Use of a topical anhydrous silicone base containing fatty acids from pracaxi oil in a patient with a diabetic ulcer

Simmons, Chris V; Banov, Fabiana; Banov, Daniel

doi:10.1177/2050313x15589676

Cited by 8 publications

(8 citation statements)

References 11 publications

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“…For the infection, physician prescribed ceftriaxone along with diclofenac sodium and cleared the infected wound from pus and applied duoderum dressing: a standard diabetic foot ulcers (DFU) dressing [17,18]. Modern approach for treating the DFU includes the use of topical anhydrous silicon base containing pracaxi oil; this medication can be compounded and can be tailored according to the need of the patient [19].…”

Section: Discussionmentioning

confidence: 99%

Complications Associated with Diabetes: A Case Study

Butt¹,

Tipu²,

Malik³

et al. 2017

Natl. j. health sci.

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Background:The current study has focused on the complications arising in a patient due to diabetes mellitus and how the patient's quality of life has been affected. The most feared complication of the disease is loss of lower limb due to infection and major cardiovascular complications.Objectives: Management of a patient with diabetes and cardiovascular complication with history of tuberculosis is studied along with antimicrobial interventions for curing the ulcer and reducing risk of amputation. Cardiovascular complication, one of the co-morbidity of diabetes, was also managed. Methods:After selection of the patient, consent from patient and approval from relevant authority were obtained, patient was kept under observation for a week.Case Presentation: Patient was admitted with complaints of: shortness of breath, palpitation, exertional dyspnea and a spreading right shin discharging foot ulcer. Conclusion:Patient was treated with antibiotics and ionotropic agent and indicated better rate of prognosis.

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Section: Discussionmentioning

confidence: 99%

Complications Associated with Diabetes: A Case Study

Butt¹,

Tipu²,

Malik³

et al. 2017

Natl. j. health sci.

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“…Pracaxi wood has little commercial value, although studies by Melo et al [ 49 ] reveal its use by riverside populations as firewood, charcoal, and flooring, among other uses. Other research showed that the pracaxi tree has the potential to produce cellulose for papermaking [ 5 , 9 , 48 , 51 , 57 ]; however, its greatest potential lies in the seeds from which the oil, with all its medicinal properties, is extracted [ 5 , 7 , 10 , 12 , 14 , 21 , 25 , 33 , 54 ].…”

Section: Taxonomy Occurrence and Botanymentioning

confidence: 99%

“…The silicone base with pracaxi oil was named Pracasil ® Plus marketed by the Professional Compounding Centers of America-PCCA [ 22 ]. Another case study conducted by Simmons et al [ 21 ], in a 61-year-old male patient, with type 2 diabetes, who had an ulcer on the inner part of the leg and was treated with Pracasil ® Plus, after using Mupirocin for sixty years. Complete wound closure was observed in three days.…”

Section: Pharmacology and Biological Activitymentioning

confidence: 99%

“…Studies found in the literature show evidence regarding its therapeutic activity in wound healing and burns [ 21 , 22 , 23 ], antimicrobial activity [ 10 , 24 , 25 ], non-cytotoxicity, genotoxicity and expression in eukaryotic cells [ 26 , 27 ], atherogenicity and thrombogenicity index [ 28 , 29 ]. Results also show its effect as an insecticide against larvae of the Aedes aegypti mosquito, vector of dengue and yellow fever, and Helicorverpa zea [ 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Pentaclethra macroloba: A Review of the Biological, Pharmacological, Phytochemical, Cosmetic, Nutritional and Biofuel Potential of this Amazonian Plant

Lamarão

Ferreira

Lynch

et al. 2023

Plants

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Pracaxi (Penthaclethra macroloba (Willd.) Kuntze) is an Amazonian plant, traditionally used by the native population to treat health disorders such as inflammation, erysipelas, wound healing, muscle pain, ear pain, diarrhea, snake and insect bites as well as for cancer treatment. Other common uses include using the oil for frying, skin and hair beautification, and as an alternative source of energy. This review is focused on highlighting its taxonomy, occurrence and botanical origins, popular uses, pharmacology and biological activities, cytotoxicity, biofuel activity and phytochemistry in order to explore future therapeutic use and other applications. Pracaxi contains triterpene saponins, sterols, tannins, oleanolic acid, unsaturated fatty acids and long-chain fatty acids, with a high behenic acid value, which may serve for incorporation into drug delivery systems as well for the development of new drugs. These components are correlated with its anti-inflammatory, antimicrobial, healing, anti-hemolytic, anti-hemorrhagic, antiophidic, and larvicidal activities against Aedes aegypti and Helicorverpa zea, which ratify the popular/traditional uses. The species is nitrogen fixing; it is easy to propagate in floodplains and the terra firma, and it can be used for the reforestation of degraded areas. Additionally, the oil extracted from the seeds can leverage the bioeconomy of the region based on sustainable exploration.

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“…The trunk bark of P. macroloba has terpenoid saponins that have anti-hemorrhagic action against the venom of Bothrops vipers (da Silva et al, 2007). The main product used from P. macroloba is the oil extracted from the seeds, considered a potent herbal medicine for the healing of diabetic ulcers (Simmons et al, 2015), wounds, and burns (Banov et al, 2014). There are also reports of traditional use to treat snake bites, muscle pain, and wounds caused by leishmaniasis (Sarquis et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Demographic and growth patterns of Pentaclethra macroloba (Willd.) Kuntze, a hyperdominant tree in the Amazon River estuary

et al. 2022

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Little is known about the life history and environmental factors that regulate the growth rate of hyperdominant trees in flooded Amazonian forests. Pentaclethra macroloba is a hyperdominant tree, and it is widely explored in the Amazon, because its seed oil is a powerful herbal medicine. We evaluated the demographic structure and growth patterns of P. macroloba and tested the effect of the Amazon River flood pulse on its growth. We modeled the growth and determined the age of P. macroloba by analyzing the growth rings of 30 monitored trees in relation to hydroclimatic variables. We also inventoried 240 juvenile and 2072 adult trees arranged in a clustered pattern. The diametric distribution pattern of the juvenile and adult trees was exponential and log‐normal, respectively. The trees were found to be up to 102 years old, and 47% of them grew freely toward the canopy. Peak growth in height and diameter occurred at 24 (61.7 cm year‐1) and 46 (9.38 mm year‐1) years, respectively. Pentaclethra macroloba showed cambial dormancy during the seasonal peak of rainfall (R2 = 0.41; t = −2.62; p < 0.01) and flooding of the Amazon River (R2 = 0.47; t = −3.01; p < 0.01). Increases in rainfall and flood level of the river in the rainy season control the growth rate of P. macroloba, making it a seasonal process. The demographic and growth patterns of P. macroloba respond to the environmental heterogeneity of the estuarine floodplain forest and also reflect its life history over time.

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Use of a topical anhydrous silicone base containing fatty acids from pracaxi oil in a patient with a diabetic ulcer

Cited by 8 publications

References 11 publications

Complications Associated with Diabetes: A Case Study

Complications Associated with Diabetes: A Case Study

Pentaclethra macroloba: A Review of the Biological, Pharmacological, Phytochemical, Cosmetic, Nutritional and Biofuel Potential of this Amazonian Plant

Demographic and growth patterns of Pentaclethra macroloba (Willd.) Kuntze, a hyperdominant tree in the Amazon River estuary

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