Where Is the Drug? Quantitative 3D Distribution Analyses of Confined Drug-Loaded Polymer Matrices

Abstract

To enhance oral bioavailability of poorly soluble drugs, microfabricated devices can be utilized.

Volumetric Raman chemical imaging of drug delivery systems

“…A minor amount of crystalline drug was observed outside the MCs (Figure b). It is important to notice that we were not able to distinguish crystalline naproxen in our previous work due to incomplete methodology of dVRi. In particular, fluorescence impact (see Figure b) was not taken into account.…”

“…The universality of the developed method for highly sensitive volumetric Raman chemical imaging of fluorescent and highly absorptive samples was tested on several drugs and MCs with different dimensions in our previous study. [29] As an example, the distribution of naproxen loaded into the polymer matrix is shown on Figure 4b (Movie S3). In this case, naproxen was concentrated on the top of the MCs, with limited penetration into the PVP matrix.…”

“…This result was achieved by the development of a confocal Raman microscope with high Raman signal throughput, optimization of sample mapping method, and further chemometric hyperspectral data analysis based on nonnegative least squares (NNLS) . Preliminary experimental results were shown in our previous study . Here, we present a detailed description of the optical and analytical solutions implemented in the dVRI method.…”

“…[3] Preliminary experimental results were shown in our previous study. [29] Here, we present a detailed description of the optical and analytical solutions implemented in the dVRI method.…”

How Molecular Mobility, Physical State, and Drug Distribution Influence the Naproxen Release Profile from Different Mesoporous Silica Matrices

“…20,22,23 The synthetized matrices have similar pore sizes (∼3 nm) and naproxen loading percentages (∼30% w/w) in the composites, allowing to evaluate the impact of their disordered/ordered network, guest−host interaction, and the way how the guest is distributed among the host network. Indeed, the drug distribution is also an important parameter governing drug release as demonstrated for naproxen and ketoprofen loaded in confined polymer matrices (see ref 24 and references therein).…”