Reliability and Usefulness of Different Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease

Zinellu, Elisabetta; Zinellu, Angelo; Fois, Alessandro Giuseppe; Fois, Sara S.; Piras, Bastiana; Carru, Ciriaco; Pirina, Pietro

doi:10.1155/2020/4982324

Cited by 35 publications

(39 citation statements)

References 119 publications

(127 reference statements)

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“…In addition, COPD patients exhibit a systemic proinflammatory state characterized by an increase in circulating cytokines, chemokines, and acute-phase proteins [ 53 ]. Moreover, in these patients, the pro-oxidant mechanisms overcome the antioxidant defenses with consequent oxidative stress [ 12 , 54 ]. Albumin is a multifunctional plasma protein that is described to diminish in inflammatory conditions, and it is considered a negative acute-phase protein [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin Concentrations in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Zinellu¹,

Fois

Sotgiu

et al. 2021

JCM

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Background: Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by chronic airway inflammation and lung parenchyma damage. Systemic inflammation and oxidative stress also play a role in the pathogenesis of COPD. Serum albumin is a negative acute-phase protein with antioxidant effects and an important marker of malnutrition. The aim of this meta-analysis was to investigate differences in serum albumin concentrations between patients with stable COPD and non-COPD subjects. Methods: A systematic search was conducted, using the terms “albumin” and “chronic obstructive pulmonary disease” or “COPD”, in the electronic databases PubMed and Web of Science, from inception to May 2020. Results: Twenty-six studies were identified on a total of 2554 COPD patients and 2055 non-COPD controls. Pooled results showed that serum albumin concentrations were significantly lower in COPD patients (standard mean difference, SMD = −0.50, 95% CI −0.67 to −0.32; p < 0.001). No significant differences were observed in SMD of serum albumin concentrations between COPD patients with forced expiratory volume in the 1st second (FEV1) < 50% and those with FEV1 > 50%. Conclusions: Our systematic review and meta-analysis showed that serum albumin concentrations are significantly lower in patients with stable COPD compared to non-COPD controls. This supports the presence of a deficit in systemic anti-inflammatory and antioxidant defense mechanisms in COPD.

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Section: Discussionmentioning

confidence: 99%

Serum Albumin Concentrations in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Zinellu¹,

Fois

Sotgiu

et al. 2021

JCM

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“…In this study, we have also assessed oxidative stress biomarkers, more specifically 8-oxodG, 8-isoprostane and glutathione. Many biomarkers of oxidative stress have been investigated in respiratory diseases [12,13,30]. An imbalance between oxidant markers (reactive oxygen species and their oxidation target products) and various antioxidants have been found in asthma and COPD [13,30].…”

Section: Discussionmentioning

confidence: 99%

“…Many biomarkers of oxidative stress have been investigated in respiratory diseases [12,13,30]. An imbalance between oxidant markers (reactive oxygen species and their oxidation target products) and various antioxidants have been found in asthma and COPD [13,30]. A significant increase of serum glutathione in chronic bronchitis without airway obstruction compared to controls was found for the first time (hierarchical model).…”

Section: Discussionmentioning

confidence: 99%

“…As far as we know, there are no other case-control studies on glutathione levels in the blood of chronic bronchitis subjects. Many studies have evaluated GSH levels in COPD showing different results, and a reduction of GSH has been described in patients compared to controls [13], but few other studies have shown an increase in GSH levels. In particular, Ahmad et al found an increase of total blood glutathione in 140 patients with COPD compared to 70 controls, and highlighted a negative correlation of this marker with FEV 1 %, [31]; Nadeem et al also found higher levels of total blood glutathione in 82 patients with COPD compared to 22 healthy controls [32].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, 8-isoprostane, which is a product of lipid peroxidation and 8-oxo-7,8-dihydro-2 -deoxyguanosine (8-oxodG), a product of DNA oxidation. Among antioxidants we have examined glutathione that constitutes an important component of the antioxidant defense system and has been largely studied as a major oxidative stress biomarker [13]. Patients with CB have shown an increased OS with higher levels of malondialdehyde, a biomarker of lipid peroxidation and decreased levels of antioxidants, such as superoxide dismutase and glutathione, compared to a group of control subjects [12].…”

Section: Introductionmentioning

confidence: 99%

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Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases

Chamitava

Cazzoletti

Ferrari

et al. 2020

IJMS

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Introduction: The global burden of chronic airway diseases represents an important public health concern. The role of oxidative stress and inflammation in the pathogenesis of these diseases is well known. The aim of this study is to evaluate the behavior of both inflammatory and oxidative stress biomarkers in patients with chronic bronchitis, current asthma and past asthma in the frame of a population-based study. Methods: For this purpose, data collected from the Gene Environment Interactions in Respiratory Diseases (GEIRD) Study, an Italian multicentre, multicase-control study, was evaluated. Cases and controls were identified through a two-stage screening process of individuals aged 20-65 years from the general population. Out of 16,569 subjects selected from the general population in the first stage of the survey, 2259 participated in the clinical evaluation. Oxidative stress biomarkers such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), 8-isoprostane and glutathione and inflammatory biomarkers such as Fractional Exhaled Nitric Oxide (FENO) and white blood cells were evaluated in 1878 subjects. Results: Current asthmatics presented higher levels of FENO (23.05 ppm), leucocytes (6770 n/µL), basophils (30.75 n/µL) and eosinophils (177.80 n/µL), while subjects with chronic bronchitis showed higher levels of GSH (0.29 mg/mL) and lymphocytes (2101.6 n/µL). The multivariable multinomial logistic regression confirmed high levels of leucocytes (RRR = 1.33), basophils (RRR = 1.48), eosinophils (RRR = 2.39), lymphocytes (RRR = 1.26) and FENO (RRR = 1.42) in subjects with current asthma. Subjects with past asthma had a statistically significant higher level of eosinophils (RRR = 1.78) with respect to controls. Subjects with chronic bronchitis were characterized by increased levels of eosinophils (RRR = 2.15), lymphocytes (RRR = 1.58), GSH (RRR = 2.23) and 8-isoprostane (RRR = 1.23). Conclusion: In our study, current asthmatics show a greater expression of the inflammatory profile compared to subjects who have had asthma in the past and chronic bronchitis. On the other hand, chronic bronchitis subjects showed a higher rate of expression of oxidative stress biomarkers compared to asthmatic subjects. In particular, inflammatory markers such as circulating inflammatory cells and FENO seem to be more specific for current asthma, while oxidative stress biomarkers such as glutathione and 8-isoprostane appear to be more specific and applicable to patients with chronic bronchitis.

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Curcumin effects on chronic obstructive pulmonary disease: A systematic review

Safari

Davoodi

Soltani

et al. 2023

Health Science Reports

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Introduction Chronic obstructive pulmonary disease (COPD) is a common disease of the lungs known as the third reason for death worldwide. Frequent COPD exacerbations compel health care workers to apply interventions that are not adverse effect free. Accordingly, adding or replacing Curcumin, a natural meal flavoring, may indicate advantages in this era by its antiproliferative and anti‐inflammatory effects. Methods The PRISMA checklist was employed for the systematic review study. On June 3, 2022, PubMed/Medline, Scopus, and Web of Science were searched for studies associated with COPD and Curcumin in the last 10 years. Duplicate or non‐English publications and articles with irrelevant titles and abstracts were excluded. Also, preprints, reviews, short communications, editorials, letters to the editor, comments, conference abstracts, and conference papers were not included. Results Overall, 4288 publications were found eligible, after the screening, 9 articles were finally included. Among them, one, four, and four in vitro, in vivo, and both in vivo and in vitro research exist respectively. According to the investigations, Curcumin can inhibit alveolar epithelial thickness and proliferation, lessen the inflammatory response, remodel the airway, produce ROS, alleviate airway inflammation, hinder emphysema and prevent ischemic complications. Conclusion Consequently, the findings of the current review demonstrate that Curcumin's modulatory effects on oxidative stress, cell viability, and gene expression could be helpful in COPD management. However, for data confirmation, further randomized clinical trials are required.

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Reliability and Usefulness of Different Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease

Cited by 35 publications

References 119 publications

Serum Albumin Concentrations in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Serum Albumin Concentrations in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases

Curcumin effects on chronic obstructive pulmonary disease: A systematic review

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