Abstract-The promise of smart cities offers the potential to change the way we live, and refers to the integration of IoT systems for people-centred applications, together with the collection and processing of data, and associated decision making. Central to the realization of this are wearable and autonomous computing systems. There are considerable challenges that exist in this space that require research across different areas of electronics and computer science; it is this multidisciplinary consideration that is novel to this paper. We consider these challenges from different perspectives, involving research in devices, infrastructure and software. Specifically, the challenges considered are related to IoT systems and networking, autonomous computing, wearable sensors and electronics, and the coordination of collectives comprising human and software agents.