This study investigates the wind effect on hexa-sectored scallop domes using Computational Fluid Dynamics (CFD) and wind tunnel tests. Similar to the shape of a seashell, the scallop dome is one of the most common domes used to cover large spans. The scallop dome has an additional curvature equal to its sectors compared to a base dome (spherical). Hence, it has better structural efficiency compared to a spherical dome under the same condition. The curvatures on the scallop dome create alternate “ridges” and “grooves” on it. According to the computations of the article, the grooves created on this dome in the sector, as well as their position angle to the wind direction significantly affect pressure coefficient value. Due to these differences, wind pressure on scallop domes significantly differs from wind pressure on spherical domes. The results indicate that the ridges cause negative wind pressure coefficients whose magnitude reaches a maximum of −2.0 for an angle of alignment of 30°. The analyses have been conducted through Ansys-Fluent. This study presents the equation of wind pressure coefficient in the most critical of dome groove positions. The arch created between the grooves of a scallop dome is another effective parameter on maximum negative pressure. In the case study scallop dome, if the wind effect angle is considered α = 15, the maximum deformation in the structure will be created, which is 20% higher than that of α = 0.