Well-defined high molecular weight polyglycolide-b-poly(L-)lactide-b-polyglycolide triblock copolymers: synthesis, characterization and microstructural analysis

Ayyoob, Muhammad; Lee, Seungmook; Kim, Young Jun

doi:10.1007/s10965-019-2001-4

Cited by 10 publications

(10 citation statements)

References 50 publications

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“…The heat of melting (ΔH m ) was 38.2 and 13.3 J/g for the PLA and PGA blocks, respectively (data not shown). These results were concurrent with previously reported data [ 16 ].…”

Section: Resultssupporting

confidence: 94%

“…Here, two new peaks appeared at 169.2 and 61.4 ppm with the addition of glycolic acid (b-PLLGA), and the resonance signals were attributed to the homo-sequences centered on the carbonyl region of the glycolidyl (−GGGG– at 169.2 ppm) and the methylene (−GGGG– at 61.4 ppm) regions. The peak intensity of the glycolidyl moiety increased at a higher glycolic acid feed ratio [ 16 ]. The PGA–PLA block copolymers were only soluble in HFIP.…”

Section: Resultsmentioning

confidence: 99%

“…The method of synthesis of b-PLLGA, as previously reported [ 16 ], is illustrated in Figure 1 B. Briefly, LA and GL were recrystallized twice and dried under vacuum at 80 °C for 24 h before being stored at room temperature over a desiccant.…”

Section: Materials and Experimentalmentioning

confidence: 99%

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In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

et al. 2020

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Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

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“…The heat of melting (ΔH m ) was 38.2 and 13.3 J/g for the PLA and PGA blocks, respectively (data not shown). These results were concurrent with previously reported data [ 16 ].…”

Section: Resultssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

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In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

et al. 2020

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“…Another effective method for reducing the negative effect of oligomeric oxyacid impurities present in lactide is the combination of polymerization and polycondensation processes for the synthesis of polylactide. Specially selected conditions for increasing the induction period of polymerization by lowering the temperature lead to a decrease in the polymerization rate in an open system, and the condensation of impurities and the removal of the resulting water reduce the concentration of chain transmitters [124].…”

Section: Polyesters and Polyesteramidesmentioning

confidence: 99%

“…e advantages of the method in comparison with the batch technology are the homogeneity of mixing and heat transfer of the entire reaction mass, the absence of low molecular weight fractions, a narrow molecular weight distribution, and the exclusion of the polymer granulation stage. All these lead to a decrease in the cost of polylactide and ensure the production of wares with high-performance characteristics [124].…”

Section: Polyesters and Polyesteramidesmentioning

confidence: 99%

An Overview of the Main Trends in the Creation of Biodegradable Polymer Materials

Vikhareva

Buylova

Yarmuhametova

et al. 2021

Journal of Chemistry

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Plastic is one of the most demanded materials on the planet, and the increasing consumption of which contributes to the accumulation of significant amounts of waste based on it. For this reason, a new approach to the development of these materials has been formed: the production of polymers with constant operational characteristics during the period of consumption and capable of then being destroyed under the influence of environmental factors and being involved in the metabolic processes of natural biosystems. The paper outlines the prerequisites for the development of the field of creating biodegradable composite materials, as well as the main technical solutions for obtaining such polymeric materials. The main current solutions for reducing and regulating the degradation time of polymer materials are presented. The most promising ways of further development of the field of bioplastics production are described. Common types of polymers based on renewable raw materials, composites with their use, and modified materials from natural and synthetic polymers are considered.

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Kontrolle über Chaos und Ordnung: Gegensätzliche Mikrostrukturen von PCL‐co‐PGA‐co‐PLA durch einen einzigen Katalysator zugänglich**

et al. 2022

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Ein Katalysator, zwei Reaktionsaufbauten, drei Monomere und unbegrenzte Möglichkeiten für makromolekulare Mikrostrukturen: Der Eisen‐Guanidin‐Komplex [FeCl2(TMG5NMe2asme)] (1) polymerisiert Lactid schneller als das industriell verwendete Zinnoktanoat und zeigt hohe Aktivitäten für Glycolid und ϵ‐Caprolacton. Seine herausragenden Eigenschaften ermöglichen die Synthese von blockförmigen sowie randomisierten Copolymeren in der Schmelze durch eine einfache Änderung des Polymerisationsaufbaus. Die sequenzielle Zugabe von Monomeren führt zu hoch geordneten Blockcopolymeren, einschließlich der symmetrischen PLA‐b‐PGA‐b‐PCL‐b‐PGA‐b‐PLA‐Pentablockcopolymere, während die Polymerisation von Monomermischungen starke Umesterungen nutzt, um zu Di‐ und Terpolymeren mit hochdisperser Verteilung der Wiederholungseinheiten zu kommen. Ein robuster Katalysator, der unter industriell anwendbaren Bedingungen aktiv ist und Copolymere mit gewünschten Mikrostrukturen herstellt, ist ein wichtiger Schritt in Richtung biokompatibler Polymere mit maßgeschneiderten Eigenschaften als Alternative zu herkömmlichen Kunststoffen auf dem Weg zu einer nachhaltigen Kreislaufführung von Materialien.

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Well-defined high molecular weight polyglycolide-b-poly(L-)lactide-b-polyglycolide triblock copolymers: synthesis, characterization and microstructural analysis

Cited by 10 publications

References 50 publications

In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

An Overview of the Main Trends in the Creation of Biodegradable Polymer Materials

Kontrolle über Chaos und Ordnung: Gegensätzliche Mikrostrukturen von PCL‐co‐PGA‐co‐PLA durch einen einzigen Katalysator zugänglich**

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