Interaction between (1,1′‐Binaphthalene)‐2,2′‐diol and Lecithin Liposome

Abstract

The interaction between (1,1'-binaphthalene)-2,2'-diol (BINOL) and lecithin liposome was studied by UV-Vis, fluorescence and 1 H NMR spectroscopies. BINOL can obviously associate with lecithin liposome and the preferential binding site of BINOL with lecithin liposome is located in the headgroup region. The hydrogen bond and electrostatic interaction should exist in BINOL/liposome system, which restricts intra-annular rotation of naphthol moieties. Therefore, the fluorescence intensity of BINOL increases when a small quantity of liposome is added into the system. The partition coefficient K D between the lecithin liposome and the aqueous phase is 310.9. With the increase of BINOL concentration, the micropolarity (I 1 /I 3 ) and membrane fluidity of liposome decreased, while the viscosity of membrane increased.

Experimental and theoretical NMR studies of interaction between phenylalanine derivative and egg yolk lecithin

“…NMR technique as a very powerful analytical method has been applied to study structural and dynamic properties of phospholipid liposomes and interactions between various compounds and lipid membranes . For example, numerous 1 H NMR investigations on reverse micellar systems aimed at determination of the nature of phospholipid–water interactions were reported .…”