Widespread Choroidal Insufficiency in Primary Open-Angle Glaucoma

Glaucoma and ocular blood flow: an anatomical perspective

“…Blood flow parameters in OAG patients have been shown to be reduced in the retrobulbar [33], retinal [34], optic nerve head (ONH) [35] and choroidal [36] circulations. These vascular deficits may be one of the first manifestations of glaucoma [37,38].…”

Ischemic model of optic nerve injury

“…18,19 Other studies of glaucoma patients have shown abnormalities in blood rheology with increased blood viscosity and reduced erythrocyte deformability. 7,[20][21][22][23][24] In addition to the above clinical associations, a variety of experimental and clinical observations demonstrate circulatory aberrations of the anterior optic nerve, the peripapillary region, [25][26][27][28][29] the choroid, 27,30,31 and the retrobulbar vasculature [32][33][34][35][36][37][38][39][40] in eyes with GON. 33,[40][41][42][43] These apparent alterations in the circulation of the glaucomatous optic nerve may implicate dysfunction of vascular regulatory mechanisms.…”

Evaluation of peripapillary choroidal and retinal nerve fiber layer thickness in eyes with tilted optic disc

“…A thinner choroid may be important because it may make this area more susceptible to retinal and choroidal diseases (15) . This idea is favored by eyes with glaucoma wherein the choroid was reported to be thinner and the observation of more severe field defects in the thinner hemifield in glaucomatous eyes (16) . Reported disorders such as subretinal neovascularization and chorioretinal degenerative changes in the tilted disc syndrome (3) may be associated with thinner choroid next to the depressed part of the optic disc.…”