Wegener's granulomatosis in North India

Bambery, P.; Katariya, S.; Sakhuja, Vinay; Kaur, Upinder; Behera, Digambar; Malik, Shahid; Deodhar, Sharad D.

doi:10.3109/02841858809171203

Cited by 3 publications

(16 citation statements)

References 23 publications

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“…The infrequent recourse to open lung biopsy and autopsy also contribute significantly to the paucity of information. 30 ' 31 The clinical, radiologic, and morphologic features of WG (Table 2) and its complications in India are very similar to patterns observed in several large series of patients. 18,23,[33][34][35][36][37][38][39][40][41][42] There have, however, been some important differences.…”

Section: Group a Wegener's Granulomatosissupporting

confidence: 64%

“…Since then, a few isolated cases were described until we published our observations based on 11 patients. [30][31][32] Presently, at our institute, a clinical diagnosis of WG is made and confirmed in about two or three new patients each year. Increased awareness of this condition has led to more patients being recognized at the All India Institute of Medical Sciences, New Delhi (AN Malaviya: Personal communication) also.…”

Section: Group a Wegener's Granulomatosismentioning

confidence: 99%

“…We are also certain that several patients would have died due to WG but recorded as having resistant tuberculosis. 30 Treatment with cyclophosphamide combined with corticosteroids has been very gratifying in those patients who could receive medication for a few weeks. 30 Many unfortunate patients received a single or two or three doses preterminally.…”

Section: Group a Wegener's Granulomatosismentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary Vasculitis: An Indian Perspective

Bambery¹,

Bhushnurmath²,

Jindal³

et al. 1991

Semin Respir Crit Care Med

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Section: Group a Wegener's Granulomatosissupporting

confidence: 64%

Section: Group a Wegener's Granulomatosismentioning

confidence: 99%

Section: Group a Wegener's Granulomatosismentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary Vasculitis: An Indian Perspective

Bambery¹,

Bhushnurmath²,

Jindal³

et al. 1991

Semin Respir Crit Care Med

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“…Most nodules become excavated throughout the course of untreated disease. 6 Also revealed by pulmonary imaging are infiltrates consisting of alveolar opacities. The appearance of these infiltrates varies widely, and they are classified into three loosely defined categories.…”

Section: Discussionmentioning

confidence: 99%

“…The appearance of these infiltrates varies widely, and they are classified into three loosely defined categories. [5][6][7][8] The first category is characterized by diffuse, bilateral infiltrates oflow density. Patients with this type of infiltrate commonly present with alveolar hemorrhage syndrome, a fulminant, acute disorder characterized by dyspnea, hemoptysis, and severe anemia.…”

Section: Discussionmentioning

confidence: 99%

Wegener's granulomatosis

Wellish

Tenner²,

Cowan³

1993

Postgraduate Medicine

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Clinical profile and management of granulomatosis with polyangiitis–associated scleritis from a tertiary care hospital in South India

Mohanan-Earatt

Biswas

2023

Indian J Ophthalmol

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Purpose: To describe the clinical features and management of patients with scleritis associated with granulomatosis with polyangiitis (GPA) at a tertiary eye care center in South India. Methods: The clinical profile and management of patients presenting to a tertiary eye care center in South India with scleritis secondary to GPA from 2003 to 2021 were analyzed retrospectively. Scleritis was classified into anterior diffuse, nodular, and necrotizing scleritis with inflammation according to Watson and Hayreh’s classification. Demographic characteristics, clinical features, anti-neutrophil cytoplasmic antibody (ANCA) positivity, treatment response, ocular complications, and status at the last follow-up were analyzed. Statistical analysis of data was performed using Microsoft Excel 2019. Results: Nineteen eyes of 17 patients (15 cytoplasmic staining ANCA [c-ANCA], two p-ANCA positive) were included. Fifteen eyes had necrotizing scleritis, two had diffuse anterior scleritis, and two had nodular scleritis. Remission was induced using a combination of steroids and cyclophosphamide or rituximab. Maintenance therapy was instituted using tapering steroids and immunosuppressants like cyclophosphamide, mycophenolate mofetil, methotrexate, or rituximab. Three eyes required a scleral patch graft. Fourteen patients had good anatomical and visual outcomes, and three were lost to follow-up. Conclusion: GPA is a rare disease, while it is the most common ANCA-associated vasculitis with scleritis. As scleritis may be the presenting sign of the disease, ophthalmologists must be aware of the various features suggestive of GPA. GPA-associated scleritis can have a good prognosis when diagnosed promptly and managed aggressively in the acute stage, and remission is maintained with adequate systemic immunosuppression.

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Wegener's granulomatosis in North India

Cited by 3 publications

References 23 publications

Pulmonary Vasculitis: An Indian Perspective

Pulmonary Vasculitis: An Indian Perspective

Wegener's granulomatosis

Clinical profile and management of granulomatosis with polyangiitis–associated scleritis from a tertiary care hospital in South India

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