What people know about congenital CMV: an analysis of a large heterogeneous population through a web-based survey

Binda, Sandro; Pellegrinelli, Laura; Terraneo, Marco; Caserini, Alessandra; Prímache, V.; Bubba, Laura; Barbi, Maria

doi:10.1186/s12879-016-1861-z

Cited by 30 publications

(44 citation statements)

References 24 publications

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“…They examined knowledge, attitudes, screening and the use of antivirals in affected infants. The conclusion that improved recognition of congenital CMV is necessary reflects an increasing body of published work that comes to similar conclusions in the Netherlands , in the USA , in France , in Singapore and published most recently in a larger (10 190 subjects) Italian population . The recurrent message, including as outlined by Gunkel et al., is that knowledge of congenital CMV is very low amongst specialist obstetricians and paediatricians, primary physicians, parents and the general public.…”

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confidence: 77%

“…Of course, this varies between different measured parameters. In parallel with these studies, surveys (again using CAWI) of pregnant women and university staff suggest lower levels of knowledge about congenital CMV in the nonhealthcare worker population. Again this varies between populations, being higher in tertiary educated individuals than nontertiary educated individuals, lower in pregnant women (up to 39% in some populations) and varying between countries.…”

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confidence: 82%

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Congenital CMV international guidelines are needed to guide diagnosis, prevention and management

Rawlinson

2017

Acta Paediatr

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confidence: 77%

mentioning

confidence: 82%

Congenital CMV international guidelines are needed to guide diagnosis, prevention and management

Rawlinson

2017

Acta Paediatr

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“…Almost 90% of students were unable to identify any clinical material that could be a source of a virus or activity associated with the risk of CMV infection. For comparison, in a study conducted among 10,190 students (69.2%) and academic and administrative staff (30.8%) at the University of Milan [22], more than a half of the respondents (52.5%) had heard about cytomegalovirus, and 31.8% of them knew that it could cause congenital infection. In this group, only 16% of the respondents were unable to indicate any routes of virus transmission, and the remaining group of persons indicated saliva (67.9%), blood (67.6%), sexual contacts (58.4%), transfusion/transplant (53.0%), urine (42.7%) and breast milk (42.2%) as sources of infection.…”

Section: Discussionmentioning

confidence: 99%

Awareness of congenital cytomegalovirus infection among young people studying non-medical subjects

Trzcińska¹,

Cześcik²,

Siennicka³

2019

Med Og Nauk Zdr.

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Introduction.Congenital infections are still a serious public health problem. They may be related, among others, to the lack of immunization against many pathogens that would reduce the number of cases of infection among pregnant women. In this situation, educational activities are important, disseminating knowledge about available prophylaxis. Objective. Aim of the study is to assess the state of knowledge of young people studying in fields not related to medical care, about congenital infections, mainly congenital CMV infection. Materials and method. The study was conducted by a questionnaire survey. The study group consisted of 225 students aged 20-29 (99 women and 126 men). The questions concerned, among others: knowledge of diseasees/infections affecting the foetus/child; sources and activities related to the risk of CMV infection; hygiene behaviours that can help prevent CMV infection. Results. Down syndrome (88%) and autism (80.9%) belonged to the most frequently reported diseases that may affect children. Knowledge of congenital infections, in addition to congenital toxoplasmosis (28.9%), was below 10%. Knowledge of the fact that CMV infection can be transmitted from mother to foetus was confirmed by 16/225 respondents. Only 8.9% of the respondents knew at least one hygienic behaviour that could contribute to a reduction in the number of CMV infections, and over 91% did not indicate any such behaviour. Conclusion. The survey conducted among students revealed that knowledge about congenital infections possessed by potential parents is not satisfactory. The study clearly indicated the need to undertake educational activities. StreszczenieWprowadzenie. Zakażenia wrodzone nadal stanowią poważny problem zdrowia publicznego. Może to być związane m.in. z faktem, iż w przypadku wielu patogenów brakuje możliwości immunizacji, która pozwoliłaby na ograniczenie liczby przypadków zakażeń wśród kobiet ciężarnych. W takiej sytuacji duże znaczenie mają działania edukacyjne, szerzące wiedzę na temat dostępnej profilaktyki. Cel pracy. Ocena wiedzy młodzieży studiującej na kierunkach niezwiązanych z opieką medyczną na temat zakażeń wrodzonych, głównie zakażenia wrodzonego CMV. Materiały i metody. Badanie miało charakter badania ankietowego. Grupę badaną stanowiło 225 studentów w wieku od 20 do 29 lat (99 kobiet oraz 126 mężczyzn). Pytania dotyczyły m.in.: znajomości jednostek chorobowych/ zakażeń i zarażeń dotykających płód/dziecko; źródeł zakażenia i czynności związanych z ryzykiem zakażenia CMV; zachowań higienicznych, które mogą pomagać w zapobieganiu zakażeniu CMV. Wyniki. Do najczęściej wskazywanych jednostek chorobowych, które mogą dotykać płód/dziecko należały zespół Downa (88%) i autyzm (80,9%). Znajomość zakażeń wrodzonych, poza wrodzoną toksoplazmozą (28,9%), kształtowała się na poziomie poniżej 10%. Fakt, że zakażenie CMV może być przenoszone z matki do płodu był znany 16 spośród 225 ankietowanych. Tylko 8,9% ankietowanych znało przynajmniej jedno zachowanie higieniczne, które może przyczyniać się do ograniczeni...

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“…The most important application of DBS testing is the retrospective diagnosis of congenital Cytomegalovirus (cCMV) infection; since CMV is the most common cause of sensorineural hearing loss (SNHL), CMV diagnosis should be recommended when children fail newborn hearing screening and should be carried out within the first weeks of life [3]. Although cCMV infection is the most common congenital infection, few people are aware of this infection and how to control or prevent it [4]. However, although DBS is a promising method for collecting microliters of blood samples, there are still some limitations.…”

Section: Introductionmentioning

confidence: 99%

Diagnosing congenital Cytomegalovirus infection: don’t get rid of dried blood spots

et al. 2020

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Background: Congenital Cytomegalovirus (cCMV) is a serious global public health issue that can cause irreversible fetal and neonatal congenital defects in symptomatic or asymptomatic newborns at birth. In absence of universal cCMV screening, the retrospective diagnosis of cCMV infection in children is only possible by examining Dried Blood Spot (DBS) samples routinely collected at birth and stored for different time spans depending on the newborn screening regulations in force in different countries. In this article, we summarize the arguments in favor of long-term DBS sample storage for detecting cCMV infection. Main text: CMV infection is the most common cause of congenital infection resulting in severe defects and anomalies that can be apparent at birth or develop in early childhood. Sensorineural hearing loss is the most frequent consequence of cCMV infection and may have a late onset and progress in the first years of life. The virological diagnosis of cCMV is essential for clinical research and public health practices. In fact, in order to assess the natural history of CMV infection and distinguish between congenital or acquired infection, children should be diagnosed early by analyzing biological samples collected in the first weeks of life (3 weeks by using viral culture and 2 weeks by molecular assays), which, unfortunately, are not always available for asymptomatic or mildly symptomatic children. It now seems possible to overcome this problem since the CMV-DNA present in the blood of congenitally infected newborns can be easily retrieved from the DBS samples on the Guthrie cards routinely collected and stored within 3 days from birth in the neonatal screening program for genetic and congenital diseases. Early collection and long-term storage are inexpensive methods for long-term bio-banking and are the key points of DBS testing for the detection of cCMV. Conclusion: DBS sampling is a reliable and inexpensive method for long-term bio-banking, which enables to diagnose known infectious diseases-including cCMV-as well as diseases not jet recognized, therefore their storage sites and long-term storage conditions and durations should be the subject of political decision-making.

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What people know about congenital CMV: an analysis of a large heterogeneous population through a web-based survey

Cited by 30 publications

References 24 publications

Congenital CMV international guidelines are needed to guide diagnosis, prevention and management

Congenital CMV international guidelines are needed to guide diagnosis, prevention and management

Awareness of congenital cytomegalovirus infection among young people studying non-medical subjects

Diagnosing congenital Cytomegalovirus infection: don’t get rid of dried blood spots

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