2000
DOI: 10.1001/archderm.136.6.779
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Why a Skin Biopsy?

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Cited by 12 publications
(6 citation statements)
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“…6,7 Zhou et al 8 demonstrated in a retrospective study that the decision to treat did not depend on skin biopsy findings, that the decision to treat depended on clinical severity, and that the biopsy findings correlated poorly with the clinical severity, as a result concluding that skin biopsy plays a limited role. Even complex decision tree analysis has revealed that in populations in which the prevalence of aGVHD is greater than 30%, such as BMT services, the best outcomes are attained when no skin biopsy is performed and the patients are simply treated for aGVHD.…”
Section: Discussionmentioning
confidence: 99%
“…6,7 Zhou et al 8 demonstrated in a retrospective study that the decision to treat did not depend on skin biopsy findings, that the decision to treat depended on clinical severity, and that the biopsy findings correlated poorly with the clinical severity, as a result concluding that skin biopsy plays a limited role. Even complex decision tree analysis has revealed that in populations in which the prevalence of aGVHD is greater than 30%, such as BMT services, the best outcomes are attained when no skin biopsy is performed and the patients are simply treated for aGVHD.…”
Section: Discussionmentioning
confidence: 99%
“…Neither skin specimen showed the morphologic pattern of acute or chronic GVHD, as there were no vacuolizations, acantholyzes, basal edema, or increased lymphocytic infiltrates in the peripheral dermis or epidermis (24,25).…”
Section: Diagnosticsmentioning
confidence: 99%
“…It also remains the gold standard investigation, however, a number of variables impact the interpretation of skin biopsies [1]. Skin biopsies are performed most often either to arrive at a conclusive diagnosis or to evaluate the response to therapy [2]. Additionally, the biopsies may be performed for medicolegal reasons to confirm clinical suspicion.…”
Section: Introductionmentioning
confidence: 99%