Clinicopathological Concordance in 2216 Cases of Skin Biopsy over One Year: An Indian Experience

Malik, Akanksha; Siraj, Fouzia; Sharma, Swati; Gupta, Pooja; Khullar, Geeti; Ramesh, V.

doi:10.7759/cureus.7752

Cited by 6 publications

(13 citation statements)

References 13 publications

(27 reference statements)

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“…11,13 In present study, the subtype of leprosy with maximum concordance was BT-hansen's followed by LL-hansen's , similar findings were recorded by Malik et al and Manandhar et al while Balasubramaniam et al and Bhatia et al found maximum concordance in LL-hansen's followed by BT-hansen's. 11,13,14,15 Clinicohistopathological concordance for the fungal granulomas was (83.33%) which was higher in comparison to 76.46% of Dutta et al, direct microscopy was positive in 2 cases of chromoblastomycosis, and one case of candida and eumycetoma while in our study one case of zygomycosis and one case of mucormycosis showed nonseptate broad based hyphae. 8 One case of chromoblastomycosis showed pigmented sclerotic bodies also called Medlar bodies.…”

Section: Discussionsupporting

confidence: 89%

“…8 In a study by Malik et al out of total 2216 biopsies 555 were of granulomatous disease, which were divided into Hansen' disease, tubercular and non-infectious granulomas, showed a concordance of 51.3%, 70.77% and 40% respectively. 11 In our study, clinicopathological correlation in hansen's disease is 79.59%, which is higher than that in Malik et al and Balasubramanian et al (58.8%). 11,13 In present study, the subtype of leprosy with maximum concordance was BT-hansen's followed by LL-hansen's , similar findings were recorded by Malik et al and Manandhar et al while Balasubramaniam et al and Bhatia et al found maximum concordance in LL-hansen's followed by BT-hansen's.…”

Section: Discussioncontrasting

confidence: 64%

“…Cases of cutaneous tuberculosis showed concordance of 55.5% compared to 70.77% in Malik et al and 91.6% in Dutta et al 11,8 Tuberculoid granuloma was found in 9 (5.81%) cases and clinical pattern matched with studies from across the country where lupus vulgaris was the commonest type followed by scrofuloderma and tuberculosis verrucosa cutis. 8 In our study, one patient diagnosed histologically as foreign body granuloma, presenting with asymptomatic erythemaous plaque over the left breast since 2 month.…”

Section: Discussionsupporting

confidence: 55%

“…Aslan et al found the concordance of 76.8% in 3949 skin biopsies while Malik et al found the same to be 61.01%. 10,11 In a study conducted by Gupta et al in 282 cases concordance was 85.8% and in Balasubramanian et al it was 59.8%. 12,13 In a study conducted by Dutta et al a total of 300 cases of cutaneous granulomatous disorder were recorded, 83.39% showed clinicopathological concordance.…”

Section: Discussionmentioning

confidence: 93%

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Clinicopathological correlation in the diagnosis of granulomatous cutaneous disorders: a retrospective study

et al. 2021

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Background: To ascertain the various cutaneous granulomatous disorders and clinicopathological concordance in skin biopsies.Methods: The study included the patients with skin biopsy showing granulomatous infiltrate in a tertiary care center. The cases were categorized according to level of concordance into consistent, corroborative and inconsistent based on the concurrence between clinical and histological diagnosis.Results: Of the total 155 granulomatous disorder, 75.48% showed clinicopathological concordance, 19.35% showed corroborative diagnosis while 5.16% were inconsistent. The maximum number of biopsies performed were in the group of young adult (19-49 years, 57.41%). The most common type of granuloma found was of tuberculoid type and disorders were Hansen’s disease, fungal infection and cutaneous tuberculosis.Conclusions: Our study showed that the coordination of dermatologist and pathologist plays a pivotal role in making accurate diagnosis of granulomatous cutaneous dermatoses.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 64%

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 93%

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Clinicopathological correlation in the diagnosis of granulomatous cutaneous disorders: a retrospective study

et al. 2021

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“…13 Malik et al found 61.01% clinicopathological concordance. 14 They also concluded that the clinical photograph of the patient helps in better correlation at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

The Histopathological Spectrum and Clinico-Pathological Concordance in 85 Cases of Skin Biopsy: A Single Center Experience

Jha

Pokharel

2021

Nepal J Dermatol Venereol & Leprol

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Introduction Skin disease is common in developing countries but the spectrum varies widely. Skin biopsy is an important tool in confirming or establishing diagnoses in cases with diagnostic dilemmas. And, there may be a discrepancy between clinical and pathological diagnoses. Objective To determine the spectrum of histological diagnoses in skin disease and to know the consistency between clinical and pathological diagnoses. Materials and methods A retrospective review of histological and clinical diagnoses was done at a multi-specialty hospital. A total of 85 cases were included in the study. Clinical and histological data along with demographic details, the site of the biopsy was noted. Concordance between clinical and pathological diagnosis was determined as concordant, partially concordant and discordant. Results There were 60% female and 40% male patients out of 85 biopsies. The most common age group was 31-40 years and the mean age was 41.24 years. The most common histological spectrum was infectious group in 29.4%, followed by papulosquamous disorders in 22.4% and eczema in 12.9% cases. The concordance between clinical and pathological diagnosis was 60%, while partial concordance was seen in 16.5% and discordance was seen in 23.5% cases. Conclusion Skin biopsy is an important tool in confirming clinical diagnoses. There is a wide variation of histological diagnoses and concordance with clinical diagnoses may be increased with proper clinical history, physical findings and differential diagnosis.

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Clinico-Histopathological Consistency in Dermatological Diseases

et al. 2021

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Skin biopsy for histopathology is the most reliable investigation for diagnosis of skin diseases. The main purpose of skin biopsy is to confirm clinical diagnosis but dermatologists usually looking for the concordance with histopathological report. The aim of the study was to observe the consistency of clinical and histopathological diagnosis of skin diseases. An observational study was conducted on 630 patients that undertaken skin biopsy and that was performed at the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University from January 2018 to January 2019. Patients who were advised for biopsy by outpatient and inpatient department and the biopsy was done accordingly was included in the study. Finally the inclusion was confirmed when the histopathological report was available. Demographic information, clinical diagnosis, type of biopsy procedure, types of specimen taken and send for histopathological procedure and the histopathological diagnosis was noted in data collection sheet. Histopathological diagnosis and its correlation with clinical diagnosis was assessed for consistency and it was the main outcome measure of the study. The mean age of patients on whom biopsy was performed was 35.14 ±16.57 years and the age range was 5-82 years. Male patients outnumbered female and the male to female ratio was 1.15: 1. Three types of biopsy were performed among them incisional biopsy was the commonest type (93.5%). In most of the cases collected specimen was skin 94.76%, others type of specimens were mucous membrane 2.6%, nail matrix 1.9% and 0.6% specimen was hair follicle. Among the cases 71.43% was diagnosed clinically. The common clinical diagnosis in which biopsy was done was psoriasis and its types 17.77%, lichen planus and its variants 14.12%, the connective tissue diseases 6.19% and infectious diseases 5.39%. In 79.52% cases histopathological diagnosis was done and 68.22% diagnosis was consistent with the clinical diagnosis. The maximum clinico-pathological concordance was found in vesiculo-bullous disease 93.33%. Then connective tissue diseases 79.48%, vasculitides 75% and lichenoid diseases 73.56%. Skin biopsy is a conclusive tool to overcome diagnostic dilemmas in dermatological diseases. The clinico-pathological concordance is assumed lower than the expectation of dermatologists but the collective efforts of dermatologists and pathologists can improve the capacity of diagnosis of biopsy samples. Bangladesh Med J. 2020 Sept; 49(3) : 29-34

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Clinicopathological Concordance in 2216 Cases of Skin Biopsy over One Year: An Indian Experience

Cited by 6 publications

References 13 publications

Clinicopathological correlation in the diagnosis of granulomatous cutaneous disorders: a retrospective study

Clinicopathological correlation in the diagnosis of granulomatous cutaneous disorders: a retrospective study

The Histopathological Spectrum and Clinico-Pathological Concordance in 85 Cases of Skin Biopsy: A Single Center Experience

Clinico-Histopathological Consistency in Dermatological Diseases

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