Which physical and structural factors of liposome carriers control their drug-loading efficiency?

Kępczyński, Mariusz; Nawalany, Kinga; Kumorek, Marta; Kobierska, Agnieszka; Jachimska, Barbara; Nowakowska, Maria

doi:10.1016/j.chemphyslip.2008.05.174

Cited by 52 publications

(41 citation statements)

References 34 publications

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“…Incorporation of cholesterol proved to reduce the partitioning of porphyrins, while methyl oleate and PEGylated lipids noticeably increased the value of the relevant binding constants [77]. Another important feature deriving from lipid modification is the insertion of functional groups able to bind ligands to the surface of liposomes.…”

Section: Nanocarriersmentioning

confidence: 99%

Targeted Delivery of Protein Drugs by Nanocarriers

2010

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Recent advances in biotechnology demonstrate that peptides and proteins are the basis of a new generation of drugs. However, the transportation of protein drugs in the body is limited by their high molecular weight, which prevents the crossing of tissue barriers, and by their short lifetime due to immuno response and enzymatic degradation. Moreover, the ability to selectively deliver drugs to target organs, tissues or cells is a major challenge in the treatment of several human diseases, including cancer. Indeed, targeted delivery can be much more efficient than systemic application, while improving bioavailability and limiting undesirable side effects. This review describes how the use of targeted nanocarriers such as nanoparticles and liposomes can improve the pharmacokinetic properties of protein drugs, thus increasing their safety and maximizing the therapeutic effect.

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Section: Nanocarriersmentioning

confidence: 99%

Targeted Delivery of Protein Drugs by Nanocarriers

2010

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“…Rodrigues et al 8 reported that the electrostatic-hydrophobic interactions across biological membranes played an important role in drug absorption and therapeutic effects. Kepczynski et al 9 studied the correlation between structural and physical properties of lipid membrane and its drug-loading efficiency, and found that the free volume rather than hydrophobicity of bilayer was a governing factor in the solute partitioning into lipid bilayers. Therefore, it is meaningful to study the interaction between drug and liposomes and the impacts of drug on the properties of liposomes.…”

Section: Introductionmentioning

confidence: 99%

Interaction between (1,1′‐Binaphthalene)‐2,2′‐diol and Lecithin Liposome

Chen¹,

Gan²,

An³

et al. 2010

Chin. J. Chem.

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The interaction between (1,1'-binaphthalene)-2,2'-diol (BINOL) and lecithin liposome was studied by UV-Vis, fluorescence and 1 H NMR spectroscopies. BINOL can obviously associate with lecithin liposome and the preferential binding site of BINOL with lecithin liposome is located in the headgroup region. The hydrogen bond and electrostatic interaction should exist in BINOL/liposome system, which restricts intra-annular rotation of naphthol moieties. Therefore, the fluorescence intensity of BINOL increases when a small quantity of liposome is added into the system. The partition coefficient K D between the lecithin liposome and the aqueous phase is 310.9. With the increase of BINOL concentration, the micropolarity (I 1 /I 3 ) and membrane fluidity of liposome decreased, while the viscosity of membrane increased.

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“…Moreover, the method of active loading is only applicable to amphiphilic drugs; and other types of agents, hydrophilic and lipophilic ones, cannot be remotely loaded into liposomes. Although, up to now, a variety of other methods have been developed for the preparation of liposomes, but few methods can be conveniently used to prepare acceptable liposomal drugs (Barenholz, 2003;Fanciullino and Ciccolini, 2009;Kepczynski et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Preparation of submicron liposomes exhibiting efficient entrapment of drugs by freeze-drying water-in-oil emulsions

Wang

et al. 2011

Chemistry and Physics of Lipids

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Which physical and structural factors of liposome carriers control their drug-loading efficiency?

Cited by 52 publications

References 34 publications

Targeted Delivery of Protein Drugs by Nanocarriers

Targeted Delivery of Protein Drugs by Nanocarriers

Interaction between (1,1′‐Binaphthalene)‐2,2′‐diol and Lecithin Liposome

Preparation of submicron liposomes exhibiting efficient entrapment of drugs by freeze-drying water-in-oil emulsions

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