Background and aims We aimed to study newly diagnosed diabetes in patients with mild to moderate COVID-19. Methods This is a retrospective cohort study of COVID-19 patients who were admitted to a tertiary care hospital in India from May to October 2020. Results Of 102 patients, 21 (20.6%) had newly diagnosed diabetes on admission. Of which, four (19.0%) had marked hyperglycemia with no ketosis or ketoacidosis. Conclusion In this study of patients with mild to moderate COVID-19, newly diagnosed diabetes and marked hyperglycemia in those with newly diagnosed diabetes were common.

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Introduction: Diabetes mellitus, a chronic metabolic disease affects various organs of the body on a long-term basis. Studies have been conducted on different aspects of the disease, to understand its complications and to detect them earlier to avoid irreversible damage like nephropathy. Aim: The study aims at comparing platelet indices like Plateletcrit (PCT), Platelet Distribution Width (PDW) and Mean Platelet Volume (MPV), with serum creatinine among diabetes, prediabetes patients and non-diabetes controls, to understand the association of the platelet indices and creatinine, an indicator of renal damage. Materials and Methods: The cross-sectional study conducted over a period of three months involved 30 non-diabetic controls with normal HbA1c, 30 diabetics and 30 prediabetic subjects, of age group 18-35 years. The groups were classified based on their HbA1c concentration. The blood samples were analyzed for parameters PCT, PDW, MPV, creatinine and HbA1c by their respective methods. The study will guide in understanding the role of platelets in pathogenesis of diabetic nephropathy. Results: Platelet indices like Plateletcrit (PCT), Platelet Distribution Width (PDW) and Mean Platelet Volume (MPV) were found to be increased in diabetics and 30 prediabetic subjects than the non-diabetics. The Platelet indices were also correlating with the serum creatinine levels of the three study groups. Conclusion: There is a positive association between the Platelet indices and creatinine, in patients with pre-diabetes and diabetes who have the risk of progression to diabetic nephropathy. Hence, the Platelet indices shall be included as early and cost-effective biomarkers of diabetic nephropathy.

A bstract Introduction The measured D-dimer levels in coronavirus disease-2019 (COVID-19) patients have no specific cutoff to find the progression of coagulopathy and severity. Aim This study aimed to determine prognostic cutoff values of D-dimer for intensive care unit (ICU) admission among COVID-19 patients. Materials and methods This cross-sectional study was conducted in Sree Balaji Medical College and Hospital, Chennai, during a period of 6 months. This study included 460 COVID-19-positive individuals. Results The mean age was 52.2 ± 12.53 years. Patients with mild illness have D-dimer value 461.8 ± 221, whereas moderate and severe COVID illness patients have D-dimer values of 1915.2 ± 699.9 and 7937.6 ± 2045.2, respectively. D-dimer cutoff value of 1036.9 is shown to be a prognostic cutoff value for COVID-19 patients admitted in the ICU with 99% sensitivity and 17% specificity. The area under curve (AUC) was considered excellent (AUC = 0.827, 95% Cl: 0.78–0.86, p -value < 0.0001) indicative of high sensitivity. Conclusion The D-dimer value of 1036.9 ng/mL was found to be the optimum cutoff for the patients to predict the severity of the COVID-19-positive patients admitted in the ICU. How to cite this article Anton MC, Shanthi B, Vasudevan E. Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients. Indian J Crit Care Med 2023;27(2):135–138.

: Low grade inflammation is one of the causes in the pathogenesis of type 2 diabetes. Interleukin – 6 (IL-6) a proinflammatory cytokine is found to be increased in type 2 diabetic patients. This study was aimed to assess the role of Interleukin -6 in type 2 diabetes mellitus. This was a cross sectional study done among diabetics and non- diabetics. The total number of subjects involved in the study was 120 within the age group of 20-50 years attending the outpatient department and diabetic clinic of Sree Balaji Medical College and Hospital. The study group comprised of Group- I – 40, age and sex matched non diabetic subjects. Group- II – 40, type II diabetic patients with good control of blood glucose, Group III – 40, type II diabetic patients with poor glycemic control. Blood samples were taken after 8 hours of fasting period, centrifuged at 3000 rpm for 10 min and serum, plasma separated. Plasma glucose levels (FBG, PPBG) were estimated by GOD/POD method, IL- 6 levels were measured by ELISA method and HbA1c by immunoturbidimetric method. Data was statistically analyzed using the Statistical Package for the Social Sciences (SPSS) version 18. Results showed that the circulating Interleukin- 6 (IL-6) levels were found to be elevated in type 2 diabetics than non diabetic subjects (p < 0.0001). Raised level of Interleukin-6 was found in diabetics compared to non diabetics that showed the presence of inflammatory mechanisms in diabetes patients. Also uncontrolled diabetics have increased Interleukin-6 levels. In addition to periodic checking of HbA1c, it is paramount important to check the inflammatory status in high risk subjects for diabetes and also in diabetics to prevent diabetic complications.

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