People are the widely used mobile technology for their activities in various sectors. This technology also is widely considered for use in education; included in science learning. On the other hand, almost all people in many regions in Indonesia are connected through the internet network. However, the use of mobile technology for learning is still the islands around the Flores area. This study aims to determine how high school students respond after attending mobile learning. This research is a quantitative descriptive study with a sample of 58 students from three different schools at Sikka of East Nusa Tenggara in Indonesia. Students are involved in mobile learning in material physics within two weeks. Learning active ies include reading learning subjects, practicing questions, discussion in forums, posting ideas, quizzes, and final examinations. During this learning, the teacher used Edmodo, like a learning management system. Students filled the questionnaire measuring their response to the use of technology. The USE questionnaire was used to measure this response. The results of this study indicate that students in this region have the right level of acceptance of mobile learning. As a follow-up, it needs to be promoted by local government policies on schools for this mobile learning.