Preparation of submicron liposomes exhibiting efficient entrapment of drugs by freeze-drying water-in-oil emulsions

Wang, Ting; Wang, Ning; Wang, Tongyan; Sun, Weiran; Li, Tiefu

doi:10.1016/j.chemphyslip.2010.12.005

Cited by 35 publications

(15 citation statements)

References 31 publications

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“…6 A further report by Zvonar et al described use of a self-microemulsifying system to fabricate Ca-pectinate microcapsules to improve the release and permeability of furosemide. 7 Drug-loaded polymer microspheres have been variously prepared by phase separation, 8 interfacial polymerization, 9 spray-drying, 10 freeze-drying, 11 and emulsion evaporation. 12 However, these conventional strategies always either involve an intense operating process or preparation of particles with a wide particle size distribution and a relatively large amount of organic solvent residue.…”

Section: Introductionmentioning

confidence: 99%

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Chen¹,

Wang²,

Wang³

et al. 2012

IJN

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Background:The aim of this study was to improve the drug loading, encapsulation efficiency, and sustained-release properties of supercritical CO 2 -based drug-loaded polymer carriers via a process of suspension-enhanced dispersion by supercritical CO 2 (SpEDS), which is an advanced version of solution-enhanced dispersion by supercritical CO 2 (SEDS). Methods: Methotrexate nanoparticles were successfully microencapsulated into poly (L-lactide)-poly(ethylene glycol)-poly(L-lactide) (PLLA-PEG-PLLA) by SpEDS. Methotrexate nanoparticles were first prepared by SEDS, then suspended in PLLA-PEG-PLLA solution, and finally microencapsulated into PLLA-PEG-PLLA via SpEDS, where an "injector" was utilized in the suspension delivery system. Results: After microencapsulation, the composite methotrexate (MTX)-PLLA-PEG-PLLA microspheres obtained had a mean particle size of 545 nm, drug loading of 13.7%, and an encapsulation efficiency of 39.2%. After an initial burst release, with around 65% of the total methotrexate being released in the first 3 hours, the MTX-PLLA-PEG-PLLA microspheres released methotrexate in a sustained manner, with 85% of the total methotrexate dose released within 23 hours and nearly 100% within 144 hours. Conclusion: Compared with a parallel study of the coprecipitation process, microencapsulation using SpEDS offered greater potential to manufacture drug-loaded polymer microspheres for a drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Chen¹,

Wang²,

Wang³

et al. 2012

IJN

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“…Extensively studied examples are ultrasound sonication, proposed for liposomal encapsulation of anticancer drugs [232], extrusion reduced polydispersity and size of niosomes loaded with tretinoin [233] or high-pressure homogenization with a uniform dispersion of SUVs containing the poorly soluble drug fenofibrate [234]. The most novel technologies are based on compressed fluids (CFs) [214,235], microfluidics [211,232] and freezedrying of emulsions [236]. In compressed fluid technology (CFs), the gas is rapidly pressurized, which modulates the solvent density and solubilization power.…”

Section: Non-liposomal Nanovesiclesmentioning

confidence: 99%

“…The mentioned emulsion is freeze-dried and the solid pellet is resuspended, prior to its use. Several small molecule drugs, including hydrophobic (e. g. flurbiprofen), hydrophilic (e. g. paeoniflorin) and amphiphilic (e. g. barberin) APIs, were encorporated into liposomal SUVs [236].…”

Section: Non-liposomal Nanovesiclesmentioning

confidence: 99%

Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot

Milcovich

Lettieri

Antunes

et al. 2017

Advances in Colloid and Interface Science

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Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self-assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications. In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.

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“…[38][39][40][41] Also it is argued that when used as a vaccine carrier liposomes fulfil a dual function of delivery and adjuvanticity, although the latter is rather weak. 42 Thus, to increase the adjuvanticity, antigen-loading capacity as well as delivery efficiency, conventional liposomes are often modified on surface or in membranes with functional materials, such as the ionizable lipidic ingredients, TLR ligands, and C-type receptor-binding molecules, engendering the multifunctional liposomes to act as a carrier that can efficiently capture the oppositely charged antigens and targetedly deliver the immunogenic agents to APCs.…”

Section: Multifunctional Liposomes Constituted Mpmasmentioning

confidence: 99%

Multifunctional particle-constituted microneedle arrays as cutaneous or mucosal vaccine adjuvant-delivery systems

Wang

et al. 2016

Human Vaccines & Immunotherapeutics

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To overcome drawbacks of current injection vaccines, such as causing needle phobia, needing health professionals for inoculation, and generating dangerous sharps wastes, researchers have designed novel vaccines that are combined with various microneedle arrays (MAs), in particular, with the multifunctional particle-constructed MAs (MPMAs). MPMAs prove able to enhance vaccine stability through incorporating vaccine ingredients in the carrier, and can be painlessly inoculated by minimally trained workers or by selfadministration, leaving behind no metal needle pollution while eliciting robust systemic and mucosal immunity to antigens, thanks to delivering vaccines to cutaneous or mucosal compartments enriched in professional antigen-presenting cells (APCs). Especially, MPMAs can be easily integrated with functional molecules fulfilling targeting vaccine delivery or controlling immune response toward a Th1 or Th2 pathway to generate desired immunity against pathogens. Herein, we introduce the latest research and development of various MPMAs which are a novel but promising vaccine adjuvant delivery system (VADS).

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Preparation of submicron liposomes exhibiting efficient entrapment of drugs by freeze-drying water-in-oil emulsions

Cited by 35 publications

References 31 publications

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot

Multifunctional particle-constituted microneedle arrays as cutaneous or mucosal vaccine adjuvant-delivery systems

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