Why do we need hospital pharmacy preparation?

Carvalho, Maria Helena Catelli de; Taylor, Kevin; Tuleu, Catherine

doi:10.1136/ejhpharm-2012-000191

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Compounding, the preparation of customized medications to meet the specific needs of individual patients, allows patients the benefit of a personalized treatment and represents an invaluable therapeutic alternative in dermatology [ 5 ]. Compounded medications may be personalized to include special combinations of active substances in particular concentrations, as well as to include specific raw materials or provide certain organoleptic characteristics adjusted to the patient’s skin type and disorder [ 6 ]. The use of compounded topical formulations has already proven successful in wound care [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Case Series: The Effectiveness of Fatty Acids from Pracaxi Oil in a Topical Silicone Base for Scar and Wound Therapy

Banov

Bassani

2014

Dermatol Ther (Heidelb)

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IntroductionWounding affects the integrity of the skin and can ultimately result in skin scarring. Current therapeutic goals of wound treatment focus on the reduction of scar formation and severity. However, scar formation itself varies not only between individuals based on factors such as ethnicity, but also within an individual based on the location of the wound. Therefore, the preparation of customized treatments for individual patients represents an important therapeutic goal in the fields of dermatology and wound healing. The objective of this study was to evaluate the usefulness of fatty acids found in pracaxi oil in a compounded topical anhydrous silicone base for wound and scar therapy.MethodsInitially, 21 patients with various surgical, traumatic, or burn wounds and scars were enrolled into this case series. Patients applied a compounded topical anhydrous silicone base containing pracaxi oil with or without additional active ingredients, including pentoxifylline, caffeine, tranilast, and mupirocin. Wound/scar photographs taken before and after application of the compounded pracaxi oil topical formulation (with/without additional ingredients) were reviewed and adjudicated by a blinded dermatology reviewer. Improvements in wound size, coloration, and overall appearance before and after treatment were determined. Patient satisfaction was assessed after application of compounded topical formulation using a self-report questionnaire distributed at the time of dispensing.ResultsA total of seven patients were considered available for analysis and were included in the study. In all seven cases, patients reported improvement in scar and wound attributes, including scar and wound size, severity, color, and pain associated with the scar or wound after application of the compounded medicine. On average, patients rated their satisfaction with treatment highly, with a mean score of 10 on a rating scale of 1–10. Retrospective review of wound/scar photographs demonstrated clinically relevant improvements in wound attributes as assessed by a dermatologist. Six of the seven wounds examined were considered “much improved” from baseline.ConclusionsApplication of a compounded anhydrous silicone base containing pracaxi oil alone or in combination with other active substances led to considerable improvements in wound healing and scar attributes and is a potentially useful option in the treatment of surgical, traumatic, or burn wounds and scars.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-014-0065-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Case Series: The Effectiveness of Fatty Acids from Pracaxi Oil in a Topical Silicone Base for Scar and Wound Therapy

Banov

Bassani

2014

Dermatol Ther (Heidelb)

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“…[38] These frequent practices in hospitals [39,40] are extended to other health centers. [41] There are many aspects to be solved in the extemporaneous formulations because they give heterogeneous practices from one pharmacy to another; therefore, there is no homogeneity in the preparation.…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

Quality Assessment in the Extemporaneous Pediatric Preparation of Powder Papers Containing Crushed Tablets of Spironolactone or Amiodarone

Carrillo¹,

Herrera²

2017

WJPR

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To elaborate the pediatric medicines the specifics of this population must be considered. Powder papers as extemporaneous formulations may be an option to provide dosing flexibility. The main objective of this research was to evaluate the quality of powder papers in its manual preparation stages and during the 60 days of storage. The results shown that a smaller than expected mass of tablets was distributed for the 40 papers at each formulation. The precision in the distribution performed by the crushed and pulverized tablet preparatory assistant reflected relative standard deviations ranging from 9 to 15%. On the start day, the uniformity of mass showed an inaccuracy reflected in several values outside the expected range, for all formulations. The accuracy of the tablets powder mass during storage at 60 days showed a ±10% of difference respect basal mass for papers with spironolactone 6,25 mg and the 15 and 75 mg amiodarone hydrochloride papers. For 10 mg of amiodarone hydrochloride formulation, random errors occurred outside the expected ranges at two sampling times. Powder adherence percentage was between the 10 and 20%. In conclusion, the preparation of four formulations in powder paper showed some errors which resulted in a significant loss of dose. A standardized operating procedure for the preparation of powder papers should be available taking into account the risk points of the manufacturing processes. It is advisable to enable the galenical section in hospital pharmacies and to have legislation regulating extemporaneous formulations in Costa Rica.

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“… 6 Compounded medications may be personalized to include special combinations of active substances in particular strengths, and can be adjusted to the patient’s skin type and underlying comorbidities. 7 In this case report, the outcome of a patient with a diabetic ulcer on the lower leg, who applied a topical anhydrous silicone base containing fatty acids from pracaxi oil compounded with 2% mupirocin, is presented.…”

Section: Introductionmentioning

confidence: 99%

Use of a topical anhydrous silicone base containing fatty acids from pracaxi oil in a patient with a diabetic ulcer

Simmons

Banov

2015

SAGE Open Medical Case Reports

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Objectives:The treatment of diabetic ulceration of the lower extremities is a complicated task due to the nature of the ulcer and potential underlying comorbidities. This report describes the case of a 61-year-old male patient with Type 2 Diabetes who presented with an ulcerative leg wound. The objective of this study was to evaluate the outcome of a topical compounded treatment.Methods:The patient applied a compounded medicine containing 2% mupirocin in a topical anhydrous silicone base containing fatty acids from pracaxi oil directly to the ulcer for 63 days, 3 times daily. This regimen was supplemented with exercise and an additional compounded medicine applied to the wound margins in order to increase circulation.Results:By the end of the application period, the patient’s ulcer was fully closed.Conclusion:A topical anhydrous silicone compounding base containing fatty acids from pracaxi oil may be useful in the treatment of patients with diabetic ulcers.

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Why do we need hospital pharmacy preparation?

Cited by 5 publications

References 3 publications

Case Series: The Effectiveness of Fatty Acids from Pracaxi Oil in a Topical Silicone Base for Scar and Wound Therapy

Case Series: The Effectiveness of Fatty Acids from Pracaxi Oil in a Topical Silicone Base for Scar and Wound Therapy

Quality Assessment in the Extemporaneous Pediatric Preparation of Powder Papers Containing Crushed Tablets of Spironolactone or Amiodarone

Use of a topical anhydrous silicone base containing fatty acids from pracaxi oil in a patient with a diabetic ulcer

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