Wegener's Granulomatosis of the Breast

Veerysami, Mangal; Freeth, Martin; Carmichael, Amtul R.; Carmichael, Paul L.

doi:10.1111/j.1075-122x.2006.00254.x

Cited by 23 publications

(11 citation statements)

References 14 publications

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“…While the aetiology of true idiopathic granulomatous mastitis is unclear, granulomatous disease within the breast may also be secondary and represent a manifestation of a systemic disease such as Wegener's granulomatosis [9], sarcoidosis, diabetes mellitus, or the connective tissue disorders. Little, however, has been written about this topic [10].…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Mastitis: A Spectrum of Disease

2009

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Background: Granulomatous disease within the breast can result from a variety of causes. Patients and Methods: We present 3 cases of this condition with 3 different underlying diagnoses. Results: Each case was initially labelled as idiopathic granulomatous mastitis, although this was proven not to be correct on further investigation. Conclusion: Clearly, identifying the correct underlying diagnosis is essential in granulomatous breast lesions as the treatment varies widely depending on the underlying aetiology. Effective communication and feedback in the context of the multidisciplinary team are vital to the diagnostic process in such challenging cases.

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Section: Discussionmentioning

confidence: 99%

Granulomatous Mastitis: A Spectrum of Disease

2009

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“…Systemic vasculitis involving the breast has been sporadically reported as a component of different systemic vasculitides, such as GCA [57], PAN [58], Churg-Strauss syndrome [59], Behçet's disease [60] and Wegener's granulomatosis [52,61,62].…”

Section: Single-organ Vasculitis Involving the Breastmentioning

confidence: 99%

Single-organ vasculitis

Hernández‐Rodríguez

Molloy

Hoffman

2008

Current Opinion in Rheumatology

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“…In 60% (12) of the cases [2-4, 7, 9-14, 16, 18], the condition improved with prednisone treatment and in 10% (2) of the cases [14], including our case, with NSAID treatment. A previous report has described the case of one patient with PAN [23] where the painful mass of mammary Carcinoma or mastitis Prednisone 30 mg/d tissue developed central necrosis after surgical debridement, and this eventually led to ulceration of the breast skin; however, no such case has been reported for patients with GCA.…”

Section: Discussionmentioning

confidence: 99%

“…A definitive diagnosis of GCA is a welcome relief for both patients and their physicians because of the associated expectation that the symptoms will gradually improve with NSAID or prednisone treatment. Interestingly, some cases of WG [22,23] have been reported, wherein the breast seemed to be the first organ involved and the manifestations resembled those of mammary GCA. In such cases, where subclinical manifestations are present in organs other than the breasts, delayed diagnosis and inadequate initial treatment may give rise to lethal conditions, including organ failure; therefore, it is important to establish an accurate early differential diagnosis by performing a biopsy.…”

Section: Discussionmentioning

confidence: 99%

Giant cell arteritis of the breast: a case report with a review of literatures

et al. 2009

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Although giant cell arteritis (GCA), clinically designated as temporal arteritis, is recognized as a systemic disease, the breast may be the primary organ in which it is manifested. GCA of the breast is a rare disease that mainly occurs in postmenoposal elderly women. It manifests as nodules or pain in the breast, with or without tenderness, and is associated with significant constitutional symptoms that resemble those of polymyalgia rheumatica (PMR). These symptoms can be treated with or without prednisone therapy and can improve without the development of organ dysfunction. The clinical manifestations can often be recognized only by retrospective analysis after excisional biopsy. GCA of the breast occasionally mimics carcinoma, and its initial manifestations may be similar to those of other forms of vasculitis involving the breast, such as polyarteritis nodosa and Wegener granulomatosis. Biopsy is indispensable for establishing a definitive diagnosis. Thus far, the findings of imaging procedures, such as mammography and ultrasonography, for patients with mammary GCA have not been reported in detail, and no distinctive findings associated with this condition have been identified. Considering this and the fact that spontaneous remission may occur in some cases, mammary GCA probably often goes undiagnosed or may be misdiagnosed as an ordinary mammary disease. GCA of the breast should be considered as a potential diagnosis in the case of elderly women presenting with PMR-like symptoms and tenderness, lumps, or pain in the breast. We report a case of GCA affecting the breast and review previous reports on this condition in an attempt to summarize the features that distinguish this disease from other vascular diseases of the breast.

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Wegener's Granulomatosis of the Breast

Cited by 23 publications

References 14 publications

Granulomatous Mastitis: A Spectrum of Disease

Granulomatous Mastitis: A Spectrum of Disease

Single-organ vasculitis

Giant cell arteritis of the breast: a case report with a review of literatures

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