In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

Yoon, Seung Kyun; Yang, Jin Ho; Lim, Hyun‐Tae; Chang, Young‐Wook; Ayyoob, Muhammad; Yang, Xin; Kim, Young Jun; Ko, Han-Seung; Jho, Jae Young; Chung, Dong June

doi:10.3390/polym13010029

Cited by 10 publications

(10 citation statements)

References 22 publications

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“…As a material with a relatively slow degradation rate, PLLA may cause some problems, such as incomplete degradation and lower local pH. Therefore, PLLA implants may cause late inflammation, cell necrosis, and delayed axonal recovery in the body [91], which should also be considered for future clinical applications.…”

Section: Topography Affects Cell Alignment Growth and Neuritementioning

confidence: 99%

The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review

Liu

et al. 2021

Stem Cells International

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The surface topographies of artificial implants including surface roughness, surface groove size and orientation, and surface pore size and distribution have a great influence on the adhesion, migration, proliferation, and differentiation of nerve cells in the nerve regeneration process. Optimizing the surface topographies of biomaterials can be a key strategy for achieving excellent cell performance in various applications such as nerve tissue engineering. In this review, we offer a comprehensive summary of the surface topographies of nerve implants and their effects on nerve cell behavior. This review also emphasizes the latest work progress of the layered structure of the natural extracellular matrix that can be imitated by the material surface topology. Finally, the future development of surface topographies on nerve regeneration was prospectively remarked.

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Section: Topography Affects Cell Alignment Growth and Neuritementioning

confidence: 99%

The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review

Liu

et al. 2021

Stem Cells International

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“…Later, synthetic polymer-based fluid loss agents evolved as a kind of natural material modification, improving the temperature resistance. Graft copolymerization was used to alter starch using monomers such as acrylamide, acrylic acid, 2-acrylamido-2-methylpropane sulfonic acid, and dimethyldiallylammonium chloride. − While the environmental acceptability quality of these starch graft copolymers looks to be sufficient and meets the ever-increasing environmental standards, the method by which these composites were created is unknown. To guarantee efficient and secure drilling, it is crucial to create high-temperature-resistant fluid loss agents for drilling fluids. − Moreover, ion exchange processes are anticipated in high-salinity formations where the salt concentration in the drilling fluid is similar to the salt concentration in the formation, resulting in drilling fluid instability.…”

Section: Introductionmentioning

confidence: 99%

Nano-Grafted Acrylamide Copolymer as an Anti-Temperature and Anti-Calcium Fluid Loss Agent for Water-Based Drilling Fluids

Pang

Yang

et al. 2023

Energy Fuels

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When the well bottom temperature rises owing to increased well depth and formation complexity, the inadequacies of naturally modified polymeric fluid loss agents were revealed one by one, and synthetic polymeric fluid loss agents emerged as the essential technology to handle these problems. Nanomaterials were gradually being employed to increase the performance of polymeric fluid loss agents. Through free radical polymerization of amide polymers with silica nanoparticles in aqueous solution, a novel nano-graft copolymer (AAN-g-SiO2) was prepared for usage as a water-based drilling fluid loss agent. Fourier transform infrared spectroscopy and thermogravimetric analyses were used to investigate the structural characteristics and thermal stability of the polymer chains. Then, 4% bentonite freshwater-based mud and different concentrations of NaCl/CaCl2-based mud were prepared and added to the fluid loss agent AAN-g-SiO2. Moreover, high-temperature aging was carried out, and the API filtration volume of base mud and rheological characteristics were assessed. The fluid loss agent was demonstrated to withstand a high temperature of 220 °C, with the freshwater-based mud filtration volume at this temperature being 13.25 mL. Also, at 180 °C, AAN-g-SiO2 could be resistant to calcium and salt. Finally, we addressed the mechanism of AAN-g-SiO2 filtration using scanning electron microscopy and zeta potential distribution. The results showed that the inclusion of AAN-g-SiO2 may increase the stability of the drilling fluid system, resulting in the production of a thin and dense filter cake with no folds or pores visible at the microscopic level.

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“…Biodegradable aliphatic polyesters such as PCL and PLA, endowed with semicrystallinity and biodegradability due to their potentially hydrolyzable ester bonds, have been widely used as scaffolds in tissue engineering, drug delivery systems, packaging, and biomedical applications, because of their controlled biodegradability, biocompatibility, and good physical properties [1][2][3]. It has been reported that, compared to PLA, the degradation period of PCL can range from several months to a few years, and its biodegradability is dependent on its molecular weight, degree of crystallinity, and degradation conditions.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks

et al. 2021

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Biodegradable triblock copolymers based on poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) were synthesized via ring-opening polymerization of L-lactide followed by reversible addition–fragmentation chain-transfer (RAFT) polymerization of poly(methyl vinyl ketone) (PMVK) as a photodegradable block, and characterized by FT-IR and 1H NMR spectroscopy for structural analyses, and by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) for their thermal properties. Porous, biodegradable PCL-b-PLA microspheres were fabricated via the oil/water (O/W) emulsion evaporation method, followed by photodegradation of PMVK blocks by UV irradiation. The macro-chain transfer agent (CTA) synthesized by reacting a carboxylic-acid-terminated CTA—S-1-dodecyl-S′-(a,a′-dimethyl-a′′-acetic acid)trithiocarbonate (DDMAT)—with a hydroxyl-terminated PCL-b-PLA block copolymer was used to synthesize well-defined triblock copolymers with methyl vinyl ketone via RAFT polymerization with controlled molecular weights and narrow polydispersity. Gel permeation chromatography traces indicated that the molecular weight of the triblock copolymer decreased with UV irradiation time because of the photodegradation of the PMVK blocks. The morphology of the microspheres before and after UV irradiation was investigated using SEM and videos of three-dimensional confocal laser microscopy, showing a change in their surface texture from smooth to rough, with high porosity owing to the photodegradation of the PMVK blocks to become porous templates.

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In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

Cited by 10 publications

References 22 publications

The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review

The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review

Nano-Grafted Acrylamide Copolymer as an Anti-Temperature and Anti-Calcium Fluid Loss Agent for Water-Based Drilling Fluids

Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks

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