Centella Asiatica Effect in A High Fat and Fructose Diet-Induced Model of Metabolic Disorder in Rats

Abstract

Centella asiatica (CA) has been reported to have a protective effect on cardiovascular disease and cardiovascular disease-related conditions. Frontal QRS-T angle is a non-invasive biomarker that can predict cardiovascular mortality and morbidity in all causes of death. This study aimed to establish the protective effect of CA in animal models of metabolic disorders and its effect on the risk of cardiac ischemia by measuring the wide frontal QRS-T angle in animal models induced by high-fructose and high-fat diets. The study was carried out on thirty male Wistar rats distributed in 6 groups (n=5): groups 1 and 2 received (distilled water), group 3 received captopril 2.5 mg/kg, group 4-6 received 50, 100, 200 mg/kg of CA leaf extract, respectively for 14 days. All groups except the normal group received a 40% high-fat diet and 25% fructose in drinking water for 28days. Test drugs begin to be administered on days 15-28. CA leaf extract showed an antihypertensive effect and reduced body weight and triglyceride level, as well as the risk of cardiac ischemia, which was significantly different in comparison to the control group (p <0.05). It was concluded that CA has an impact on reducing the risk of mortality and morbidity due to cardiovascular events in metabolic disorder.