Single-organ vasculitis

Abstract

The diagnosis of focal single-organ vasculitis is always presumptive and requires exclusion of systemic illness at the time of diagnosis as well as throughout the period of continued care. Clues from clinical symptoms, laboratory tests and histopathologic features at the time of diagnosis may assist in devising surveillance strategies.

Comparison of clinical and pathological characteristics of isolated aortitis and Takayasu arteritis with ascending aorta involvement

“…It is very important to make this differential diagnosis because of the different treatment and prognosis of these two diseases 2 9. We have shown that patients with IA had less intimal thickening than patients with TA, which is similar to the finding of Miller et al 3.…”

“…We also found that the vascular lesions were more localised and there were fewer additional vascular lesions outside the ascending aorta in the patients with IA. Ascending aortic aneurysm is the most common presentation of IA with a prevalence of 96%,2 compared with a significantly lower prevalence of 8.4% and 11%, respectively, in Chinese and Japanese patients with TA 13–15. However, additional vascular abnormalities were detected in 72% of cases with non-infectious ascending aortitis, most of whom had IA 9.…”

“…Isolated aortitis (IA) has increasingly been recognised as a new entity of non-infectious aortitis 1 2. This kind of aortitis is usually localised in the ascending aorta and lacks infection, systemic disorder or rheumatological abnormalities.…”

“…Its prognosis appears to be good after surgery. Unlike Takayasu arteritis (TA), it is not usually treated with corticosteroids 2. To our knowledge, the comparison between IA and other common non-infectious aortitis such as TA and giant cell aortitis has not been well studied because of their relative rarity and difficulty in diagnosis among pathologists 3.…”

Manifestations digestives et ischémie mésentérique au cours des vascularites systémiques

“…On ne peut pas exclure qu'une infection bactérienne « banale » de l'appendice puisse en soi, au moins dans quelques cas, provoquer une réaction inflammatoire locale de type vascularite, infectieuse et réactionnelle simplement. Peu d'études existent sur les risques d'évolution vers une authentique vascularite systémique en cas de vascularite appendiculaire isolée et révélatrice ou, plus généralement, de forme digestive localisée et isolée de vascularite, vésicu-laire par exemple [42][43][44]. Dans une première étude, sur neuf patients avec vascularite de l'appendice, aucun n'a développé d'atteinte systémique après presque sept ans de suivi [44].…”