What are the Antioxidant Status Predictors’ Factors among Male Chronic Obstructive Pulmonary Disease (COPD) Patients?

Abstract

Imbalance between antioxidant and oxidative stress is a major risk factor for pathogenesis of some chronic diseases such as chronic obstructive pulmonary disease (COPD). This study aimed to determine antioxidant and oxidative stress status, and also theirs association with respiratory function of male COPD patients to find the antioxidant predictors’ factors. A total of 149 subjects were involved in a cross-sectional study. The study was conducted at two medical centers in Kuala Lumpur, Malaysia. Results of the study showed that plasma vitamin C was low in most of the subjects (86.6%). Total antioxidant capacity was the lowest in COPD stage IV compare to other stages (p < 0.05). Level of plasma vitamin A (p= 0.012) and vitamin C (p= 0.007) were low in malnourished subjects. The predictors for total antioxidant capacity were forced vital capacity (FVC) % predicted and intake of β-carotene (R2= 0.104, p= 0.002). Number of cigarette (pack/year) and smoking index (number/year) were not associated with total antioxidant capacity of this COPD population. Plasma oxidative stress as assessed plasma lipid peroxidation (LPO) was only positively correlated with plasma glutathione (p= 0.002). It might be a need to evaluate antioxidant status especially in older COPD patients to treat antioxidant deficiency which is leading to prevent COPD progression.

A study of oxidative stress, antioxidant status and TNF- and #945; in chronic obstructive pulmonary disease

“…However, the single best variable for predicting which adults will have airflow obstruction on the spirometry is a history of more than 40 pack-years of smoking. These findings are similar to those reported in a study conducted by Pirabbasi et al [9] The level of TNF- was found to be significant higher in cases (0.886  0.424; p <0.001) compared to age-and sex-matched healthy controls (0.111  0.059), which is similar to that reported in another study. Because it is a stable product, this is the reason why it is used as the marker of oxidative damage of unsaturated fatty acids.…”

Reliability and Usefulness of Different Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease

“…Various antioxidants elements have been measured in COPD by means of spectrophotometric or chromatographic methods: vitamin A, C, and E and αand β-carotenes that contribute to the antioxidant defense system; essential trace elements that play a role in oxidant/antioxidant pathways; and uric acid, a powerful antioxidant protecting lipoproteins from oxidation and acting as a scavenger of oxygen radicals. These biomarkers have especially been studied in the blood of patients with COPD, where a reduction or no difference was found compared to the healthy controls [15,17,18,20,30,34,46,47,62,72,92,94,96,110,123].…”

Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review

“…A decreased level of vitamin C [25, 28, 62] and E [25, 28, 30], as well as no difference in the levels of vitamin A [27], C [40, 48, 95] and E [27] has been described in COPD compared to healthy controls. No differences have also been found in the different stages of severity of disease [96]. A significant reduction of vitamins A, C and E has been described in exacerbated COPD, with a restoration to values similar to that of controls after exacerbation treatment [58].…”

“…Using the FRAP assay a significant decrease of total antioxidant capacity has been found in COPD patients compared to controls [29, 36] in relation also to disease progression [29, 36, 96]. …”