Pulmonary Vasculitis: An Indian Perspective

Bambery, P; Bhushnurmath, Bharati; Jindal, Surinder K.; Datta, B N

doi:10.1055/s-2007-1006232

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Vasculitis is a well-established feature of tuberculosis of the central nervous system (CNS),[ 22 23 ] lungs,[ 24 ] and kidneys,[ 25 ] but scarcely described in intestinal tuberculosis. Few studies have evaluated the role of mesenteric vasculitis in the natural history of intestinal tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Abdominal Tuberculosis: A Histopathological Study with Special Reference to Intestinal Perforation and Mesenteric Vasculopathy

2009

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Background:Along with the increased incidence of pulmonary tuberculosis in parallel with the increase in population in various parts of the world, in recent years, the incidence of abdominal tuberculosis has also increased. The pathogenetic events in intestinal tuberculosis, which culminate in ulcer formation, perforation, and stricture, still have to be identified.Aim:To correlate the gross and microscopic features in intestinal tuberculosis, in particular tuberculous perforation with changes in mesenteric vasculature.Patients and Methods:A one-year prospective study of excised/resected tissues from patients with abdominal tuberculosis requiring surgical intervention was conducted. Tissues from fifty-six patients were included in the study—of which 36 were resected intestinal segments and 20 were intestinal and lymph node biopsies. Hematoxylin and Eosin and Ziehl-Neelsen stains were used for histopathological examination.Results:Tuberculous enteritis was found to be present in 49 of the 56 patients (87.5%) (ileum being the site most commonly affected), while nodal involvement was seen in 39 (69.6%) patients. Perforations were present in 39 out of 49 (79.6%) intestinal tissues; most being solitary and ileum was the commonest site. Typical epithelioid cell granulomas were seen in the intestine and lymph nodes, with caseation being more prevalent in the latter. The mesenteric vasculature was frequently involved by granulomatous inflammation, with intravascular organizing thrombus being present in 30% of the resected specimens with perforation. Acid fast bacilli were demonstrated in the tissue sections of 37.5% of the patients. AFB positivity was higher in caseating granulomas.Conclusion:Involvement of mesenteric vasculature by granulomatous inflammation was commonly associated with the ulcerative type with perforation, suggesting that ischemia caused by vascular thrombosis is responsible for tissue breakdown. This implies that vasculitis plays an important role in the natural history of abdominal tuberculosis.

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Section: Introductionmentioning

confidence: 99%

Abdominal Tuberculosis: A Histopathological Study with Special Reference to Intestinal Perforation and Mesenteric Vasculopathy

2009

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“…15 Also, vasculitis is a well-established feature of CNS, lung and renal TB but barely described in intestinal tuberculosis. [16][17][18][19] Few more studies have assessed the role of mesenteric vasculitis in the natural history of intestinal tuberculosis. 20,21 Prospective study by Dasgupta A et al of 56 abdominal tuberculosis patients, who required surgery for obstruction or perforation, showed that mesenteric vasculature (medium and small vessels) is frequently involved by granulomatous inflammation, with intravascular organizing thrombus in upto 30% specimens with perforation.…”

Section: -14mentioning

confidence: 99%

Acute mesenteric ischemia with tuberculous mesenteric lymphadenitis in a young female

2017

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We present the case of an 18 year old female with tuberculous mesenteric lymphadenopathy who came to hospital with peritonitis and acute mesenteric ischemia. An emergency exploratory laparotomy with resection of gangrenous small bowel and right colon with end-to-end anastomosis was performed. Subsequent evaluation for etiology of bowel gangrene was essentially normal. By exclusion, the most likely cause of acute mesenteric ischemia in this patient was of unknown etiology which is indeed rare. However, tuberculosis as a cause of mesenteric vasculitis and bowel gangrene needs to be explored.

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Pulmonary Vasculitis: An Indian Perspective

Cited by 2 publications

References 28 publications

Abdominal Tuberculosis: A Histopathological Study with Special Reference to Intestinal Perforation and Mesenteric Vasculopathy

Abdominal Tuberculosis: A Histopathological Study with Special Reference to Intestinal Perforation and Mesenteric Vasculopathy

Acute mesenteric ischemia with tuberculous mesenteric lymphadenitis in a young female

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