Autoimmune Disorders – Immunopathogenesis and Potential Therapies

Abstract

Autoimmune disorders are formed in the body as an outcome of inappropriate immune response against its own tissues. Failure of this immune system to recognize the body's normal constituents as "self" will result in inflammation and tissue damage. Several immune based mechanisms form the basis of autoimmune disorders in the body. Management of these lesions is based on the diagnostic criteria, evaluation of clinical and oral manifestation, and laboratory investigations of these lesions. There is currently no definitive cure for all autoimmune disorders, although in rare cases they may disappear on their own. As patients experience temporary remissions in symptoms or progressive worsening, our pharmacological management are targeted only for symptomatic relief and arrest the progression of the lesion. A detailed approach to titles and abstracts of importance in this field on the topic of interest via review and case reports was included. This review article highlights on various immune pathogenic mechanisms and treatment modalities of autoimmune disorders.

Understanding Skin Failure: A Scoping Review

“…These conditions exist on a spectrum of severity and result from an autoimmune disorder or, in the case of burn injuries, trauma. An autoimmune disease causes a person’s immune system to attack the body’s own tissues and organs 191 . For example, pemphigus, an autoimmune blistering disease, impacts the skin when antibodies erroneously attack proteins that are essential for the layers of skin to adhere together 187 .…”

A review of applications of Raman spectroscopy in immunology

“…At the beginning of the twentieth century, the concept of autoimmunity was first suggested by Noble laureate Paul Ehrlich who defined it as 'horror autotoxicus' [32]. Autoimmunity is the failure of the immune system to distinguish between the endogenous and exogenous antigens, and thereby its misdirection of the immune response against the body itself [21]. The breakdown mechanism responsible for self-tolerance or aberrant response of the body's immune system to endogenous-antigens leads to the pathogenesis of an autoimmune disorder [21].…”

“…Autoimmunity is the failure of the immune system to distinguish between the endogenous and exogenous antigens, and thereby its misdirection of the immune response against the body itself [21]. The breakdown mechanism responsible for self-tolerance or aberrant response of the body's immune system to endogenous-antigens leads to the pathogenesis of an autoimmune disorder [21]. Autoimmune disorders are the third-most prevalent category of disease in the industrialised world, following cardiovascular disease and cancer [15,60].…”

Mindfulness Based Therapies for Autoimmune Diseases and Related Symptoms

“…There are multiple autoimmune diseases known to modern medicine, including inflammatory diseases such as rheumatoid arthritis, psoriatic arthritis, and multiple sclerosis, among others. Specific symptoms associated with these diseases include chronic fatigue, joint and other pain, swelling, skin rashes, and anemia [1]. Symptoms range from subtle to life-threatening, often wax and wane, and impact multiple organ systems [1].…”

“…Specific symptoms associated with these diseases include chronic fatigue, joint and other pain, swelling, skin rashes, and anemia [1]. Symptoms range from subtle to life-threatening, often wax and wane, and impact multiple organ systems [1]. Autoimmune disease appears to be on the rise [2].…”