White Bean seeds and Pomegranate peel and fruit seeds as hypercholesterolemic and hypolipidemic agents in albino rats

Abstract

RESUMEN Semillas de alubias blancas y piel y semillas de granadas como agentes hipercolesterolémicos e hipolipidémicos en ratas albinasSe ha llevado a cabo un estudio para evaluar los efectos de las semillas de alubias blancas y de las de granadas así como de sus cáscaras secas y sus mezclas sobre los perfiles de lípidos de ratas que sufren de hiperlipidemia e hipercolesterolemia. La composición química de las alubias blancas y de las granadas (semillas y cáscaras) fue determinada en base a materia seca alcanzando una buena relación de proteí-nas, lípidos, fibra cruda y fenoles. Además, el contenido de fenoles de las semillas y las cáscaras de granada mostraron 16 compuestos que varían en cantidad entre ellos. Se observó que la catequina y los fenoles son los compuestos predominantes. Los resultados obtenidos mostraron un buen poder hipolipidémico de las semillas de alubias blancas y de granadas (semillas y las cáscaras), así como sus mezcla. Las semillas de alubias blancas en la dieta produjo una mejora general de la situación clínica, del perfil de lípidos en sangre (lípidos totales, triglicéridos, colesterol, HDL-C, LDL-C y VLDL-c), de la función hepática (ALT, AST y bilirrubina), de la función de los riñones (ácido úrico, urea y creatinina), de la peroxidación de lípidos en sangre y de las enzimas antioxidantes (SOD y CAT) por lo que se reduce la hiperlipidemia e hipercolesterolemia. La dieta mezcla presentó la mayor influencia sobre los estudios biológicos en relación con los otros tratamientos que utilizan solamente semillas de alubias blancas o granadas (semillas y cáscaras). PALABRAS CLAVE: Alubia blanca (Phaseolus vulga ris L.) -Granada (Punica granatum) -Hipocolesterolemia -Hipolipidemia. ABSTRACT White Bean seeds and Pomegranate peel and fruit seeds as hypercholesterolemic and hypolipidemic agents in albino ratsThis study was carried out to evaluate the effects of soaked white bean seeds, pomegranate seeds and dried peels and their mixtures on the lipid profiles of rats suffering from hyperlipidemia and hypercholesterolemia. The chemical compositions of dried soaked beans and pomegranate (seeds and peels) were determined on dry matter which amounted to good values for proteins, lipids, crude fiber and phenols. Also, the phenol contents of pomegranate seeds and peels showed 16 compounds varying in amount between them. It was noticed that catechin and phenol are the dominating compounds.The obtained results showed a good hypolipidemic ability for soaked bean seeds and pomegranate (seeds, peels and their mixtures) as well as their mixtures. A bean seeds diet produced a general improvement in the clinical status of blood lipid profile (total lipids, triglycerides, cholesterol, HDL-c, LDL-c and VLDL-c), liver function (ALT, AST and bilirubin), kidneys function (uric acid, urea and creatinine), blood lipid peroxidation and antioxidant enzymes (SOD and CAT) by which hyperlipidemia and hypercholesterolemia were reduced. The mixed diet had the best influence concerning biological studies than the other treatme...

Pomegranate (Punica granatum L.) peel hydro alcoholic extract ameliorates cardiovascular risk factors in obese women with dyslipidemia: A double blind, randomized, placebo controlled pilot study

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Physicochemical and Organoleptic Characteristics of Cakes Supplemented With Tomato Pomace, Mango Seeds Kernel and Pomegranate Peels Powders

“…Pomegranate peel, a by-product of juice processing industries was reported to contain high phenolic compounds in addition to its properties as good source of crude fiber and inorganic residues that embrace wide health primitive features like prevention from the development of cardiovascular disorders, anti-inflammatory, hypoglycemic, apoptotic, anti-parasitic and as prebiotic (Abdel-Rahim et al, 2013). Supplementation of bakery products like cake, which are very popular among children and are a rich source of energy and protein, with tomato pomace powders, mango seeds kernel powder, and pomegranate peels powder will further help in improving the nutritional and chemical qualities of developed cake (Tharshini et al, 2018).…”

The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD)

“…It could be dysfunction endothelial or vasodilatation, which caused damage to endothelial cells. 24 But, at that histopathology, representation didn't show endothelial dysfunction clearly.…”