increasing solutes vapour pressure and high diffusivity of the fluid has resulted in increased oil's solubility. Similar results were reported by several authors in their extraction of plant materials using the SC-CO 2 method [14], [22]. Table 2.…”

Section: Experimental Data Of Solubilitysupporting

confidence: 89%

“…In this work, various temperatures (40 to 60℃) and pressures (276 to 414 bar) were used to investigate their effect on solubility of C. vespertilionis oil in SC-CO 2 at constant flowrate of 24 mL/min and extraction time of 40 minutes. The extraction temperature and pressure used in this study has been chosen according to the previous literatures where the range used were from 40 to 60℃ of temperature and 200 to 414 bar of pressure has successfully been used for extraction of phytocompounds from plant materials [13], [14]. Once the system has been set to certain time, temperature and pressure, a dynamic valve was gently open to allow continuous flow of SC-CO 2 fluid.…”

Section: Supercritical Carbon Dioxide Extractionmentioning

confidence: 99%

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Solubility Modelling pf Butterfly Wing Leaves (Christia Vespertilionis) in Supercritical Carbon Dioxide

Hamid

Ismail²,

Mustapa³

et al. 2018

IJET

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Medicinal herb Christia vespertilionis oil has been claimed to possess anti-cancer and anti-plasmodial properties and show interest in food and pharmaceutical industries. Being an important alternative medicine plant, solubility data of Christia vespertilionis oil is demanded in order to understand the separation process and is crucial for designing purposes. In this work, extraction and determination of the oil's solubility were carried out using a green technique of supercritical carbon dioxide at a temperature range of 40 to 60℃ and 276 to 414 bar of pressure. The results demonstrated that the highest solubility was obtained at the highest temperature and pressure of 60℃ and 414 bar, respectively. For solubility prediction, experimental data were modelled using four empirical density-based models: Chrastil, del Valle and Aguilera, Adachi and Lu, and Sparks et al. models. In general, all the models were able to predict the solubility of Christia vespertilionis oil in supercritical carbon dioxide. The best fitting showed that Adachi and Lu model gave the best correlation with the lowest %AARD value of 1.61%.

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Section: Experimental Data Of Solubilitysupporting

confidence: 89%

Section: Supercritical Carbon Dioxide Extractionmentioning

confidence: 99%

Solubility Modelling pf Butterfly Wing Leaves (Christia Vespertilionis) in Supercritical Carbon Dioxide

Hamid

Ismail²,

Mustapa³

et al. 2018

IJET

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“…The biological potential of waste materials has been previously studied, in the attempt to employ post-distillation waste material of aromatic plants, thus creating both economic and ecologic benefits [25]- [27]. Actually, after volatile oils removal, waste plant materials are still abundant in phenolic compounds, oligomers and flavonoid glycosides with various biological activities [28], therefore these compounds could still have an application [29], [30]. Nevertheless, herb-herb combination have been used for thousand years, but scientific evidence of therapeutic benefits and a potential synergic effect of different compounds is not well defined yet [31].…”

Section: Introductionmentioning

confidence: 99%

Fibroblast Proliferation and Migration in Wound Healing by Phytochemicals: Evidence for a Novel Synergic Outcome

et al. 2020

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Wound-healing is a dynamic skin reparative process that results in a sequence of events, including inflammation, proliferation, and migration of different cell types as fibroblasts. Fibroblasts play a crucial role in repairing processes, from the late inflammatory phase until the fully final epithelization of the injured tissue. Within this context, identifying tools able to implement cell proliferation and migration could improve tissue regeneration. Recently, plants species from all over the world are coming out as novel tools for therapeutic applications thanks to their phytochemicals, which have antioxidant properties and can promote wound healing. In this paper, we aimed at investigating antioxidant activity of waste extracts from different medicinal plants, endemic of the Mediterranean area, on fibroblast proliferation and wound healing. We determined the amount of total phenols and anti-oxidant activity by ABTS assay. We then evaluated the cytotoxicity of the compounds and the proliferative capabilities of fibroblasts by scratch assay. Our results showed that waste extracts retain antioxidant and regenerative properties, inducing tissue re-establishment after environmental stress exposure. Taken together, our findings suggest that waste material could be used in the future also in combinations to stimulate wound healing processes and antioxidant responses in damaged skin.

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“…Considering the fact that carbon dioxide is a solvent with an affinity for non-polar compounds, in the other study water/ethanol mixture was chosen as a solvent because of its affinity for polar compounds. Liquid ethanol-water extract was then converted into dry form via spray drying technology (Vladić et al, 2016). Selected extracts of S. montana obtained in previously mentioned studies were selected for investigation in this study (Vidović et al, 2014;Vladić et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Liquid ethanol-water extract was then converted into dry form via spray drying technology (Vladić et al, 2016). Selected extracts of S. montana obtained in previously mentioned studies were selected for investigation in this study (Vidović et al, 2014;Vladić et al, 2016). Therefore, the main aim of this study was to assess the hepatoprotective potential of S. montana extracts in a mouse model of carbon tetrachloride (CCl 4 ) induced liver toxicity.…”

Section: Introductionmentioning

confidence: 99%

Assessment of antioxidant and hepatoprotective potential of Satureja montana extracts against CCl4 induced liver damage

Ćebović¹,

Vladić

Gavarić³

et al. 2019

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The influence of Satureja montana extracts on several liver biochemical parameters in mice administered with carbon tetrachloride was estimated. In vivo investigation of antioxidant properties of S. montana extracts encompassed monitoring of biochemical parameters (derived from liver homogenate and blood hydrolyzate) and examination of potential hepatoprotective effect after intoxication with carbon tetrachloride. Biochemical tests included determination of activity of several antioxidant enzymes: xanthine oxidase, catalase, peroxidase, glutathione peroxidase, amount of reduced glutathione and intensity of lipid peroxidation. In order to obtain data about the potent hepatoprotective effect of examined extracts, the following parameters were determined: aspartate aminotransferase, alanine aminotransferase, bilirubin, hepatic DNA and hydroxyprolin. Results of this study demonstrate that S. montana extracts inhibited the hepatotoxicity produced by carbon tetrachloride administration most probably through activation of physiological common defense mechanisms.

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Winter savory: Supercritical carbon dioxide extraction and mathematical modeling of extraction process

Cited by 33 publications

References 39 publications

Solubility Modelling pf Butterfly Wing Leaves (Christia Vespertilionis) in Supercritical Carbon Dioxide

Solubility Modelling pf Butterfly Wing Leaves (Christia Vespertilionis) in Supercritical Carbon Dioxide

Fibroblast Proliferation and Migration in Wound Healing by Phytochemicals: Evidence for a Novel Synergic Outcome

Assessment of antioxidant and hepatoprotective potential of Satureja montana extracts against CCl4 induced liver damage

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