Granulomatous Mastitis: A Spectrum of Disease

Vinayagam, Ragu; Cox, Julie; Webb, L.A.

doi:10.1159/000229541

Cited by 32 publications

(28 citation statements)

References 11 publications

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“…The diagnosis of IGM is based on the exclusion of other granulomatous diseases, such as tuberculosis, sarcoidosis, Wegener's granulomatosis and connective tissue disorders. In our patient, the negative laboratory results and lack of other clinical features of that spectrum of diseases supported the differential diagnosis (3,4,6).…”

Section: Discussionsupporting

confidence: 64%

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Idiopathic Granulomatous Mastitis Associated with Erythema Nodosum

Kalaycı¹,

Koruyucu²,

Apaydin³

et al. 2016

Balkan Med J

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Background: Idiopathic granulomatous mastitis (IGM) is an uncommon benign chronic inflammatory breast disease, and erythema nodosum (EN) is an extremely rare systemic manifestation of IGM. Here, we report a rare case of IGM accompanied by EN. Case Report: A 32-year-old patient was admitted to our clinic with a history of a tender mass in the right breast. On physical examination, the right breast contained a hard, tender mass in the lower half with indrawing of the nipple. She had florid EN affecting both legs. She was evaluated with mammography, ultrasound, power Doppler ultrasound, non-enhancing magnetic resonance imaging (MRI), dynamic contrastenhanced MRI, fine needle aspiration biopsy (FNAB) and excisional biopsy. Time-intensity curves showed a type II pattern on dynamic contrast-enhanced MRI, which has an intermediate probability for malignancy. The FNAB reported a benign cytology suggestive of a granulomatous inflammation, which was also supported by the histopathological findings. A partial mastectomy was performed following medical treatment. There was no recurrence at 1-year follow-up. Conclusion: IGM should be considered in the differential diagnosis of EN. Although histopathological examination remains the only method for the definite diagnosis of IGM, MRI can be helpful in the diagnosis or differentiation of benign lesions from malignant ones.

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Section: Discussionsupporting

confidence: 64%

“…It is clinically characterized by hard breast lumps with local inflammation, galactorrhea, tumorous indurations and skin ulcerations. Histologically, it is characterized by the presence of non-caseous granulomatous lobulitis (3,4). Erythema nodosum (EN) is an extremely rare systemic manifestation of IGM.…”

mentioning

confidence: 99%

Idiopathic Granulomatous Mastitis Associated with Erythema Nodosum

Kalaycı¹,

Koruyucu²,

Apaydin³

et al. 2016

Balkan Med J

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“…Many causative agents have been reported to be linked with the condition like -local irritant, oral contraceptive pill, viruses, mycotic and parasitic infections, hyperprolactinemia, diabetes mellitus, smoking, alfa 1 antitrypsin deficiency, autoimmunity have been proposed to explain the etiology of IGM but never proven. [2][3][4][5][6][7] IGM presents most commonly with a unilateral painful, firm, tender, ill defined mass in the breast 7,8 . The lesions may be located in any quadrant of the breast 7 .…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Granulomatous Mastitis- Challenges of Diagnosis and Treatment

et al. 2017

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“…La mastitis granulomatosa lobular o idiopática (MGI), una enfermedad benigna de etiología no definida, afecta también a mujeres jóvenes en edad reproductiva, presenta compromiso unilateral predominante y se manifiesta como un nódulo o absceso con retracción del pezón, ulceración, fistulización y síntomas sistémicos infrecuentes. No obstante, este diagnóstico amerita además de características anatomo-patológicas típicas, el descarte de otras causas de mastitis granulomatosa (20)(21)(22)(23)(24)(25).…”

Section: Discussionunclassified

Características clínicas y anatomo-patológicas de las pacientes que ingresaron al Programa de Control de Tuberculosis con diagnóstico de tuberculosis de mama

Tafur¹,

Cáceres²,

Accinelli³

2014

Rev Med Hered

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Objetivo: Describir las características clínicas y anatomo-patológicas de pacientes que ingresaron con diagnóstico de TB de mama al Programa de control de Tuberculosis (PCT) de un hospital general. Material y métodos: Se incluyeron los casos registrados en el PCT como TB de mama en cuyo informe anatomo-patológico figuraba inflamación crónica granulomatosa. Se revisaron las historias clínicas y revaluaron las biopsias de mama. Resultados: Se incluyeron 69 mujeres con edad promedio 35,79 ± 7,94 años. Las manifestaciones más frecuentes fueron presencia de nódulo (89,86%), dolor (89,86%) y signos inflamatorios (40,58%). La revaluación de la biopsia mostró granulomas de tipo supurado, con células gigantes multinucleadas tipo Langhans y cuerpo extraño, sin necrosis caseosa, localizados a nivel de la unidad ducto lobular (UDL) y extra-UDL en 85,51 % de los casos. Solo en 3 casos se observó bacilos ácido alcohol resistente en la secreción o tejido de mama. Todos los casos recibieron tratamiento antituberculoso. Treinta y ocho casos tuvieron seguimiento, de ellos 73,68% presentó persistencia o recurrencia al menos un mes después del inicio de tratamiento antituberculoso. Conclusiones: Todos los casos del estudio fueron mujeres, la mayoría presentaron nódulo, dolor o signos de inflamación en mama, sin síntomas o signos sistémicos y con presencia de granulomas supurados, sin necrosis caseosa. A pesar de recibir tratamiento antituberculoso en todos los casos, cerca del 75% con seguimiento de al menos un mes presentaron persistencia o recurrencia clínica.

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Granulomatous Mastitis: A Spectrum of Disease

Cited by 32 publications

References 11 publications

Idiopathic Granulomatous Mastitis Associated with Erythema Nodosum

Idiopathic Granulomatous Mastitis Associated with Erythema Nodosum

Idiopathic Granulomatous Mastitis- Challenges of Diagnosis and Treatment

Características clínicas y anatomo-patológicas de las pacientes que ingresaron al Programa de Control de Tuberculosis con diagnóstico de tuberculosis de mama

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