Curcumin effects on chronic obstructive pulmonary disease: A systematic review

Abstract

Introduction Chronic obstructive pulmonary disease (COPD) is a common disease of the lungs known as the third reason for death worldwide. Frequent COPD exacerbations compel health care workers to apply interventions that are not adverse effect free. Accordingly, adding or replacing Curcumin, a natural meal flavoring, may indicate advantages in this era by its antiproliferative and anti‐inflammatory effects. Methods The PRISMA checklist was employed for the systematic review study. On June 3, 2022, PubMed/Medline, Scopus, and Web of Science were searched for studies associated with COPD and Curcumin in the last 10 years. Duplicate or non‐English publications and articles with irrelevant titles and abstracts were excluded. Also, preprints, reviews, short communications, editorials, letters to the editor, comments, conference abstracts, and conference papers were not included. Results Overall, 4288 publications were found eligible, after the screening, 9 articles were finally included. Among them, one, four, and four in vitro, in vivo, and both in vivo and in vitro research exist respectively. According to the investigations, Curcumin can inhibit alveolar epithelial thickness and proliferation, lessen the inflammatory response, remodel the airway, produce ROS, alleviate airway inflammation, hinder emphysema and prevent ischemic complications. Conclusion Consequently, the findings of the current review demonstrate that Curcumin's modulatory effects on oxidative stress, cell viability, and gene expression could be helpful in COPD management. However, for data confirmation, further randomized clinical trials are required.

Metabolic regularity of bioactive compounds in Bufei Jianpi granule in rats using ultra‐high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry analysis technology

“…Furthermore, BJG is mainly applied in clinical practice to treat COPD, and the vicious cycle of inflammation and oxidative stress is a prominent manifestation in COPD patients (Safari et al, 2023). The 10 blood components tested in this study exhibited anti‐inflammatory, antioxidant, analgesic, and other biological activities to varying degrees.…”

“…Furthermore, BJG is mainly applied in clinical practice to treat COPD, and the vicious cycle of inflammation and oxidative stress is a prominent manifestation in COPD patients (Safari et al, 2023).…”

Phenotypical and molecular assessments on the pharmacological effects of curcumin in Drosophila melanogaster

“…Studies have revealed that curcumin, a dietary polyphenol derived from the turmeric rhizome, offers therapeutic advantages in COPD by suppressing nuclear factor kappa B (NF-κB) [ 11 ]. Curcumin’s modulatory effects on oxidative stress, cell viability, and gene expression may benefit COPD therapy [ 12 ]. Due to its chemical contains, curcumin possesses a strong antioxidant potential that is almost three times greater than that of vitamin C and more than 1.5 times greater than that of vitamin E [ 13 ].…”

Nanocurcumin supplementation improves pulmonary function in severe COPD patients: A randomized, double blind, and placebo‐controlled clinical trial

“…Many systemic manifestations of COPD are believed to be exacerbated by systemic inflammation, including elevated IL-6 levels. Various animal and cellular studies have shown the promising effect of curcumin on COPD, and their results have been discussed in a systematic review study (Safari et al, 2023). In the only clinical trial study, in this issue, Funamoto et al (2016) showed that the administration of curcumin significantly reduced the level of atherosclerotic low-density lipoprotein compared to the control group in non-smoker patients with mild COPD.…”