Weak electromagnetic fields (50Hz) elicit a stress response in human cells

Tokalov, Sergey V.; Gutzeit, Herwig O.

doi:10.1016/s0013-9351(03)00088-4

Cited by 90 publications

(81 citation statements)

References 32 publications

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“…While there were several minor procedural differences, such as normalizing the expression of Hsp70 to a housekeeper gene (beta-2-microglobulin), none of them appeared significant. Balcer-Kubiczek et al Tokalov and Gutzeit [2004] found a somewhat similar dose-response at 50 Hz, with hsp70 mRNA transcripts expressed for 30 min at 10 mT, a maximal response around 40-80 mT, and no response at higher field intensities (140 mT). The magnetic field exposure was also able to enhance the HSP response following 43 8C heat stress.…”

Section: Mechanisms: Heat Shock Proteinsmentioning

confidence: 78%

“…Miyakawa et al [2001] found that the temperature required for a given expression of a reporter gene (lacZ) under HSP16 promoter control in transgenic nematode worms was reduced after exposure to a 60 Hz magnetic field at up to 0.5 T. Leszczynski et al [2002] saw an increase in protein phosphorylation and Hsp27 expression after exposure to a 900 MHz GSM signal. Other reports, discussed previously, have found magnetic field influences on Hsp16 activity in nematodes [Junkersdorf et al, 2000], as well as Hsp27 in cell cultures [Pipkin et al, 1999;Tokalov and Gutzeit, 2004]. Controversy exists for studies of HSP27 as well, and no effect was seen in several papers [Guisasola et al, 2002;Shi et al, 2003;Coulton et al, 2004;Lim et al, 2005].…”

Section: Mechanisms: Heat Shock Proteinsmentioning

confidence: 93%

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The influence of extremely low frequency magnetic fields on cytoprotection and repair

Robertson

Thomas

Bureau

et al. 2006

Bioelectromagnetics

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Ischemia-reperfusion injuries, such as those suffered from various types of cardiovascular disease, are major causes of death and disability. For relatively short periods of ischemia, much of the damage is potentially reversible and in fact, does not occur until the influx of oxygen during the reperfusion stage. Because of this, there is a window of opportunity to protect the ischemic tissue. Here, we review several mechanisms of protection, such as heat shock proteins, opioids, collateral blood flow, and nitric oxide induction, and the evidence indicating that magnetic fields may be used as a means of providing protection via each of these mechanisms. While there are few studies demonstrating direct protection with magnetic field therapies, there are a number of published reports indicating that electromagnetic fields may be able to influence some of the biochemical systems with protective applications.

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Section: Mechanisms: Heat Shock Proteinsmentioning

confidence: 78%

Section: Mechanisms: Heat Shock Proteinsmentioning

confidence: 93%

The influence of extremely low frequency magnetic fields on cytoprotection and repair

Robertson

Thomas

Bureau

et al. 2006

Bioelectromagnetics

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“…n ¼ 3 for IM signal, n ¼ 1for 50 Hz signal. Reale et al, 2006] or HL-60 myeloid leukemia cells [Tokalov and Gutzeit, 2004]. Changes in the gene expression of pro-inflammatory genes were also found in skin cells [Vianale et al, 2008].…”

Section: Discussionmentioning

confidence: 96%

Low‐frequency electromagnetic fields do not alter responses of inflammatory genes and proteins in human monocytes and immune cell lines

Bouwens

Kleijn

Ferwerda

et al. 2011

Bioelectromagnetics

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The effects of low frequency electromagnetic fields (LF EMF) on human health are the subject of on-going research and serious public concern. These fields potentially elicit small effects that have been proposed to have consequences, either positive or negative, for biological systems. To reveal potentially weak but biologically relevant effects, we chose to extensively examine exposure of immune cells to two different signals, namely a complex multiple waveform field, and a 50 Hz sine wave. These immune cells are highly responsive and, in vivo, modulation of cytokine expression responses can result in systemic health effects. Using time course experiments, we determined kinetics of cytokine and other inflammation-related genes in a human monocytic leukemia cell line, THP-1, and primary monocytes and macrophages. Moreover, cytokine protein levels in THP-1 monocytes were determined. Exposure to either of the two signals did not result in a significant effect on gene and protein expression in the studied immune cells. Also, additional experiments using non-immune cells showed no effects of the signals on cytokine gene expression. We therefore conclude that these LF EMF exposure conditions are not expected to significantly modulate innate immune signaling. Bioelectromagnetics ß 2011 Wiley-Liss, Inc.

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“…A large part of them use exposures way above the levels that, in general, are present in home environments 16,21 . Such is the case of the stu� dies of Iorio et al 22 , who found an increase in the mobility of spermatozoids exposed to fields starting from the minimum intensity of 2.5 mT, and Tokalov and Gutzeit 23 , who found differences in the expression of stress proteins upon cell stimulation by MF from 10 to 140 mT.…”

Section: Biological Mechanismsmentioning

confidence: 93%

“…�on�identification of a target organ (or target mechanism) for MF poses a challenge for experimental studies about their health effects 23 . Lack of independent replication is also frequent in such studies, which makes it difficult to establish a causal association between MF exposure and health effects 16 .…”

Section: Biological Mechanismsmentioning

confidence: 99%

Campos magnéticos de frequência extremamente baixa e efeitos na saúde: revisão da literatura

Marcílio

Habermann

2009

Rev. bras. epidemiol.

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Este estudo foi financiado pela ANEEL -Agência Nacional de Energia Elétrica. AbstractSince an epidemiologic report, in 1979, showed an association between childhood leukemia and exposure to magnetic fields, concerns over the subject have grown, and several other studies have been published. The main goal of this literature review is to present the methods of exposure assess� ment and the main difficulties in measuring exposure, and also to report the results of epidemiological studies published along the past ten years. The lack of biophysical mechanisms explaining the interaction between magnetic fields and health, and the difficulties regarding exposure assessment have been the main obstacles of research in this area. Leukemia and brain tumors are the most evaluated outcomes. Childhood leukemia has been the most consistently outcome associated with magnetic field exposure. Recent studies have also shown an association between magnetic fields and amyotrophic lateral sclerosis.

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Weak electromagnetic fields (50Hz) elicit a stress response in human cells

Cited by 90 publications

References 32 publications

The influence of extremely low frequency magnetic fields on cytoprotection and repair

The influence of extremely low frequency magnetic fields on cytoprotection and repair

Low‐frequency electromagnetic fields do not alter responses of inflammatory genes and proteins in human monocytes and immune cell lines

Campos magnéticos de frequência extremamente baixa e efeitos na saúde: revisão da literatura

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