Microdevices to successfully deliver orally administered drugs

Mazzoni, Chiara; Nielsen, Line Hagner

doi:10.1016/b978-0-12-818038-9.00012-0

Cited by 6 publications

(5 citation statements)

References 110 publications

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“…Microdevices are mostly designed for therapeutic drug delivery in the gastrointestinal tract, but the devices may also be suitable for carrying probiotics. They usually include micropatches, microwells, or microcontainers in the size range of 100-300 µm, typically in a square or spherical shape [63]. Non-biodegradable and biodegradable materials, e.g., polylactic acid can also be applied as vehicles of microdevices; however, their use for this purpose is under testing.…”

Section: Strategies For Improved Oral Deliverymentioning

confidence: 99%

Scientific and Pharmaceutical Aspects of Christensenella minuta, a Promising Next-Generation Probiotic

Pető,

Kósa,

Szilvássy

et al. 2023

Fermentation

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Christensenella minuta (C. minuta), a member of a recently described bacterial family, is one of the most heritable next-generation probiotics. Many observational studies confirmed that the relative abundance of C. minuta is associated with lean body types with a low host body mass index (BMI), and is also influenced by age, diet, and genetics. By utilizing its benefits, it could be suited to many therapies, including human and animal health as well. However, a reliable method for culturing the strain must also be developed to enable the therapeutic administration of the microbe. Sludge microfiltration could be a promising solution for large scale-up cultivation. In this review, different processing methods are also described from pharmaceutical aspects.

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Section: Strategies For Improved Oral Deliverymentioning

confidence: 99%

Scientific and Pharmaceutical Aspects of Christensenella minuta, a Promising Next-Generation Probiotic

Pető,

Kósa,

Szilvássy

et al. 2023

Fermentation

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“…Compared to other lithographic techniques, soft lithography is more advantageous as it can overcome several limitations inherent to photolithography, such as high cost, time consumption, and resolution 8 . Furthermore, microdevices can be fabricated by utilizing soft lithography without the need for laborious photolithographic steps or clean rooms 55 . Although soft lithography is more capable for industrial applications, this technique can also be practical for micropatterning complex molecules because of flexible PDMS, as it can potentially form tight bonds with substrates 29 .…”

Section: Microfabrication Techniquesmentioning

confidence: 99%

“…8 Furthermore, microdevices can be fabricated by utilizing soft lithography without the need for laborious photolithographic steps or clean rooms. 55 Although soft lithography is more capable for industrial applications, this technique can also be practical for micropatterning complex molecules because of flexible PDMS, as it can potentially form tight bonds with substrates. 29 Subsequently, such a feature allows for more reliable replication of patterning.…”

Section: Soft Lithographymentioning

confidence: 99%

Advances in microfabrication technologies in tissue engineering and regenerative medicine

et al. 2022

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Background Tissue engineering provides various strategies to fabricate an appropriate microenvironment to support the repair and regeneration of lost or damaged tissues. In this matter, several technologies have been implemented to construct close‐to‐native three‐dimensional structures at numerous physiological scales, which are essential to confer the functional characteristics of living tissues. Methods In this article, we review a variety of microfabrication technologies that are currently utilized for several tissue engineering applications, such as soft lithography, microneedles, templated and self‐assembly of microstructures, microfluidics, fiber spinning, and bioprinting. Results These technologies have considerably helped us to precisely manipulate cells or cellular constructs for the fabrication of biomimetic tissues and organs. Although currently available tissues still lack some crucial functionalities, including vascular networks, innervation, and lymphatic system, microfabrication strategies are being proposed to overcome these issues. Moreover, the microfabrication techniques that have progressed to the preclinical stage are also discussed. Conclusions This article aims to highlight the advantages and drawbacks of each technique and areas of further research for a more comprehensive and evolving understanding of microfabrication techniques in terms of tissue engineering and regenerative medicine applications.

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“…MCs have also been employed as efficient vaccine, antibiotic, and probiotic carriers. [19][20][21] In contrast to passive MCs, MMs can autonomously propel themselves in certain environments and perform various functions leading to delivery of pharmaceutical compounds, [22] degradation of nitroaromatic explosives [23] and organic pollutants, [24] protein disaggregation, [25] photothermal therapy, [26] pH sensing, [27] vapor sensing, [28] and warfare agent removal. [29] The dynamic behavior allows MMs to become more readily engulfed in mucus and biofilms.…”

Section: Introductionmentioning

confidence: 99%

“…At the same time, the Mg-Au-Para-MMs release from the MC's and start their own self-motion. This dual MC-MM motion might be an additional Small 2023,19, 2206330…”

mentioning

confidence: 99%

Microscopic Cascading Devices for Boosting Mucus Penetration in Oral Drug Delivery—Micromotors Nesting Inside Microcontainers

Marić

Adamakis

Zhang

et al. 2023

Small

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In the case of macromolecules and poorly permeable drugs, oral drug delivery features low bioavailability and low absorption across the intestinal wall. Intestinal absorption can be improved if the drug formulation could be transported close to the epithelium. To achieve this, a cascade delivery device comprising Magnesium‐based Janus micromotors (MMs) nesting inside a microscale containers (MCs) has been conceptualized. The device aims at facilitating targeted drug delivery mediated by MMs that can lodge inside the intestinal mucosa. Loading MMs into MCs can potentially enhance drug absorption through increased proximity and unidirectional release. The MMs will be provided with optimal conditions for ejection into any residual mucus layer that the MCs have not penetrated. MMS confined inside MCs propel faster in the mucus environment as compared to non‐confined MMs. Upon contact with a suitable fuel, the MM‐loaded MC itself can also move. An in vitro study shows fast release profiles and linear motion properties in porcine intestinal mucus compared to more complex motion in aqueous media. The concept of dual‐acting cascade devices holds great potential in applications where proximity to epithelium and deep mucus penetration are needed.

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Microdevices to successfully deliver orally administered drugs

Cited by 6 publications

References 110 publications

Scientific and Pharmaceutical Aspects of Christensenella minuta, a Promising Next-Generation Probiotic

Scientific and Pharmaceutical Aspects of Christensenella minuta, a Promising Next-Generation Probiotic

Advances in microfabrication technologies in tissue engineering and regenerative medicine

Microscopic Cascading Devices for Boosting Mucus Penetration in Oral Drug Delivery—Micromotors Nesting Inside Microcontainers

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