Wide QRS‐T angles are associated with markers of increased inflammatory activity independently of hypertension and diabetes

Sandstedt, Mikael; Bergfeldt, Lennart; Sandstedt, Joakim; Lundqvist, Annika; Fryk, Emanuel; Jansson, Per‐Anders; Bergström, Göran; Hultén, Lillemor Mattsson

doi:10.1111/anec.12781

Cited by 5 publications

(5 citation statements)

References 40 publications

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“…(2) IL‐6 might also cause sudden cardiac death (SCD) through other mechanisms such as acting with direct electrophysiological effects. In detail, Inflammatory cytokines including the IL‐6 could regulate the sympathetic tone and lead to poor heart rate variability, tachycardia, and cardiac electrical instability, contributing to SCD 48,49 . Hence, increased IL‐6 levels were related to elevated cardiovascular mortality risk in dialysis patients in our pooled analysis.…”

Section: Discussionmentioning

confidence: 84%

Interleukin‐6 levels can be used to estimate cardiovascular and all‐cause mortality risk in dialysis patients: A meta‐analysis and a systematic review

Chen

Wang

2023

Immunity Inflam & Disease

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Background Although previous studies have explored the correlation of interleukin (IL)−6 with mortality risk in dialysis patients, the findings have been conflicting. Hence, this meta‐analysis aimed to comprehensively assess the use of IL‐6 measurement for estimating cardiovascular mortality and all‐cause mortality in dialysis patients. Methods The Embase, PubMed, Web of Science, and MEDLINE databases were searched to identify relevant studies. After screening out the eligible studies, the data were extracted. Results Twenty‐eight eligible studies with 8370 dialysis patients were included. Pooled analyses revealed that higher IL‐6 levels were related to increased cardiovascular mortality risk (hazard ratio [HR] = 1.55, 95% confidence interval [CI]: 1.20–1.90) and all‐cause mortality risk (HR = 1.11, 95% CI: 1.05–1.17) in dialysis patients. Further subgroup analyses suggested that higher IL‐6 levels were associated with elevated cardiovascular mortality in hemodialysis patients (HR = 1.59, 95% CI: 1.36–1.81) but not in peritoneal dialysis patients (HR = 1.56, 95% CI: 0.46–2.67). Moreover, sensitivity analyses indicated that the results were robust. Egger's test revealed potential publication bias among studies exploring the correlation of IL‐6 levels with cardiovascular mortality (p = .004) and all‐cause mortality (p < .001); however, publication bias was not observed when using Begg's test (both p > .05). Conclusions This meta‐analysis reveals that higher IL‐6 levels could indicate higher risks of cardiovascular mortality and all‐cause mortality in dialysis patients. These findings suggest that monitoring IL‐6 cytokine may help to enhance dialysis management and improve the general prognosis of patients.

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Section: Discussionmentioning

confidence: 84%

Interleukin‐6 levels can be used to estimate cardiovascular and all‐cause mortality risk in dialysis patients: A meta‐analysis and a systematic review

Chen

Wang

2023

Immunity Inflam & Disease

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“…Сравнительно недавно в шведском исследовании SCAPIS (Swedish CArdioPulmonary bioImage Study) показано, что увеличение sQRS-Ta положительно связано не только с АГ, мужским полом, возрастом, ИМТ, но и с наличием сахарного диабета, концентрацией глюкозы натощак, уровнем гликированного гемоглобина и рядом лабораторных и цитологических показателей воспаления, включая уровень СРБ [15]. Результаты проведенного нами однофакторного анализа не противоречат выводам авторов (таблица 3).…”

Section: Discussionunclassified

Associations of increased spatial QRS-T angle with cardiovascular risk factors: data from the regional sample of ESSE-RF study

Муромцева¹,

Aidu²,

Макарова

et al. 2021

Cardiovasc Ther Prev

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Aim. To study the associations of increased spatial QRS-T angle (sQRS-Ta ≥90°) with cardiovascular risk factors (RFs).Material and methods. We analyzed 1411 electrocardiography (ECG) records of men and women aged 25-64 years from a random regional sample of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. Relationships of sQRS-Ta with the following RFs were assessed: hypertension (HTN), systolic blood pressure (SBP) ≥140 mm Hg, diastolic BP (DBP) ≥90 mm Hg, pulse pressure (PP) ≥60 mm Hg; glucose ≥7,0 mmol/l, hypercholesterolemia; hypertriglyceridemia; high-density lipoprotein cholesterol (HDL-C) ≤1,0/1,2 mmol/l in men/women, low-density lipoprotein cholesterol (LDL-C) >3,0 mmol/l; C-reactive protein (CRP) >1 mg/L; overweight, obesity and abdominal obesity; heart rate (HR) >80 bpm; age >52 years.Results. Weak but significant correlations of sQRS-Ta with age (in women), SBP, DBP, PP, body mass index, waist circumference, lipids, glucose, CRP were revealed. Univariate logistic regression demonstrated significant associations of increased sQRS-Ta with HTN, elevated SBP and PP, overweight, obesity and abdominal obesity, hypercholesterolemia, elevated LDL-C and CRP, hyperglycemia, age >52 years and heart rate >80 bpm. There were no associations of increased sQRS-Ta with male sex, elevated DBP, smoking, hypertriglyceridemia, and low HDL-C levels. The sQRS-Ta associations characteristic of women was similar with associations found among the entire sample. Men with increased sQRS-Ta had no associations with any of analyzed RFs. In multivariate models, increased sQRS-Ta was associated with the following combination of RFs: age >52 years, heart rate >80 bpm, HTN, increased PP, overwaight, and male sex. According to direct stepwise selection among all subjects and in women, the main contribution to sQRS-Ta was made by SBP, age, HDL-C and heart rate.Conclusion. Despite the significance of stepwise regression model (p=0,0001), the low coefficient of determination R2 may indicate other not yet identified determinants with relevant associations with sQRS-Ta.

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“…The frontal QRS-T angle is an independent predictor of coronary atherosclerosis (Dogan and Kahraman, 2020). Moreover, a wide frontal QRS-T angle correlated positively with increased markers of inflammatory activity such as IL-1, Il-4, Il-6, and TNF-α, in hypertensive patients (Sandstedt et al, 2020).…”

Section: Effect Of Cae On Metabolic Disorders In Animal Modelsmentioning

confidence: 96%

Centella Asiatica Effect in A High Fat and Fructose Diet-Induced Model of Metabolic Disorder in Rats

Hasimun¹,

Mulyani²,

Zakaria³

et al. 2021

J Biochem Technol

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Centella asiatica (CA) has been reported to have a protective effect on cardiovascular disease and cardiovascular disease-related conditions. Frontal QRS-T angle is a non-invasive biomarker that can predict cardiovascular mortality and morbidity in all causes of death. This study aimed to establish the protective effect of CA in animal models of metabolic disorders and its effect on the risk of cardiac ischemia by measuring the wide frontal QRS-T angle in animal models induced by high-fructose and high-fat diets. The study was carried out on thirty male Wistar rats distributed in 6 groups (n=5): groups 1 and 2 received (distilled water), group 3 received captopril 2.5 mg/kg, group 4-6 received 50, 100, 200 mg/kg of CA leaf extract, respectively for 14 days. All groups except the normal group received a 40% high-fat diet and 25% fructose in drinking water for 28days. Test drugs begin to be administered on days 15-28. CA leaf extract showed an antihypertensive effect and reduced body weight and triglyceride level, as well as the risk of cardiac ischemia, which was significantly different in comparison to the control group (p <0.05). It was concluded that CA has an impact on reducing the risk of mortality and morbidity due to cardiovascular events in metabolic disorder.

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Wide QRS‐T angles are associated with markers of increased inflammatory activity independently of hypertension and diabetes

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 5 publications

References 40 publications

Interleukin‐6 levels can be used to estimate cardiovascular and all‐cause mortality risk in dialysis patients: A meta‐analysis and a systematic review

Interleukin‐6 levels can be used to estimate cardiovascular and all‐cause mortality risk in dialysis patients: A meta‐analysis and a systematic review

Associations of increased spatial QRS-T angle with cardiovascular risk factors: data from the regional sample of ESSE-RF study

Centella Asiatica Effect in A High Fat and Fructose Diet-Induced Model of Metabolic Disorder in Rats

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