Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Chen, Ai-Zheng; Wang, Guangya; Wang, Shibin; Li, Li; Liu, Yuangang; Zhao, Chunxiao

doi:10.2147/ijn.s32662

Cited by 25 publications

(12 citation statements)

References 36 publications

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“…The modified SAS processes include aerosol solvent extraction system, 15 supercritical anti-solvent with enhanced mass transfer, 31 supercritical fluid-assisted extraction of emulsions, 41 and solution-enhanced dispersion by supercritical fluids (SEDS). [28][29][30] Among all these SAS processes available, SEDS is the most advanced anti-solvent process for particle precipitation. In this review, we provide a comprehensive overview of this process based on the literature published in the past two decades related to drug delivery through various routes of administration.…”

Section: Sas Processmentioning

confidence: 99%

“…SpEDS is one of the most advanced processes that have been developed for broadening the application of SEDS and overcoming its processing damage issues. 29 The device setup of this process is almost similar to SEDS, but SpEDS has an auxiliary injector equipped with a piston to efficiently pump the loaded suspension of the drug or the drug-polymer mixture ( Figure 1). 29,30 The use of injector setup in this process is highly advantageous as it avoids obstruction of the one-way valve and damage of the high-pressure pump during pumping of the particle suspension into the high-pressure vessel.…”

Section: Suspension-enhanced Dispersion By Supercritical Fluidsmentioning

confidence: 99%

“…29 The device setup of this process is almost similar to SEDS, but SpEDS has an auxiliary injector equipped with a piston to efficiently pump the loaded suspension of the drug or the drug-polymer mixture ( Figure 1). 29,30 The use of injector setup in this process is highly advantageous as it avoids obstruction of the one-way valve and damage of the high-pressure pump during pumping of the particle suspension into the high-pressure vessel. 29,66,67 This process predominantly results in core-shell structured drug-polymer composites at an arbitrary size ranging from microscale to nanoscale with high drug encapsulation efficiency.…”

Section: Suspension-enhanced Dispersion By Supercritical Fluidsmentioning

confidence: 99%

“…This technology is perhaps one of the rapidly evolving processes with many variants since its first report in 1879. 22 Different variants of the SCF technology for particle fabrication are categorized based on the behavior of SCF, such as "solvent" (rapid expansion of supercritical solutions), 23 "solute" (particle formation from gas-saturated solutions), 24 "anti-solvent" (supercritical anti-solvent [SAS], 25 and its variants 15,[26][27][28][29][30][31] ), "reagent", 32 and others such as supercritical-assisted atomization process 10,33,34 and depressurization of an expanded liquid organic solution. 15,35 Despite the variance in the behavior, SCF acts as a re-precipitation aid for rapid, uniform, as well as smooth nucleation of solutes (drug and/ or polymer) in all the above-mentioned processes intended for particle fabrication.…”

Section: Introductionmentioning

confidence: 99%

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Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Kankala¹,

Chen²,

Liu³

et al. 2018

IJN

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In recent years, the supercritical fluid (SCF) technology has attracted enormous interest from researchers over the traditional pharmaceutical manufacturing strategies due to the environmentally benign nature and economically promising character of SCFs. Among all the SCF-assisted processes for particle formation, the solution-enhanced dispersion by supercritical fluids (SEDS) process is perhaps one of the most efficient methods to fabricate the biomaterials and pharmaceutical compounds at an arbitrary gauge, ranging from micro- to nanoscale. The resultant miniature-sized particles from the SEDS process offer enhanced features concerning their physical attributes such as bioavailability enhancement due to their high surface area. First, we provide a brief description of SCFs and their behavior as an anti-solvent in SCF-assisted processing. Then, we aim to give a brief overview of the SEDS process as well as its modified prototypes, highlighting the pros and cons of the particular modification. We then emphasize the effects of various processing constraints such as temperature, pressure, SCF as well as organic solvents (if used) and their flow rates, and the concentration of drug/polymer, among others, on particle formation with respect to the particle size distribution, precipitation yield, and morphologic attributes. Next, we aim to systematically discuss the application of the SEDS technique in producing therapeutic nano-sized formulations by operating the drugs alone or in combination with the biodegradable polymers for the application focusing oral, pulmonary, and transdermal as well as implantable delivery with a set of examples. We finally summarize with perspectives.

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Section: Sas Processmentioning

confidence: 99%

Section: Suspension-enhanced Dispersion By Supercritical Fluidsmentioning

confidence: 99%

Section: Suspension-enhanced Dispersion By Supercritical Fluidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Kankala¹,

Chen²,

Liu³

et al. 2018

IJN

Self Cite

View full text Add to dashboard Cite

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“…[29][30][31] Suspension-enhanced dispersion by supercritical CO 2 (SpEDS) has been used in our lab to prepare composite microparticles, since it can effectively reduce the residual solvent and control the particle distribution under mild conditions. 32,33 Methotrexate (MTX) is an antifolate class of antineoplastic agent which is used for the treatment of psoriasis and rheumatoid arthritis at low doses, and leukemia at high doses. [34][35][36] The systemic use of this drug causes numerous side effects, such as hepatic toxicity, thrombocytopenia, anemia, fatigue, and so on.…”

Section: Introductionmentioning

confidence: 99%

Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery

Chen¹,

Chen²,

Wang³

et al. 2015

IJN

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A synergistic approach by the combination of magnetic nanoparticles with an alternating magnetic field for transdermal drug delivery was investigated. Methotrexate-loaded silk fibroin magnetic nanoparticles were prepared using suspension-enhanced dispersion by supercritical CO 2 . The physiochemical properties of the magnetic nanoparticles were characterized. In vitro studies on drug permeation across skin were performed under different magnetic fields in comparison with passive diffusion. The permeation flux enhancement factor was found to increase under a stationary magnetic field, while an alternating magnetic field enhanced drug permeation more effectively; the combination of stationary and alternating magnetic fields, which has a massage-like effect on the skin, achieved the best result. The mechanistic studies using attenuated total reflection Fourier-transform infrared spectroscopy demonstrate that an alternating magnetic field can change the ordered structure of the stratum corneum lipid bilayers from the gel to the lipid-crystalline state, which can increase the fluidity of the stratum corneum lipids, thus enhancing skin penetration. Compared with the other groups, the fluorescence signal with a bigger area detected in deeper regions of the skin also reveals that the simulated massage could enhance the drug permeation across the skin by increasing the follicular transport. The combination of magnetic nanoparticles with stationary/alternating magnetic fields has potential for effective massage-like transdermal drug delivery.

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Highly Stretchable Piezoelectric Elastomer for Accelerated Repairing of Skeletal Muscles Loss

Fang,

Wang,

Lin

et al. 2024

Adv Funct Materials

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Skeletal muscle loss is a common clinical disease, whose long treatment period and expensive treatment costs bring a heavy burden to patients. Currently, the use of piezoelectric materials to generate in situ and efficient electrical stimulation has been proven to significantly promote wound healing and other defects. However, skeletal muscle requires repaired materials with high elastic deformation to accompany its reciprocating movement during the healing process. Therefore, developing biocompatible materials that combine high piezoelectricity and stretchability is a great challenge. In the present work, a piezoelectric elastomer PPBE is prepared by copolymerization of bio‐based diacid and diol. PPBE has matching elastic modulus with the skeletal muscle to accompanied proceed stretching and recovery movements. Piezoelectrical charge from PPBE scaffold under ultrasound and mechanical stimuli could promote myogenic differentiation via Ca2+ signaling pathway and modulate cell functions, resulting in improved muscle morphology and functional performance of skeletal muscle. Thus, development of the degradable PPBE scaffold would provide new therapy strategy for volumetric muscle loss (VML) and present great potential in repairing of other tissues.

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Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Cited by 25 publications

References 36 publications

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery

Highly Stretchable Piezoelectric Elastomer for Accelerated Repairing of Skeletal Muscles Loss

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