Which is more effective for protein adsorption: surface roughness, surface wettability or swelling? Case study of polyurethane films prepared from castor oil and poly(ethylene glycol)

Akkaş, Tuğba; Citak, Cansu; Sirkecioğlu, Ahmet; Güner, F. Seniha

doi:10.1002/pi.4408

Cited by 67 publications

(54 citation statements)

References 29 publications

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“…All samples exhibit characteristic polyurethane peaks in their FTIR spectra (Figure ). As mentioned in experimental part, the absence of the absorbance at around 2265 cm −1 for the final product indicated consuming of isocyanates and formation of polyurethane . The disappearance of the absorption peak at 3464 cm −1 , assigned to the hydroxyl group, confirmed that all hydroxyl groups were consumed in the reaction.…”

Section: Resultsmentioning

confidence: 53%

Castor oil and PEG‐based shape memory polyurethane films for biomedical applications

Bonfil

Sirkecioğlu

Bingöl-Ozakpinar

et al. 2014

J of Applied Polymer Sci

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A series of polyurethane film were prepared from poly(ethylene glycol) with different molecular weight (PEG 1500, 3000, and 8000) and castor oil by one‐shot bulk polymerization method. Hexamethylene diisocyanate and 1,4‐buthane diol were used as diisocyanate and chain extender, respectively. In order to characterize the samples, their density, swelling ratio, water contact angle, surface free energy, gel content, thermal, and viscoelastic properties were determined. The effect of the soft segment length (SSL) and hard segment content (HSC) of all polyurethane films on their shape memory behavior such as shape fixity (Rf) and shape recovery (Rr) rates were investigated by bending test. Direct contact and MTT tests were used for assessment of cell adhesion and proliferation. The relatively high Rf and Rr values were obtained for the samples programmed at high temperature difference. Rf increased with decreasing HSC. On the other hand, Rr tended to decrease with increasing SSL. After evaluating experimental data by a nonlinear equation, it was found that HSC is more effective parameter on shape memory property than SSL. The gel content, swelling ratio, and water contact angle of the samples were dependent on both SSL and HSC in their structures. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40590.

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Section: Resultsmentioning

confidence: 53%

Castor oil and PEG‐based shape memory polyurethane films for biomedical applications

Bonfil

Sirkecioğlu

Bingöl-Ozakpinar

et al. 2014

J of Applied Polymer Sci

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“…19 Roughness of surfaces also play a critical role in adhesion of proteins. 21, 22 It has been found to be an important factor at the nanometer scale for both fibrinogen and bovine serum albumin attachment. 21 Increasing random roughness increases the adhesion of proteins to surfaces of biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Enhanced antibacterial efficacy of nitric oxide releasing thermoplastic polyurethanes with antifouling hydrophilic topcoats

et al. 2017

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Surface fouling is one of the leading causes of infection associated with implants, stents, catheters, and other medical devices. The surface chemistry of medical device coatings is important in controlling and/or preventing fouling. In this study, we have shown that a combination of nitric oxide releasing hydrophobic polymer with a hydrophilic polymer topcoat can significantly reduce protein attachment and subsequently reduce bacterial adhesion as a result of the synergistic effect. Nitric oxide (NO) is a well-known potent antibacterial agent due to its adverse reactions on microbial cell components. Owing to the surface chemistry of hydrophilic polymers, they are suitable as antifouling topcoats. In this study, four biomedical grade polymers were compared for protein adhesion and NO-release behavior: CarboSil 2080A, RTV, SP60D60, and SG80A. SP60D60 was found to resist protein adsorption up to 80% when compared to the other polymers while CarboSil 2080A maintained a steady NO flux even after 24 hours (~0.50 × 10−10 mol cm−2 min−1) of soaking in buffer solution with a loss of less than 3 wt% S-nitroso-N-acetylpenicillamine (SNAP), the NO donor molecule, in the leaching analysis. Therefore, CarboSil 2080A incorporated with SNAP and topcoated with SP60D60, was tested for antibacterial efficacy after exposure to fibrinogen, an abundantly found protein in blood. The NO-releasing CarboSil 2080A with SP60D60 topcoated polymer showed a 96% reduction in Staphylococcus aureus viable cell count compared to the control samples. Hence, the study demonstrated that a hydrophilic polymer topcoat, when applied to a polymer with sustained NO release from underlying SNAP incorporated hydrophobic polymer, can reduce bacterial adhesion and be used as a highly efficient antifouling, antibacterial polymer for biomedical applications.

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“…Surface roughness and surface physicochemical properties (among them wettability) of the biomaterial are interrelated with the protein adsorption phenomenon. 9,10,11 The water adsorption to the implant surface depends on the charge density of the surface which is strongly influenced by its nanoscale roughness. 12,13 These factors have the major contribution in defining the implant surface-to-blood interactions as well as influencing the cell adhesion and, consequently, their growth and differentiation.…”

Section: Introductionmentioning

confidence: 99%

Wettability studies of topologically distinct titanium surfaces

Kulkarni

Patil-Sen

Junkar

et al. 2015

Colloids and Surfaces B: Biointerfaces

117

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The contact area of the water droplet on hydrophobic titanium planar surface (foil) was found to decrease during evaporation, whereas the contact area of the droplet on hydrophobic nanorough titanium surfaces practically remained unaffected until the complete evaporation.This demonstrates that the surface morphology and roughness at the nanoscale level substantially affect the titanium dioxide surface-water droplet interaction, opposing to previous observations for microscale structured surfaces. The difference in surface topographic nanofeatures of nanostructured titanium surfaces could be correlated not only with the time-dependency of the contact area, but also with time-dependency of the contact angle and electrochemical properties of these surfaces.

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Which is more effective for protein adsorption: surface roughness, surface wettability or swelling? Case study of polyurethane films prepared from castor oil and poly(ethylene glycol)

Cited by 67 publications

References 29 publications

Castor oil and PEG‐based shape memory polyurethane films for biomedical applications

Castor oil and PEG‐based shape memory polyurethane films for biomedical applications

Enhanced antibacterial efficacy of nitric oxide releasing thermoplastic polyurethanes with antifouling hydrophilic topcoats

Wettability studies of topologically distinct titanium surfaces

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