Weight Gain Prior to Diagnosis and Survival from Breast Cancer

Cleveland, Rebecca J.; Eng, Sybil M.; Abrahamson, Page E.; Britton, Julie A.; Teitelbaum, Susan L.; Neugut, Alfred I.; Gammon, Marilie D.

doi:10.1158/1055-9965.epi-06-0889

Cited by 122 publications

(116 citation statements)

References 42 publications

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“…The association between obesity and poor overall survival [18,[24][25][26] or prognosis of breast cancer [17,[27][28][29], might, if also true for BRCA1/2 carriers, have influenced our study results. The inclusion of prevalent cases, may have led toward bias to the null, overweight/obese prevalent cases may have been underrepresented because they had died prior to study entry [24,27,28].…”

Section: Discussionmentioning

confidence: 88%

“…The inclusion of prevalent cases, may have led toward bias to the null, overweight/obese prevalent cases may have been underrepresented because they had died prior to study entry [24,27,28]. We reduced this potential survival bias by restricting the analyses to personyears within 10 years prior to questionnaire completion.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed that excess body weight (defined as overweight (BMI between 25.0 and 29.9 kg/m 2 ) or obesity (BMI C 30.0 kg/m 2 ) decreases overall survival [18,[24][25][26] and breast cancer-specific survival [17,[27][28][29]. The association between obesity and poor prognosis of breast cancer was present in both pre-and postmenopausal carriers.…”

Section: Analytic Cohortmentioning

confidence: 99%

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Body weight and risk of breast cancer in BRCA1/2 mutation carriers

Manders

Pijpe²,

Hooning

et al. 2010

Breast Cancer Res Treat

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Obesity is an established risk factor for postmenopausal breast cancer in the general population. However, it is still unclear whether this association also exists in BRCA1/2 mutation carriers. We investigated the association between self-reported anthropometric measures and breast cancer risk in a nationwide retrospective cohort study, including 719 BRCA1/2 carriers, of whom 218 had been diagnosed with breast cancer within 10 years prior to questionnaire completion. All time-varying Cox proportional hazards analyses were stratified by menopausal status. For premenopausal breast cancer, no statistically significant associations were observed for any of the anthropometric measures. The association between body mass index (BMI) at age 18 and premenopausal breast cancer risk suggested a trend of decreasing risk with increasing BMI 123Breast Cancer Res Treat (2011) 126:193-202 DOI 10.1007/s10549-010-1120 5 kg or more, and a relative adult weight gain of 20% or more were all non-significantly associated with a 50-60% increased risk of postmenopausal breast cancer [HR = 1.46 (0.86-2.51), HR = 1.56 (95% CI = 0.85-2.87), and HR = 1.60 (95% CI = 0.97-2.63), respectively], when compared with having a healthy or stable weight. No associations for body weight or BMI at age 18 were observed. In conclusion, menopausal status seemed to modify the association between body weight and breast cancer risk among BRCA1/2 carriers. We observed no clear association between body weight and premenopausal breast cancer, while overweight and weight gain increased postmenopausal breast cancer risk. Carriers may reduce their risk of postmenopausal breast cancer by maintaining a healthy body weight throughout life.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Analytic Cohortmentioning

confidence: 99%

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Body weight and risk of breast cancer in BRCA1/2 mutation carriers

Manders

Pijpe²,

Hooning

et al. 2010

Breast Cancer Res Treat

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“…Among those linked to nutritional status, those related to body composition, such as obesity and/or overweight and inadequate distribution of body fat, especially in the post-menopause, are noteworthy 4 .…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Antropometria e perfil lipídico em mulheres com câncer de mama: um estudo caso-controle

Martins¹,

Freitas‐Junior²,

Monego³

et al. 2012

Rev. Col. Bras. Cir.

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OBJETIVO: avaliar a composição corporal e o perfil lipídico de mulheres com e sem câncer de mama. MÉTODOS: estudo caso-controle pareado por idade, incluindo 62 mulheres, sendo 31 recém-diagnosticadas com câncer de mama e 31 com alterações mamárias benignas. Os dados foram coletados por meio de entrevista direta, com caracterização sociodemográfica, avaliação da composição corporal por antropometria, incluindo dobras cutâneas (DC) e circunferências, bioimpedância (BIA) e ultrassonografia (USG), além da avaliação do perfil lipídico. Utilizou-se na análise dos dados: Teste de Kolmogorov-smirnov (distribuição normal das variáveis), teste "t" de Student, Qui-quadrado de tendência (U de Mann-Whitney), Qui-quadrado de Pearson, Teste Exato de Fisher e Correção de Yates e "odds ratio". RESULTADOS: comparadas aos controles, mulheres com câncer de mama (casos) apresentaram menor estatura (1,56m±5,68) e (1,59m±6,92), p<0,03; maior porcentagem de gordura corporal, avaliada pela Impedância Bioelétrica (39,87% ±8,26) e (36,00%±6,85), p<0,049; maior dobra cutânea tricipital (27,55mm±8,37 e 22,81mm±5,72; p<0,01), respectivamente. CONCLUSÃO: Mulheres com câncer de mama apresentaram menor estatura, maior porcentagem de gordura corporal e maior dobra cutânea tricipital. Não se observou diferença no Índice de Massa Corporal e na Circunferência da Cintura. Não foi encontrada associação entre o perfil lipídico e a ocorrência de câncer de mama.

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“…[1][2][3][4][5] Aromatization of androstenedione to estradiol in the peripheral adipose tissue and low levels of sex-hormonebinding globulin have been postulated as the primary biological mechanism; [6][7][8] however, other biological pathways such as increased serum levels of insulin-like growth factors have been proposed as well. 9 Among all the pathological prognostic indicators, the combination of stage and grade of cancer is the best predictor of DFS and OS. [10][11] Therefore, if obesity is a risk factor for breast cancer and if it is an independent predictor for DFS and OS, obese compared with normal weight women should have an elevated risk for cancers with more adverse prognostic indicators.…”

Section: Introductionmentioning

confidence: 99%

Body mass index at the time of diagnosis and the risk of advanced stages and poorly differentiated cancers of the breast: findings from a case-series study

et al. 2010

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Introduction: Obesity is a risk factor for postmenopausal breast cancer and is independently associated with shorter disease-free and overall survival. Currently, in clinical settings, the combination of stage and grade of cancer at the initial presentation of the disease is the best prognostic indicator. Objective: To evaluate the association between body mass index (BMI) and risk of advanced stages and poorly differentiated grade of breast cancer. Design: A case-series study of women diagnosed with their first primary invasive breast cancer. Patients include a total of 831 women aged X40 years with a mean BMI of 29.6( ± 6.6) kg m À2 . Pathological, clinical and demographic data were retrieved from electronic medical records. Multinomial logistic regression analysis was preformed to estimate the risk of more advanced stages and poorly differentiated grade of cancer, adjusting for covariates. Results: Obese compared with normal weight women had an 80% increased risk of cancer with more advanced stages (III/IV) and poorly differentiated grade (odds ratio ¼ 1.80, 95% confidence interval 1.13-2.86, P ¼ 0.014). No significant increase in risk was observed for overweight women. Conclusion: Obesity at the time of diagnosis of breast cancer is associated with more advanced stages and poorly differentiated grade of cancers.

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Weight Gain Prior to Diagnosis and Survival from Breast Cancer

Cited by 122 publications

References 42 publications

Body weight and risk of breast cancer in BRCA1/2 mutation carriers

Body weight and risk of breast cancer in BRCA1/2 mutation carriers

Antropometria e perfil lipídico em mulheres com câncer de mama: um estudo caso-controle

Body mass index at the time of diagnosis and the risk of advanced stages and poorly differentiated cancers of the breast: findings from a case-series study

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