A study of oxidative stress, antioxidant status and TNF- and #945; in chronic obstructive pulmonary disease

Abstract

Background: Nearly all smokers show some evidence of lung and systemic cellular and/or humoral inflammation, only a few will experience an amplified response and develop chronic obstructive pulmonary disease (COPD). Several studies have shown systemic inflammation in COPD patients with increased neutrophil, macrophage and T lymphocyte numbers, and high concentrations of inflammatory mediators in peripheral blood (C-reactive protein, interleukin (IL)-6, IL-8, and tumor necrosis factor- (TNF-)). Aims and Objective: To study oxidative stress, antioxidant status, and TNF- levels in patients with COPD. Materials and Methods: Forty-four COPD patients along with an equal number of age-and sex-matched controls were included in study. The levels of malondialdehyde (MDA; by thiobarbituric acid assay), assay of TNF- (by TNF-), and total antioxidant were measured. Results: Malondialdehyde level was found to be significantly higher in all cases, and it was statistically significant in COPD patients with Global Initiative on Obstructive Lung Disease (GOLD) classification grades 2 and 3. Total antioxidant level was significantly lower in all the patients with COPD and was statistically significant in GOLD grades 2 and 3. Like MDA, TNF level was also significantly higher in all the cases with statistically significant increase in GOLD grades 2 and 3. Conclusion: To better understand the role of these trace elements and oxidative stress in the pathogenesis and complications of COPD, it is recommended to carry out further clinical studies.

Determination of Relationship Between Lipid Peroxidation, Antioxidant Defence, Trace Elements and Hemorheology in COPD

“…The results of our study in patients with COPD indicate that while lipid peroxidation takes place in the organism, and the members of the antioxidant processes could not be able to trigger the efficient defense systems. Despite the lipid peroxidation in the course of COPD, our results claiming the inadequacy of the antioxidant defense systems in the pathogenesis of COPD are confirmed by various investigators [19][20][21].…”