Wegener's granulomatosis: The current understanding

Ponniah, I.; Shaheen, Ahmed; Shankar, KB; Kumaran, M.G.

doi:10.1016/j.tripleo.2005.04.018

Cited by 52 publications

(24 citation statements)

References 35 publications

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“…The mean delay between the onset of symptoms and the eventual diagnosis ranges from 2–20 months. 1 Wegener's granulomatosis is more prevalent in men; more than 90% of cases primarily affects Caucasian men in their fifth decade 2 at a median age of 59 years. 3 Although reported in middle age, cases have been reported in the literature of both much younger (13 years) 4 and older patients (71 years) 2 at initial presentation.…”

Section: Discussionmentioning

confidence: 99%

“…1 With the correct therapeutic dosing, response to treatment is almost immediate and is aimed at inducing remission; tapering of cyclophosphamide and prednisolone therapy at a later stage, however, may precede a relapse. 2 Side-effects of immunosuppressive therapy are dose-dependent and may include haemorrhagic cystitis, myelodysplastic syndrome and severe infections.…”

Section: Discussionmentioning

confidence: 99%

“…Reported mortality of Wegener's granulomatosis remains considerably high at 14.6%; 3 however, with strict adherence to treatment regimes and regular monitoring of disease progression, five-year survival rate is reported to be 76%. 1 …”

Section: Discussionmentioning

confidence: 99%

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Wegener's granulomatosis in primary care

Paddock

Lynch²,

Paska

2010

JRSM Short Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Wegener's granulomatosis in primary care

Paddock

Lynch²,

Paska

2010

JRSM Short Reports

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“…Induction treatment is usually given as combined treatment with cyclophosphamide and corticosteroids. 60 Use of corticosteroids alone is associated with a higher relapse rate. The roles of anti-T-cell or anti-cytokine therapy in this situation are presently being tested.…”

Section: Ehlers-danlos Syndromementioning

confidence: 99%

Autoimmune Disorders – Immunopathogenesis and Potential Therapies

Ganapathy¹,

Vedam²,

Rajeev³

et al. 2017

JYP

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Autoimmune disorders are formed in the body as an outcome of inappropriate immune response against its own tissues. Failure of this immune system to recognize the body's normal constituents as "self" will result in inflammation and tissue damage. Several immune based mechanisms form the basis of autoimmune disorders in the body. Management of these lesions is based on the diagnostic criteria, evaluation of clinical and oral manifestation, and laboratory investigations of these lesions. There is currently no definitive cure for all autoimmune disorders, although in rare cases they may disappear on their own. As patients experience temporary remissions in symptoms or progressive worsening, our pharmacological management are targeted only for symptomatic relief and arrest the progression of the lesion. A detailed approach to titles and abstracts of importance in this field on the topic of interest via review and case reports was included. This review article highlights on various immune pathogenic mechanisms and treatment modalities of autoimmune disorders.

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“…Wegener's granulomatosis is an uncommon multi-organ disease first categorized as a distinct syndrome by Friedreich Wegener in 1936 [1-3] The hallmarks of this potentially fatal disorder are necrotizing granulomatous inflammation involving the upper and lower respiratory tract, glomerulonephritis, and vasculitis [3-6]. Wegener's granulomatosis may occur as a limited or generalized disease.…”

Section: Introductionmentioning

confidence: 99%

Strawberry gingivitis as the first presenting sign of wegener's granulomatosis: report of a case

et al. 2011

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Wegener's granulomatosis is a rare multi-system disease characterized by the classic triad of necrotizing granulomas affecting the upper and lower respiratory tracts, disseminated vasculitis and glomerulonephritis. Oral lesions as a presenting feature are only encountered in 2% of these cases. Hyperplastic gingival lesions or strawberry gingivitis, is a characteristic sign of Wegener's granulomatosis. The latter consists of reddish-purple exophytic gingival swellings with petechial haemorrhages thus resembling strawberries. Recognition of this feature is of utmost importance for timely diagnosis and definitive management of this potentially fatal disease. A case of strawberry gingivitis as the first presenting sign of Wegener's granulomatosis affecting a 50-year-old Malay male is reported here. The differential diagnosis of red lesions that may present in the gingiva is discussed.

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Wegener's granulomatosis: The current understanding

Cited by 52 publications

References 35 publications

Wegener's granulomatosis in primary care

Wegener's granulomatosis in primary care

Autoimmune Disorders – Immunopathogenesis and Potential Therapies

Strawberry gingivitis as the first presenting sign of wegener's granulomatosis: report of a case

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