The influence of extremely low frequency magnetic fields on cytoprotection and repair

Abstract

Ischemia-reperfusion injuries, such as those suffered from various types of cardiovascular disease, are major causes of death and disability. For relatively short periods of ischemia, much of the damage is potentially reversible and in fact, does not occur until the influx of oxygen during the reperfusion stage. Because of this, there is a window of opportunity to protect the ischemic tissue. Here, we review several mechanisms of protection, such as heat shock proteins, opioids, collateral blood flow, and nitric oxide induction, and the evidence indicating that magnetic fields may be used as a means of providing protection via each of these mechanisms. While there are few studies demonstrating direct protection with magnetic field therapies, there are a number of published reports indicating that electromagnetic fields may be able to influence some of the biochemical systems with protective applications.

Effect of low frequency modulated microwave exposure on human EEG: Individual sensitivity

“…This phenomenon is similar to the effect caused by Brownian motion, initiated by temperature, and results in the same effects-the mobility of the ions and fluctuations in membrane motions are increasing. Such a quasithermal field-tissue mechanism is supported by the findings that low-level electromagnetic radiation exposure induces changes in heat shock proteins [Leszczynski et al, 2002;Robertson et al, 2007]. Therefore, the quasi-thermal effect produced by a microwave exposure can be altered by low-frequency modulation neuronal-cortical activity.…”

Anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liver

“…Even though celecoxib is a synthetic molecule and ELF-EMF is an interaction energy, both have anti-carcinogenic effects; however, when celecoxib is administered at high doses increases the risk of cardiovascular events [29]. Given the efficacy shown by ELF-EMF exposure, our results motivate the evaluation of the synergic effect of ELF-EMF in combination with low doses of celecoxib, which could increase their efficacy and minimize the cardiovascular damage [30,31]; this combination of treatments could have an analogous result to the combination of low doses of X-ray or gamma radiation plus ELF-EMF exposure [8,25]. …”

Emerging Synergisms Between Drugs and Physiologically-Patterned Weak Magnetic Fields: Implications for Neuropharmacology and the Human Population in the Twenty-First Century

“…Five of the most likely electric, magnetic or synergistic mechanisms to examine the nature of magnetic field transduction in biological systems have been proposed [ 29 ] and each has its own support within the literature. Other notable models exist [ 32 ] which explain the replicable effects of MF on cellular physiology [ 4 , 125 , 128 , 150 , 178 ], particularly the dynamic interactions with blood flow and microvasculature [ 92 ].…”