What is the role of admission <scp>HbA1c</scp> in managing <scp>COVID</scp>‐19 patients?

Sathish, Thirunavukkarasu; Cao, Yingting

doi:10.1111/1753-0407.13140

Cited by 18 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there are some studies that have shown that higher levels of HbA1c are associated with disease progression and mortality, while few studies have not. [6][7][8][9] These results highlight the relevant role of diabetes treatment regimen and glycemic control prior to COVID-19 infection and their association with poor outcomes. In Mexico, the COVID-19 pandemic has resulted in increased mortality rates due to the high burden of cardiometabolic diseases, which facilitate the development of severe COVID-19.…”

mentioning

confidence: 81%

Impact of undiagnosed type 2 diabetes and pre-diabetes on severity and mortality for SARS-CoV-2 infection

Vargas‐Vázquez

Bello‐Chavolla

Ortíz-Brizuela

et al. 2021

BMJ Open Diab Res Care

View full text Add to dashboard Cite

IntroductionDiabetes and hyperglycemia are risk factors for critical COVID-19 outcomes; however, the impact of pre-diabetes and previously unidentified cases of diabetes remains undefined. Here, we profiled hospitalized patients with undiagnosed type 2 diabetes and pre-diabetes to evaluate its impact on adverse COVID-19 outcomes. We also explored the role of de novo and intrahospital hyperglycemia in mediating critical COVID-19 outcomes.Research design and methodsProspective cohort of 317 hospitalized COVID-19 cases from a Mexico City reference center. Type 2 diabetes was defined as previous diagnosis or treatment with diabetes medication, undiagnosed diabetes and pre-diabetes using glycosylated hemoglobin (HbA1c) American Diabetes Association (ADA) criteria and de novo or intrahospital hyperglycemia as fasting plasma glucose (FPG) ≥140 mg/dL. Logistic and Cox proportional regression models were used to model risk for COVID-19 outcomes.ResultsOverall, 159 cases (50.2%) had type 2 diabetes and 125 had pre-diabetes (39.4%), while 31.4% of patients with type 2 diabetes were previously undiagnosed. Among 20.0% of pre-diabetes cases and 6.1% of normal-range HbA1c had de novo hyperglycemia. FPG was the better predictor for critical COVID-19 compared with HbA1c. Undiagnosed type 2 diabetes (OR: 5.76, 95% CI 1.46 to 27.11) and pre-diabetes (OR: 4.15, 95% CI 1.29 to 16.75) conferred increased risk of severe COVID-19. De novo/intrahospital hyperglycemia predicted critical COVID-19 outcomes independent of diabetes status.ConclusionsUndiagnosed type 2 diabetes, pre-diabetes and de novo hyperglycemia are risk factors for critical COVID-19. HbA1c must be measured early to adequately assess individual risk considering the large rates of undiagnosed type 2 diabetes in Mexico.

show abstract

mentioning

confidence: 81%

Impact of undiagnosed type 2 diabetes and pre-diabetes on severity and mortality for SARS-CoV-2 infection

Vargas‐Vázquez

Bello‐Chavolla

Ortíz-Brizuela

et al. 2021

BMJ Open Diab Res Care

View full text Add to dashboard Cite

show abstract

“…However, none of our patients with newly diagnosed diabetes progressed to severe illness or died, probably because of the mild infection. Nevertheless, COVID-19 patients with newly diagnosed diabetes, particularly those with marked hyperglycemia, should be followed-up for the emergence of full-blown diabetes and other cardiometabolic disorders [ 5 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Newly diagnosed diabetes in patients with mild to moderate COVID-19

Sathish

Anton

2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

Self Cite

View full text Add to dashboard Cite

Background and aims We aimed to study newly diagnosed diabetes in patients with mild to moderate COVID-19. Methods This is a retrospective cohort study of COVID-19 patients who were admitted to a tertiary care hospital in India from May to October 2020. Results Of 102 patients, 21 (20.6%) had newly diagnosed diabetes on admission. Of which, four (19.0%) had marked hyperglycemia with no ketosis or ketoacidosis. Conclusion In this study of patients with mild to moderate COVID-19, newly diagnosed diabetes and marked hyperglycemia in those with newly diagnosed diabetes were common.

show abstract

“…In conclusion, our study suggests that people with prediabetes are at high risk for severe illness and mortality from COVID-19. All COVID-19 patients should be screened with HbA1c on admission [ 19 ] so that those with prediabetes can be identified for close monitoring and early initiation of appropriate treatment to improve their prognosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and outcomes of COVID-19 patients with prediabetes

Chandrasekaran

Rao

Sathish

2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

Self Cite

View full text Add to dashboard Cite

Background and aims We aimed to examine the clinical characteristics and outcomes of coronavirus disease 2019 (COVID-19) patients with prediabetes. Methods This was a retrospective cohort study of 102 COVID-19 patients admitted to a tertiary care hospital in India between May and October 2020. Results Most patients had a poor clinical profile on admission. They had high rates of invasive mechanical ventilation (48%), intensive care unit admission (48%), complications (72.6%), and mortality (32.4%). Conclusion People with prediabetes are at high risk for poor outcomes from COVID-19.

show abstract

What is the role of admission HbA1c in managing COVID‐19 patients?

Cited by 18 publications

References 20 publications

Impact of undiagnosed type 2 diabetes and pre-diabetes on severity and mortality for SARS-CoV-2 infection

Impact of undiagnosed type 2 diabetes and pre-diabetes on severity and mortality for SARS-CoV-2 infection

Newly diagnosed diabetes in patients with mild to moderate COVID-19

Clinical characteristics and outcomes of COVID-19 patients with prediabetes

Contact Info

Product

Resources

About