Whole Salivary Interleukin‐6 and Matrix Metalloproteinase‐8 Levels in Patients With Chronic Periodontitis With and Without Prediabetes

Javed, Fawad; Ahmed, Hameeda Bashir; Anwar, Saeed; Mehmood, Abid; Bain, Crawford

doi:10.1902/jop.2013.130514

Cited by 43 publications

(39 citation statements)

References 29 publications

(53 reference statements)

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“…It is well known that periodontal inflammatory conditions are worse in patients with systemic conditions such as chronic hyperglycemia than in medically healthy individuals. [41][42][43] In all studies included in the present review 9,15-18,27-33 patients with systemic disorders were excluded. Therefore, the outcome of periodontal therapy (with and without diode laser application) is expected to be compromised in patients with chronic systemic diseases such as diabetes.…”

Section: Discussionmentioning

confidence: 99%

Role of Diode Lasers (800–980 Nm) as Adjuncts to Scaling and Root Planing in the Treatment of Chronic Periodontitis: A Systematic Review

Qadri

Javed

Johannsen

et al. 2015

Photomedicine and Laser Surgery

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Section: Discussionmentioning

confidence: 99%

Role of Diode Lasers (800–980 Nm) as Adjuncts to Scaling and Root Planing in the Treatment of Chronic Periodontitis: A Systematic Review

Qadri

Javed

Johannsen

et al. 2015

Photomedicine and Laser Surgery

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“…The concentrations of MMP-8, MMP-9, and MMP-13 in saliva are higher in subjects with generalized periodontitis than in the corresponding controls. Recently, Javed et al [28] showed that salivary IL-6 and MMP-8 levels are elevated in patients with chronic periodontitis with and without prediabetes.…”

Section: Discussionmentioning

confidence: 99%

Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

Gupta

Gupta²,

Khan

et al. 2014

Front. Med.

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Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases (MMPs) secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups: group I consisted of 20 periodontally healthy subjects (controls) while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth (PPD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI). Around 3ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA (Windows version 6) software. Salivary MMP-8 levels of groups I and II were 190.91 ± 143.89 ng/ml and 348.26 ± 202.1 ng/ml, respectively. The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and significant correlations (for PPD, r = 0.63, P < 0.001; for CAL, r = 0.54, P < 0.001; for GI, r = 0.49, P < 0.001; and for PI, r = 0.63, P < 0.001). The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.

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“…They were then instructed to expectorate the saliva into a funnel connected to a gauged measuring cylinder. The amount of saliva expectorated was recorded in milliliters (19)(20)(21)). The UWS samples were then transferred to plastic tubes with a lid and stored at −70°C.…”

Section: Peri-implant Clinical and Radiographic Parametersmentioning

confidence: 99%

Peri-implant clinical and radiographic status and whole salivary cotinine levels among cigarette and waterpipe smokers and never-smokers

et al. 2018

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The aim was to compare the peri-implantclinical and radiographic inflammatory parameters and whole salivary cotinine levels among cigarette smokers (CS), waterpipe smokers (WS) and neversmokers (NS). Thirty-four CS (Group 1), 33 WS (Group 2), and 31 NS (Group 3) were included. Peri-implant plaque index (PI), bleeding-on-probing (BOP), and probing depth (PD) were measured, and crestal bone loss (CBL) was assessed on standardized digital radiographs. Unstimulated whole saliva samples were collected and whole salivary cotinine levels were measured. Peri-implant PI and PD were higher in Groups 1 (P < 0.05) and 2 (P < 0.05) than in Group 3. Peri-implant BOP was significantly higher in Group 3 than in Groups 1 (P < 0.01) and 2 (P < 0.01). Peri-implant MBL was significantly higher in Groups 1 (P < 0.05) and 2 (P < 0.05) than in Group 3. There were significant differences in PI, BOP, PD, and CBL between Groups 1 and 2. There was no significant difference in the whole salivary cotinine levels in Groups 1 and 2. Peri-implant sites with plaque accumulation, PD, CBL, and whole salivary cotinine levels were higher in CS and WS than in NS, but did not differ between CS and WS.

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Whole Salivary Interleukin‐6 and Matrix Metalloproteinase‐8 Levels in Patients With Chronic Periodontitis With and Without Prediabetes

Abstract: Salivary IL-6 and MMP-8 levels are elevated in patients with CP with and without prediabetes.

Cited by 43 publications

References 29 publications

Role of Diode Lasers (800–980 Nm) as Adjuncts to Scaling and Root Planing in the Treatment of Chronic Periodontitis: A Systematic Review

Role of Diode Lasers (800–980 Nm) as Adjuncts to Scaling and Root Planing in the Treatment of Chronic Periodontitis: A Systematic Review

Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

Peri-implant clinical and radiographic status and whole salivary cotinine levels among cigarette and waterpipe smokers and never-smokers

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